DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and TMA108

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	1000	Identity:	205/1000 - (20%)
Similarity:	369/1000 - (36%)	Gaps:	241/1000 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LVPLSYRVDIVTRINQPYQPFGGTVVIDLRSE------------------RSTKRIVLNAHDLAI 76
            :||..|.:.:.....|....|.|:.:|.|:..                  .|...|||:||....
Yeast    12 VVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHATIG 76

  Fly    77 GKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSN 141
            ..:..:.:|...|..:.:.:.:..|:||.     ..||.::|.|..::.......:...|.:.:|
Yeast    77 STKFDLKISQDTGKHLSIFNSESPIQLSN-----DCPLILSVQYVGKIRDIKTHHDKTFGIFKTN 136

  Fly   142 YVDHNT-TLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHAS 205
            ::|..| |....:.||..:|..|...|||.|:|..::.|::|:|....|:|:||.||:......|
Yeast   137 FMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDS 201

  Fly   206 LKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSE---RSD--CPISTWARPDALSQTEFANMV 265
            .:.:: .:|.::..|.|.:..|.|...:   |..:|   ..|  .|:|.:| |..::...|....
Yeast   202 SQKHL-VKFAKTPLMTTSVFGFSIGDLE---FLKTEIKLEGDRTIPVSIYA-PWDIANAAFTLDT 261

  Fly   266 VAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGL------------PAFAEESLLYDSQR 318
            |...|...|..|...|...|:|.|.||..:..:.||:|:            .|.|.|::...:|:
Yeast   262 VQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQ 326

  Fly   319 SSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDY-----QE 378
            ..:.:           :|:||.||.:|...|..:|....||.:|:   .|.|....|.     .|
Yeast   327 LIVHE-----------LVHQWMGNYISFDSWESLWFNESFATWLA---CHILEQNGDLSHYWTSE 377

  Fly   379 RHALQLYLSVLDYDA--------------HVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEML 429
            .:.||.....:..||              :...|..|:.:.|..    ||.     |..::...|
Yeast   378 PYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPE----AYT-----KGIIMLRSL 433

  Fly   430 HRVMGE---EAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPG 491
            ....||   :..|.::......:..|:....|.|:.:       |:..|..|||..:..|...||
Yeast   434 QLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHI-------GKFLKSQNITNFVSSWTRTPG 491

  Fly   492 YPLVTV-TRNYDHRTAI-VSQQRFF--ITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWL 552
            .|:|.| ....|.:|.. ::|.||.  ::.:.:::....| :.|||                 :.
Yeast   492 LPVVKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVP-YQVPL-----------------FG 538

  Fly   553 TCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAP--FRVNYDLRN-WQLLNKTLADPNKFRLI 614
            ..|..|..:| |.:|.::  ....|:.:..:.|.|.  :||:|:... :.|:|..:.:    ..:
Yeast   539 VLPDGKMDTK-NVLLTDR--TLKFDYPILVINHLAQGYYRVSYESEECYALINDKITE----ETL 596

  Fly   615 HRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIF 679
            ..::..::..||..  :.||..:..::.:.|.                |:.:|::|  :|:..|.
Yeast   597 SEIDLRKIFLDLSQ--FIGDEGFQNSIHLHGL----------------FKILNHIA--SPSTKIA 641

  Fly   680 KTYMRLLLE--RQFKRVISSDLTSSS-GNMTHRPVIIRLACEYELPACVSLARREFMKGTPEKGG 741
            ..|...|.:  ...:.:..:.||||. .:...:.::|.|..:.:.|      ..||.|.|
Yeast   642 SKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWP------HGEFDKST----- 695

  Fly   742 WMTIRERETVVCTAVKFGTEGDRDMVE--SMY-------KRSNFAAE-KESLLTALA--CSRNVF 794
                ...|..|.:.|.|..:......|  .:|       .||:...| ..|:|..::  |: |:.
Yeast   696 ----NPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCA-NIK 755

  Fly   795 ALQRV--LIWTFESSGVRK-------QNARRTFKAVVS---NSMGYRLAKKYVSVNMQNIRNYCS 847
            ..:::  |:.....:|:..       ||:..|...:.:   .|:|:.|.               |
Yeast   756 QWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLD---------------S 805

  Fly   848 NSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHWQRTKFRPM 912
            :...|.:|.:|..||.......|..|:..||   :.:|.:|                     :|.
Yeast   806 DIVKKTLNFITSNIESEGMELALFGFNYNFK---KRLNKNE---------------------KPQ 846

  Fly   913 LQAIRDII---------LWRSRAKR 928
            .|.:|:.|         .|..:|.|
Yeast   847 DQVVRETIWEWYMGNFDQWARKATR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	101/445 (23%)
		M1_APN_2	33..493	CDD:189008	115/517 (22%)
		ERAP1_C	579..897	CDD:288671	63/347 (18%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	204/999 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910