DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and APE2

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	887	Identity:	211/887 - (23%)
Similarity:	365/887 - (41%)	Gaps:	147/887 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLR-SERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            ||..:|||.|  |:....:.....|.|:|.|:|: :..:...:.||..|..|   .:..:.|...
Yeast   102 LPDNVVPLHY--DLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDI---HSAKIGDVTS 161

  Fly    90 NSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLA 154
            :.: :|..:..:.............|.|.  .:.:.||.:|.::..|||.:.|.|..|..|:::|
Yeast   162 SEI-ISEEEQQVTTFAFPKGTMSSFKGNA--FLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMA 223

  Fly   155 ATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYV-----WTQF 214
            .||.||..||.||||||:|..:..|.|.|........||||.|:        .:||     .|.|
Yeast   224 TTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVK--------NEYVKDGKKVTLF 280

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNS 279
            ..:..|.||||||::::..   :..|:....|:..:|.|......:||..:.|..|:|:|..|..
Yeast   281 NTTPKMSTYLVAFIVAELK---YVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGI 342

  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344
            .|...|:|.||:.:|:..:.|||||..:....||.|...|::|..|.||..|...:.:|||||||
Yeast   343 QYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLV 407

  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESH 409
            ::.||..:||...||.::|.:..:..:|||...|::........|..|:..::..:...|.....
Yeast   408 TMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADE 472

  Fly   410 IWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLG 474
            |...::.|...|.|.|..|:.:.:|||.::..:.:||..:....|.:.|.||.|   .|.:|:
Yeast   473 INQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDAL---ADASGK-- 532

  Fly   475 KGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPS 539
               ::..:|..|..:.|:|:::|:.:.:.:... .|.|:..|...:
Yeast   533 ---DVRSVMNIWTKKVGFPVISVSEDGNGKITF-RQNRYLSTADVK------------------- 574

  Fly   540 CQHSEIISFSRWLTCPTSKPSSKSNTVLLEK---LEAEPTDWILFNVQHTAPFRVNYDLRNWQLL 601
             ...:...:..:|...| |....|:.||.|:   :|.|...:...|.:.:..:..:|....|..|
Yeast   575 -PDEDKTIYPVFLALKT-KNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKL 637

  Fly   602 NKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERI 666
            .:. ||     |:...:|..||.|:.:|:.||.......|.::....:|..||||      .:.|
Yeast   638 GQQ-AD-----LLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVW------DQII 690

  Fly   667 NNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTHRPVIIRLACEYELPACVSLARRE 731
            |:::.....:|......:..|:...|::||        .|||     .|..|::.....|..|
Yeast   691 NSISSMKSTWLFEPKETQDALDNFTKQLIS--------GMTH-----HLGWEFKSSDSFSTQR-- 740

  Fly   732 FMKGTPEKGGWMTIRERETVVCTAVKFGTE---GDRDMVESMYKRSNFAA--------------- 778
             :|.| ..|.....|:.: |...|:|..|:   |:::.:.::.|...|..
Yeast   741 -LKVT-MFGAACAARDAD-VEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYK 802

  Fly   779 ---------EKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKY 834
                     ||.:.|.:|...:....|:|.|.:.|:.:.:.:.
Yeast   803 IYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQD---------------------- 845

  Fly   835 VSVNMQNIR----------NYCSNSTDKVVNLMTPLIECLST 866
            :.:.||.:|          |:...:.|::|..:.|.:..|.:
Yeast   846 IYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	117/400 (29%)
		M1_APN_2	33..493	CDD:189008	132/465 (28%)
		ERAP1_C	579..897	CDD:288671	61/325 (19%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	211/887 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910