DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and APM1

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	945	Identity:	250/945 - (26%)
Similarity:	390/945 - (41%)	Gaps:	159/945 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQP------FGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVT 83
            ||||:.||..|.:    |:|    |      |.|||.|||.....|:.|||||.||::
plant     9 RLPKFAVPKRYDL----RLN----PDLIACTFTGTVAIDLDIVADTRFIVLNAADLSV------- 58

  Fly    84 LSDKNGNSVPVSSIQM----------DIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFY 138
             :|.:.:..|.||.:.          :.::..|......|..|.|   :::.|..||.:...|||
plant    59 -NDASVSFTPPSSSKALAAPKVVLFEEDEILVLEFGEILPHGVGV---LKLGFNGVLNDKMKGFY 119

  Fly   139 SSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRH 203
            .|.| :||..... :|.|||||..||..|||:|:|..:..|||.|..|....||||||:.....:
plant   120 RSTY-EHNGEKKN-MAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIMEEKVN 182

  Fly   204 ASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSD-CPISTWARPDALSQTEFANMVVA 267
            .:||   ...:.||..|.|||||.::..||   :.....|| ..:..:.:.....|.:||..|.|
plant   183 GNLK---IVSYQESPIMSTYLVAIVVGLFD---YVEDHTSDGIKVRVYCQVGKADQGKFALHVGA 241

  Fly   268 PLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVA 332
            ..|..:::.|...|...|:|::|:|||...:.||:||..:.|.:||||.|.|:..::|.||..||
plant   242 KTLDLFKEYFAVPYPLPKMDMIAIPDFAAGAMENYGLVTYRETALLYDEQHSAASNKQRVATVVA 306

  Fly   333 MMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEW----DYQERHALQLYLSVLDYDA 393
            ..:.:|||||||::.||..:||...||.::|.....||.|||    .:.:.....|.|..|:...
plant   307 HELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGLRLDGLEESH 371

  Fly   394 HVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSD 458
            .:..::..|:..||     .::.|..||.|.:..||...:|.|.:..:|..|:..:|...|.:.|
plant   372 PIEVEVNHAAEIDE-----IFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTED 431

  Fly   459 FWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRW 523
            .|..|:        .|.|..:.::|..|..|.|||:|: .:..|.:..: .|.||..
plant   432 LWAALE--------AGSGEPVNKLMSSWTKQKGYPVVS-AKIKDGKLEL-EQSRFLS-------- 478

  Fly   524 ARNP---CWWVPLSYTCPSCQ---------HSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPT 576
            :.:|   .|.||::..|.|.:         .|........|.|..:..|.|.|..         .
plant   479 SGSPGEGQWIVPVTLCCGSYEKRKNFLLESKSGAYDLKELLGCSIADGSDKINGT---------C 534

  Fly   577 DWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMAL 641
            .||..||.....:||.||    ..|...|.:..:.:.:..::|..::||.|:|..:........|
plant   535 SWIKINVDQAGFYRVKYD----DSLAAGLRNATESQSLTSIDRYGILDDSFALTMARQQSLASLL 595

  Fly   642 GIL-GYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGN 705
            .:. .|.:..|..|:.....||::.:...|.:|..           |....|.........::|.
plant   596 TLCSAYKKELDYTVLSNLIAISYKVVKIGADANQE-----------LMSGIKHFFIGVFQFAAGK 649

  Fly   706 MTHRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE---------------------RE 749
            :...|    ...|..|.|   :.|.|.:......|...|::|                     |.
plant   650 LGWDP----KQGESHLDA---MLRGEVLTALAVFGHDETLKEAVRRFDAFLADRNTPLLPPDIRR 707

  Fly   750 TVVCTAVKFGTEGDRDMVESM---YKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRK 811
            ......::...:.|:...||:   |:.::.:.||..:|.:||...:...:|.||.:.. |..||.
plant   708 AAYVAVMQRANKSDKSGYESLLRVYRETDLSQEKTRILGSLASCPDPTIVQDVLNFVL-SDEVRN 771

  Fly   812 QNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKF 876
            |:|......|  :..|..:|.|::....:.|.|...:..     |:|..|..:.:|     |:.|
plant   772 QDALYGLSGV--SWEGREVAWKWLQEKWEYIGNTWGSGF-----LITRFISAVVSP-----FASF 824

  Fly   877 --FKEI-----LRDMNGSERLIKILLERGNDNIHW 904
              .||:     .|......|.:|..:||.:.|.:|
plant   825 EKAKEVEEFFATRSKPSMARTLKQSIERVHINANW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	137/416 (33%)
		M1_APN_2	33..493	CDD:189008	151/480 (31%)
		ERAP1_C	579..897	CDD:288671	69/349 (20%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	149/474 (31%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	72/353 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920