DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2111 and Anpep

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_112274.1	Gene:	Anpep / 81641	RGDID:	2991	Length:	965	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	262/950 - (27%)
Similarity:	425/950 - (44%)	Gaps:	116/950 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDI---VTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAI---GKRRAVT 83
            ||||.|:|.||:|.:   :|...|....|.|:..:......:|..|::::..|..   |..| |.
  Rat    75 RLPKTLIPDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKGNHR-VA 138

  Fly    84 LSDKNGNSVP-VSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNT 147
            |........| :.:.::..:...|.|.|:..|.....|.|...|...|.:|..|||.|.|::...
  Rat   139 LRALGDTPAPNIDTTELVERTEYLVVHLQGSLVKGHQYEMDSEFQGELADDLAGFYRSEYMEGGN 203

  Fly   148 TLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNM--PVQRTIRHASLKDYV 210
              .:.:|.||.:...||::|||||:|..:..|.|.|.||....|||||  ...||::    :|..
  Rat   204 --KKVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTALSNMLPKDSRTLQ----EDPS 262

  Fly   211 W--TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQ--TEFANMVVAPLLS 271
            |  |:|..:..|.|||:|:::|:|......|..|  ..|..||||.|:.:  .::|..|..|:|:
  Rat   263 WNVTEFHPTPKMSTYLLAYIVSEFKYVEAVSPNR--VQIRIWARPSAIDEGHGDYALQVTGPILN 325

  Fly   272 FYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVV 336
            |:...:|:.|..:|.|.:|||||...:.|||||..:.|.:|::|.|.|||.:::.|...:|..:.
  Rat   326 FFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSSSISNKERVVTVIAHELA 390

  Fly   337 NQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVT 401
            :|||||||:|.||:::||...||.|:...|.....|.|:.::...|.....|:..||..::..::
  Rat   391 HQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLNDVYRVMAVDALASSHPLS 455

  Fly   402 A---SVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLL 463
            :   .|...:.|...::.|...|.|.:..||...:.|:.:...|..||..:........|.|:.|
  Rat   456 SPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYLHTFQYSNTIYLDLWEHL 520

  Fly   464 QLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWAR--- 525
            |..||....:....:::.||..|:.|.|:|::||..:    |..:.|:.|.:.|  .::..|
  Rat   521 QQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVNTS----TGEIYQEHFLLDP--TSKPTRPSD 579

  Fly   526 -NPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPF 589
             |..|.||:.|.....:.      ..||  .|.|..|       .:.:....:|:|.|:..|..:
  Rat   580 FNYLWIVPIPYLKNGKED------HYWL--ETEKNQS-------AEFQTSSNEWLLLNINVTGYY 629

  Fly   590 RVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFV 654
            :||||..||:.:...|  .....:|..:||||::.|.|:||.:|.:...:.|....:|..|.|::
  Rat   630 QVNYDENNWRKIQNQL--QTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYM 692

  Fly   655 VWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQ-----FKRVISSDLTS-------SSGNMT 707
            .|.|           |.|:.|      |.:|:.:|.     .||.:...:|.       .:.|..
  Rat   693 PWEA-----------ALSSLN------YFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNNWL 740

  Fly   708 HRPV----------IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE--------RETVVCT 754
            .||.          .|..||...|..|     |:.:.|...:  ||...:        |.||.|.
  Rat   741 DRPPTLMEQYNEINAISTACSSGLEEC-----RDLVVGLYSQ--WMNNSDNNPIHPNLRSTVYCN 798

  Fly   755 AVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFK 819
            |:.||.|.:.:.....::::....|.:.|.:|||||..|:.|.|.|.:|.....:|||:|..|..
  Rat   799 AIAFGGEEEWNFAWEQFRKATLVNEADKLRSALACSNEVWILNRYLSYTLNPDYIRKQDATSTIV 863

  Fly   820 AVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDM 884
            ::.:|.:|..|...:|..|.:.:.......:....||:..:....|:..||....:|.::.....
  Rat   864 SIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKEDNSATG 928

  Fly   885 NGS-ERLIKILLERGNDNIHWQRTKFRPMLQAIRDIIL-W 922
            .|| .|.::..||:...||.|.:..        :|::| |
  Rat   929 FGSGTRALEQALEKTKANIKWVKEN--------KDVVLKW 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	130/411 (32%)
		M1_APN_2	33..493	CDD:189008	143/475 (30%)
		ERAP1_C	579..897	CDD:288671	87/348 (25%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68
		Metalloprotease	69..965		261/949 (28%)
		Peptidase_M1	75..479	CDD:279741	130/412 (32%)
		M1_APN_2	84..550	CDD:189008	143/474 (30%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		0/3 (0%)
		ERAP1_C	619..942	CDD:288671	87/348 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850