Protein Alignment CG2111 and Erap1

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_109636.1
• Gene: Erap1 / 80898
• MGIID: 1933403
• Length: 930
• Species: Mus musculus
• Alignment Length: 972
• Identity: 253/972 - (26%)
• Similarity: 427/972 - (43%)
• Gaps: 130/972 - (13%)

  Fly    16 LEANKTAVG--------RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAH 72
            :|:.|.:.|        |||:::.|:.|  |::...|.....|.|...:::.:.|.|..|::::|
Mouse    25 IESLKASNGDSFPWNNMRLPEYMTPIHY--DLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSH 87

  Fly    73 DLAIGK---RRAV--TLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRN 132
            .|.|.|   ||..  .||::     |:..::.... .::.:...:||.....|::.:.:.:.|..
Mouse    88 HLQISKATLRRGAGEMLSEE-----PLKVLEYPAH-EQVALLAAQPLLAGSLYTVIIDYAANLSE 146

  Fly   133 DNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPV 197
            ...|||.|.|......: :.||||||||..||.||||||:|..:..|.|.:.....:.|:||||:
Mouse   147 SFHGFYKSTYRTQEGEM-RILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPL 210

  Fly   198 QRTIRHASLKDYVWTQFVESH-----PMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALS 257
            .:::..|.       ..:|.|     .|.||||||:||.|  ...:...:|...:|.:|.||.::
Mouse   211 VKSVNVAE-------GLIEDHFDITVKMSTYLVAFIISDF--KSVSKMTKSGVKVSVYAVPDKIN 266

  Fly   258 QTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSID 322
            |.::|......||.||||.||..|...|.||.|:|||...:.|||||..:.|.|||||.::||..
Mouse   267 QADYALDAAVTLLEFYEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSAS 331

  Fly   323 DQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLS 387
            .:.|:...|:..:.:|||||||::.||:::||...||.::....|....||...:: :......:
Mouse   332 SKLGITMIVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVED-YFFGKCFN 395

  Fly   388 VLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANR 452
            .::.||..::..|:..|.:.:.|...::::...|.|.:..||...:..:.:...:.:||..|:.:
Mouse   396 AMEVDALNSSHPVSTPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYK 460

  Fly   453 TATSSDFWDLLQLQVDRNGR-------------------LGKGLNITRIMKCWLGQPGYPLVTVT 498
            ...:.|.|:.:......:|.                   ..:.:::..:|..|..|.|:||:|:|
Mouse   461 NTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITIT 525

  Fly   499 RNYDHRTAIVSQQRFFITPQFRNRWARNP----CWWVPLSYTCPSCQHSEIISFSRWLTCPTSKP 559
              ...|...:.|:.:....:      |.|    .|.|||::.                   |||.
Mouse   526 --VSGRNVHMKQEHYMKGSE------RFPETGYLWHVPLTFI-------------------TSKS 563

  Fly   560 SSKSNTVLLEKLEA----EPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRA 620
            .|....:|..|.:.    |...||.|||.....:.|:|....|..|:..|.:.:  ..|...:||
Mouse   564 DSVQRFLLKTKTDVLILPEAVQWIKFNVGMNGYYIVHYADDGWASLSGLLKEAH--TTISSNDRA 626

  Fly   621 QLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEIS--FERINNVAKSNPNYLIFKTYM 683
            .|:::.|.|.....:..:.||.:..||::|        |||.  |:.:|.:.   |.|.:.:...
Mouse   627 SLINNAFQLVSIEKLSIEKALDLTLYLKNE--------TEIMPIFQALNELI---PMYKLMEKRD 680

  Fly   684 RLLLERQF--------KRVISSDLTSSSGNMTHRPV---IIRLACEYELPACVSLARREFMKGTP 737
            .:.:|.||        |.:|.....:..|:::.|.:   ::.|||......||..|.|.|.:...
Mouse   681 MIEVETQFKDFLLKLLKDLIDKQTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYFREWKS 745

  Fly   738 EKGGWMTIRERETVVCTAV-KFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLI 801
            ..|. |:|....|:...|| ...||| .|.:.|.|:.|..:.||..:..:|..|::...||.:|.
Mouse   746 SNGN-MSIPIDVTLAVFAVGAQNTEG-WDFLYSKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLD 808

  Fly   802 WTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLST 866
            .:|:...::.|........:..|.:||.||.|::..|...:.......:..:.:::....:..||
Mouse   809 QSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHMVMGTTDQFST 873

  Fly   867 PKELLYFSKFFKEILRDMNGSE-RLIKILLERGNDNIHWQRTKFRPMLQAIRDIILWRSRAK 927
            ...|.....||..:..  |||: |.::..:|...:||.|....|    ..||   ||..:.|
Mouse   874 RARLEEVKGFFSSLKE--NGSQLRCVQQTIETIEENIRWMDKNF----DKIR---LWLQKEK 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	133/482 (28%)
		ERAP1_C	578..897	CDD:463368	81/333 (24%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	134/483 (28%)
		ERAP1_C	586..905	CDD:463368	82/335 (24%)