DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Erap1

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	253/979 - (25%)
Similarity:	430/979 - (43%)	Gaps:	140/979 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||:::.|:.|  |::...|.....|.|...:::...:.|..|::::|.|.|.|   .||.....
  Rat    42 RLPEYITPIHY--DLMIHANLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQISK---ATLRRGAE 101

  Fly    90 NSVPVSSIQMDIKLSRLTVSL--KRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQ- 151
            ..:|...:::....:...|:|  .:||.....|::.:.:.:.|..:..|||.|.|      .||
  Rat   102 EMLPEEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTY------RTQE 160

  Fly   152 ----WLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWT 212
                .||||||||..||.||||||:|..:..|.|.:.....:.|:||||:.:::..|.
  Rat   161 GERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAE------- 218

  Fly   213 QFVESH-----PMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSF 272
            ..:|.|     .|.||||||:||.|  ...:...:|...:|.:|.||.::|.::|......||.|
  Rat   219 GLIEDHFDITVKMSTYLVAFIISDF--KSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEF 281

  Fly   273 YEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVN 337
            |||.|:..|...|.||.|:|||...:.|||||..:.|.:||||.::||...:.|:...|:..:.:
  Rat   282 YEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAH 346

  Fly   338 QWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDY-----------------------QER 379
            |||||||::.||:::||...||.::....|....||...                       :|.
  Rat   347 QWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGRAMERTEEE 411

  Fly   380 HALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRR 444
            :......:.::.||..::..|:..|.:.:.|...::|:...|.|.:..||...:..:.:...:.:
  Rat   412 YFFGKCFNAMEVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQ 476

  Fly   445 YLVVYANRTATSSDFWDLLQLQVDRNGR-------------------LGKGLNITRIMKCWLGQP 490
            ||..|:.:...:.|.|:.:......:|.                   ..:.::|..:|..|..|.
  Rat   477 YLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQK 541

  Fly   491 GYPLVTVTRNYDHRTAIVSQQRFF----ITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRW 551
            |:||:|:|  ...|...:.|:.:.    ..|:      ....|.|||::..     |:..|..|:
  Rat   542 GFPLITIT--VRGRNVHLKQEHYMKGSECFPE------TGSLWHVPLTFIT-----SKSDSVQRF 593

  Fly   552 LTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHR 616
            |.      .:|::.::|    .|..:||.|||.....:.|:|....|..||..|.:.:  ..|..
  Rat   594 LL------KTKTDVIIL----PEAVEWIKFNVGMNGYYIVHYGDDGWASLNGLLKEAH--TTISS 646

  Fly   617 VNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEIS--FERINNVAKSNPNYLIF 679
            .:||.|:::.|.|...|.:..:.||.::.||::|        |||.  |:.:|.:.   |.|.:.
  Rat   647 NDRASLINNAFQLVSIGKLSIEKALDLILYLKNE--------TEIMPIFQGLNELI---PMYKLM 700

  Fly   680 KTYMRLLLERQF--------KRVISSDLTSSSGNMTHRPV---IIRLACEYELPACVSLARREFM 733
            :....:.:|.||        |.:|:....:..|:::.|.:   ::.|||.:....||..|.|.|.
  Rat   701 EKRDMVEVETQFKDFLLRLLKDLINKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYFR 765

  Fly   734 KGTPEKGGWMTIRERETVVCTAV-KFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQ 797
            :.....|. |::....|:...|| ...||| .|.:.|.|:.|..:.||..:..:|..|::...||
  Rat   766 EWKASNGN-MSLPIDVTLAVFAVGAQNTEG-WDFLYSKYQSSLSSTEKSQIEFSLCISQDPEKLQ 828

  Fly   798 RVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIE 862
            .:|..:|:...::.|........:..|.:||.||.|::..|...|.......:..:.:::.....
  Rat   829 WLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSSIAHMVMGTTN 893

  Fly   863 CLSTPKELLYFSKFFKEILRDMNGSE-RLIKILLERGNDNIHWQRTKFRPMLQAIRDIILWRSRA 926
            ..||...|.....||..:.:  |||: |.::..:|...:||.|....|    ..||   ||..:.
  Rat   894 QFSTRARLEEVKGFFSSLKK--NGSQLRCVQQTIETIEENIRWMDKNF----DKIR---LWLQKE 949

  Fly   927 KRIL 930
            ::.|
  Rat   950 RQEL 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	127/430 (30%)
		M1_APN_2	33..493	CDD:189008	138/513 (27%)
		ERAP1_C	579..897	CDD:288671	82/332 (25%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	127/431 (29%)
		M1_APN_2	50..544	CDD:189008	138/513 (27%)
		ERAP1_C	611..927	CDD:288671	82/332 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850