DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2111 and npepps

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	209/853 - (24%)
Similarity:	358/853 - (41%)	Gaps:	98/853 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSY----RVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLS 85
            |||..:.|::|    :.|::.      ..|.|.:...:..:.:|.:||:|..|:.|     :|.|
Frog     9 RLPTDVRPVNYGLCLKPDLID------FTFEGKLEATVEVQNATNQIVMNCADIDI-----ITAS 62

  Fly    86 --DKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTT 148
              .:....:..:......:..::|:|....|:.... .:::.|...|.:...|||.|.|.. .|.
Frog    63 YAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQKGAG-MLKIDFVGELNDKMKGFYRSKYAT-ATG 125

  Fly   149 LTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQ 213
            ..::.|.||||...||.||||:|:|..:..|.:.|..|....|||||.:.....:...::.|..:
Frog   126 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDVILIVPKDRVALSNMNLIDRKPYPDDENLVEVK 190

  Fly   214 FVESHPMQTYLVAFMISKFDRPGFTSSERSD-CPISTWARPDALSQTEFANMVVAPLLSFYEDLF 277
            |..:..|.||||||::.::|   |..:..|| ..:..:.......|.:||..|.|..|.||:|.|
Frog   191 FARTPIMSTYLVAFVVGEYD---FVETRSSDGVLVRVYTPVGKAEQGKFALEVAAKTLPFYKDYF 252

  Fly   278 NSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGN 342
            |..|...||||:|:.||...:.|||||..:.|.:||.|.:.|....:|.||..|...:.:|||||
Frog   253 NVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGN 317

  Fly   343 LVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDE 407
            ||::.||..:||...||.::....|....||:|...:.....|....:.||..|:..:..||...
Frog   318 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALENSHPIEVSVGHP 382

  Fly   408 SHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGR 472
            |.:...::.|...|.|.:..|||..:|:|.:...:.:||..:..:.|.:.|.|:.|:
Frog   383 SEVDEIFDAISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATEDLWESLE-------- 439

  Fly   473 LGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAI--VSQQRFFIT--PQFRNRWARNPCWWVPL 533
            ...|..|..:|..|..|.|:||:.|.......:.:  :||::|..:  |...:.:.    |.||:
Frog   440 QASGKPIAAVMNTWTKQMGFPLICVESEQKEDSVVLKLSQKKFCASGAPNSDDSYQ----WMVPI 500

  Fly   534 SYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLE-------AEPTDWILFNVQHTAPFRV 591
            |                  .|.:..|:|.:..:|::|.|       .:|..|:..|......:|.
Frog   501 S------------------ICTSESPASATVKILMDKPEMTVVLEGVKPHQWVKLNPGTVGFYRT 547

  Fly   592 NYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVW 656
            .|.....:.|...:.|.:    :..|:|..|.:||||||.:|.|.....|.::....:|..:.||
Frog   548 QYSTTMLESLLPGIRDLS----LQPVDRLGLQNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVW 608

  Fly   657 VATEISFERINNVAKSNPNYLIFKTYMRLLL--------------ERQFKRVISSDLTSSSGNMT 707
            .....:...::.:......:...:.::|.:.              |.....::...:....|...
Frog   609 SDLSCNLGILSTLLSHTDFHEEIQCFVRDVFSPIGQRLGWDPKPGEGHLDALLRGLVLGKLGKAG 673

  Fly   708 HRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYK 772
            |:|.:             ..|||.| |...:....::...|..|..|.:|.|.....:.:..::|
Frog   674 HQPTL-------------EEARRRF-KEHVDGRNVLSADLRSPVYVTVLKHGDNSTLETMMKLHK 724

  Fly   773 RSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNS-MGYRLAKKYVS 836
            :::...||..:...|........:::||.::. |..||.|:.......|...| :|.:.|..:|.
Frog   725 QADMQEEKNRIERVLGAIAEQDLIKKVLSFSL-SEDVRPQDTVCVIGGVAGGSKLGRKCAWNFVK 788

  Fly   837 VNMQNIRN 844
            .|.:.:.|
Frog   789 DNWEELYN 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	119/402 (30%)
		M1_APN_2	33..493	CDD:189008	134/466 (29%)
		ERAP1_C	579..897	CDD:288671	52/281 (19%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	119/403 (30%)
		M1_APN_2	17..460	CDD:189008	134/466 (29%)
		ERAP1_C	535..846	CDD:288671	52/281 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010