Protein Alignment CG2111 and ERAP2

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 935
• Identity: 260/935 - (27%)
• Similarity: 421/935 - (45%)
• Gaps: 113/935 - (12%)

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSD--- 86
            |||..::||.|  |:....|.....|..:..|::....:|:.|:|::.||.|......:..|
Human    68 RLPSVVIPLHY--DLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRY 130

  Fly    87 -KNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTL- 149
             |.|..:.|.|.....:::.|   :...|..::.|.:.:.|.:.|.:...|||.|.|    .||
Human   131 MKPGKELKVLSYPAHEQIALL---VPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTY----RTLG 188

  Fly   150 --TQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTI--RHASLKDYV 210
              |:.||.|.|||..||.||||||:|:|:..|.|.:.....:.||||||..:||  ....|:|:
Human   189 GETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDH- 252

  Fly   211 WTQFVESHPMQTYLVAFMISKF-DRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYE 274
               |..:..|.|||||:::..| ...||||   |...:|.:|.||..:||.:|......||.|||
Human   253 ---FETTVKMSTYLVAYIVCDFHSLSGFTS---SGVKVSIYASPDKRNQTHYALQASLKLLDFYE 311

  Fly   275 DLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQW 339
            ..|:..|...|:||:|:|||...:.|||||..:.|.|||:|.:.||..|:..|.|.:|..:.:||
Human   312 KYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQW 376

  Fly   340 FGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASV 404
            |||||::.||::||||..||.|:....|::..||..:.: :.|.:...|:..|:..::..::...
Human   377 FGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDD-YFLNVCFEVITKDSLNSSRPISKPA 440

  Fly   405 PDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQ---LQ 466
            ...:.|...::|:...|.|.:..||...:|||.:...:.:||..::.|.|.:.|.|..|.   |:
Human   441 ETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLE 505

  Fly   467 VDRNGR----------------LGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFF- 514
            .|....                ||:...:..:|..|..|.|.||:.|.:  |..:..:.|:||.
Human   506 SDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQ--DGCSLRLQQERFLQ 568

  Fly   515 ----ITPQFRNRWARNPCWWVPLSYTCPSCQ--HSEIISFSRWLTCPTSKPSSKSNTVLLEKLEA 573
                ..|::|....|. .|.:||:|:..|..  |..|:             .||::|:.|    .
Human   569 GVFQEDPEWRALQERY-LWHIPLTYSTSSSNVIHRHIL-------------KSKTDTLDL----P 615

  Fly   574 EPTDWILFNVQHTAPFRVNYDLRNWQLL------NKTLADPNKFRLIHRVNRAQLVDDLFSLAWS 632
            |.|.|:.|||.....:.|:|:...|..|      |.||..|.        :|..|:.|:|.|..:
Human   616 EKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPK--------DRVGLIHDVFQLVGA 672

  Fly   633 GDIEYDMALGILGYLEHEDE---FVVWVATEISF------ERINNVAKSNPNYLIFKTYMRLLLE 688
            |.:..|.||.:..||:||..   .:..::...||      ..|::::::...||:
Human   673 GRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLL---------- 727

  Fly   689 RQFKRVISSDLTSSSGNMTH---RPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERET 750
            :.||.||.....|..|::..   |..:::|||:.....|:..|...|.:.. |..|.:.|.....
Human   728 QYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWM-ESSGKLNIPTDVL 791

  Fly   751 VVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNAR 815
            .:..:|...|....:.:...|:.|..:||:..:|.||:.|::...|.:::....|...::.||..
Human   792 KIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLA 856

  Fly   816 RTFKAVVSNSMGYRLAKKYVSVNMQN-IRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKE 879
            ....|:.....|.:||..:|..|..: ::.:...|.|  :.::........:.|:.|...|.|.|
Human   857 ALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYD--IRMIISGTTAHFSSKDKLQEVKLFFE 919

  Fly   880 ILRDMNGSERLIKILLERGNDNIHW 904
            .|........:.:.:||....||.|
Human   920 SLEAQGSHLDIFQTVLETITKNIKW 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	151/482 (31%)
		ERAP1_C	578..897	CDD:463368	75/337 (22%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	152/483 (31%)
		ERAP1_C	620..938	CDD:463368	76/338 (22%)