DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2111 and ERAP2

DIOPT Version :9

Sequence 1:NP_572644.1 Gene:CG2111 / 31995 FlyBaseID:FBgn0030223 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001123612.1 Gene:ERAP2 / 64167 HGNCID:29499 Length:960 Species:Homo sapiens


Alignment Length:935 Identity:260/935 - (27%)
Similarity:421/935 - (45%) Gaps:113/935 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSD--- 86
            |||..::||.|  |:....|.....|..:..|::....:|:.|:|::.||.|......:..|   
Human    68 RLPSVVIPLHY--DLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRY 130

  Fly    87 -KNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTL- 149
             |.|..:.|.|.....:::.|   :...|..::.|.:.:.|.:.|.:...|||.|.|    .|| 
Human   131 MKPGKELKVLSYPAHEQIALL---VPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTY----RTLG 188

  Fly   150 --TQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTI--RHASLKDYV 210
              |:.||.|.|||..||.||||||:|:|:..|.|.:.....:.||||||..:||  ....|:|: 
Human   189 GETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDH- 252

  Fly   211 WTQFVESHPMQTYLVAFMISKF-DRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYE 274
               |..:..|.|||||:::..| ...||||   |...:|.:|.||..:||.:|......||.|||
Human   253 ---FETTVKMSTYLVAYIVCDFHSLSGFTS---SGVKVSIYASPDKRNQTHYALQASLKLLDFYE 311

  Fly   275 DLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQW 339
            ..|:..|...|:||:|:|||...:.|||||..:.|.|||:|.:.||..|:..|.|.:|..:.:||
Human   312 KYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQW 376

  Fly   340 FGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASV 404
            |||||::.||::||||..||.|:....|::..||..:.: :.|.:...|:..|:..::..::...
Human   377 FGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDD-YFLNVCFEVITKDSLNSSRPISKPA 440

  Fly   405 PDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQ---LQ 466
            ...:.|...::|:...|.|.:..||...:|||.:...:.:||..::.|.|.:.|.|..|.   |:
Human   441 ETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLE 505

  Fly   467 VDRNGR----------------LGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFF- 514
            .|....                ||:...:..:|..|..|.|.||:.|.:  |..:..:.|:||. 
Human   506 SDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQ--DGCSLRLQQERFLQ 568

  Fly   515 ----ITPQFRNRWARNPCWWVPLSYTCPSCQ--HSEIISFSRWLTCPTSKPSSKSNTVLLEKLEA 573
                ..|::|....|. .|.:||:|:..|..  |..|:             .||::|:.|    .
Human   569 GVFQEDPEWRALQERY-LWHIPLTYSTSSSNVIHRHIL-------------KSKTDTLDL----P 615

  Fly   574 EPTDWILFNVQHTAPFRVNYDLRNWQLL------NKTLADPNKFRLIHRVNRAQLVDDLFSLAWS 632
            |.|.|:.|||.....:.|:|:...|..|      |.||..|.        :|..|:.|:|.|..:
Human   616 EKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPK--------DRVGLIHDVFQLVGA 672

  Fly   633 GDIEYDMALGILGYLEHEDE---FVVWVATEISF------ERINNVAKSNPNYLIFKTYMRLLLE 688
            |.:..|.||.:..||:||..   .:..::...||      ..|::::::...||:          
Human   673 GRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLL---------- 727

  Fly   689 RQFKRVISSDLTSSSGNMTH---RPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERET 750
            :.||.||.....|..|::..   |..:::|||:.....|:..|...|.:.. |..|.:.|.....
Human   728 QYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWM-ESSGKLNIPTDVL 791

  Fly   751 VVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNAR 815
            .:..:|...|....:.:...|:.|..:||:..:|.||:.|::...|.:::....|...::.||..
Human   792 KIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLA 856

  Fly   816 RTFKAVVSNSMGYRLAKKYVSVNMQN-IRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKE 879
            ....|:.....|.:||..:|..|..: ::.:...|.|  :.::........:.|:.|...|.|.|
Human   857 ALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYD--IRMIISGTTAHFSSKDKLQEVKLFFE 919

  Fly   880 ILRDMNGSERLIKILLERGNDNIHW 904
            .|........:.:.:||....||.|
Human   920 SLEAQGSHLDIFQTVLETITKNIKW 944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2111NP_572644.1 Peptidase_M1 25..421 CDD:279741 136/405 (34%)
M1_APN_2 33..493 CDD:189008 154/488 (32%)
ERAP1_C 579..897 CDD:288671 74/336 (22%)
ERAP2NP_001123612.1 Peptidase_M1 68..458 CDD:279741 136/406 (33%)
M1_APN_2 76..548 CDD:189008 154/488 (32%)
Substrate binding 334..338 0/3 (0%)
ERAP1_C 621..938 CDD:288671 75/337 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155364
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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