DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Enpep

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	242/905 - (26%)
Similarity:	415/905 - (45%)	Gaps:	84/905 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||.::.|:.|  |:..::......:.|.|.|.:...:.|:.:.|:..:..|.|  ...|...:|
  Rat    84 RLPDFIQPVHY--DLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRITK--LPELRRPSG 144

  Fly    90 NSVPVSSIQMDIKLSRLTVSLKRPLKV---NVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQ 151
            ..||:.......|...:.:..:..|..   :..|.:.:.|...|.....|||.:.|.:...|.:
  Rat   145 EQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTEDGQTKS- 208

  Fly   152 WLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQR--TIRHASLKDYVWTQF 214
             :|||..||..||::|||||:|..:..:.|:|.||..|.|||||||::  |:.:    |:..|.|
  Rat   209 -IAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKEETLDN----DWKKTTF 268

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNS 279
            ::|.||.||||.|.:.:|.....||  ||..|::.:.:|:.....|:|..:...:..|:||.|..
  Rat   269 MKSVPMSTYLVCFAVHQFTSIQRTS--RSGKPLTVYVQPNQKQTAEYAANITKAVFDFFEDYFAM 331

  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344
            .|...|:|.:|:|||...:.|||||..:.|.:||||...|:..:||.||..||..:|:|||||:|
  Rat   332 EYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNIV 396

  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESH 409
            ::.||.::||...||.:....||:....:|....:..|:..|.|.:.|:.:::..|..:|...:.
  Rat   397 TMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVVVTVSTPAE 461

  Fly   410 IWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLG 474
            |.:.::.|...|.|.:..||...:..|.:....:.||..:..:.|.:|||||.|:
  Rat   462 ITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSLE---------- 516

  Fly   475 KGLN--ITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNP-----CWWVP 532
            |..|  :..:|..|..|.|||:|||:...:     |:|:||.:  .::...::.|     .|.:|
  Rat   517 KASNQPVKEVMDTWTSQMGYPVVTVSGKQN-----VTQKRFLL--DYKADPSQPPSALGYTWNIP 574

  Fly   533 LSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRN 597
            :.:|  ...:|.|..:.|         |::....|...|..:  .::..|..|...:||||:...
  Rat   575 IKWT--ENGNSNITVYYR---------SNREGITLNANLSGD--GFLKINPDHIGFYRVNYEAET 626

  Fly   598 WQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVW--VATE 660
            |..:.:||:  :........:|:..:||.|:||.:..::|:.||.:..||..|.:|:.|  |.:.
  Rat   627 WDWIAETLS--SNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISA 689

  Fly   661 ISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISS---DLTSSSGNMTHRPVIIRLACEYELP 722
            :|: .|:........|.:.:||.|    .|.|.:..|   ..|.|......|..::..||:....
  Rat   690 VSY-IISMFEDDRELYPLIETYFR----SQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAG 749

  Fly   723 ACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKF-------GTEGDRDMVESMYKRSNFAAEK 780
            ..:..|.:.|       ..|:...|...|....:.:       |.|...:.....|::::.|.||
  Rat   750 EALGNASQLF-------EAWLKGNESIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEK 807

  Fly   781 ESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRN- 844
            |.||..||..::|..|.|.|....:.:.::.|:.....:.:..||.|..:|..::.:|...:.|
  Rat   808 EKLLYGLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNR 872

  Fly   845 YCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHW 904
            :..|  |:.:..:..:.|..:|..:|.....||.:......|::...:: ||...:||.|
  Rat   873 FTIN--DRYLGRIVTIAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQV-LETVKNNIEW 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	125/400 (31%)
		M1_APN_2	33..493	CDD:189008	141/466 (30%)
		ERAP1_C	579..897	CDD:288671	74/330 (22%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	125/401 (31%)
		M1_APN_2	92..537	CDD:189008	141/466 (30%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		0/3 (0%)
		ERAP1_C	608..922	CDD:288671	74/330 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020