DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and RNPEP

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_064601.3	Gene:	RNPEP / 6051	HGNCID:	10078	Length:	650	Species:	Homo sapiens

Alignment Length:	507	Identity:	122/507 - (24%)
Similarity:	184/507 - (36%)	Gaps:	143/507 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GTVVIDLR--SERSTKRIVLNAH---DLAIGKRRAVTLSDKNGNSVPVSSIQMDIKL--SRLTVS 109
            ||.|:|||  .......:.|::|   ::.....|......:...:.|||........  ..|.||
Human    61 GTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVS 125

  Fly   110 LKRP------LKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAA------------T 156
            ..:|      |:|.:||.:         .:..|             ..|||.            |
Human   126 FPQPCRAAERLQVLLTYRV---------GEGPG-------------VCWLAPEQTAGKKKPFVYT 168

  Fly   157 QFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQ-------F 214
            |.:....|..|||||.|          |..|.|.||..:|...|   |.:....|.:       |
Human   169 QGQAVLNRAFFPCFDTP----------AVKYKYSALIEVPDGFT---AVMSASTWEKRGPNKFFF 220

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSE---RSDCPISTWARP---DALSQTEFANMVVAPLLSFY 273
            ....|:.:||:|..|.     ...|:|   ||    ..||.|   || ::.|: |.|:...|:..
Human   221 QMCQPIPSYLIALAIG-----DLVSAEVGPRS----RVWAEPCLIDA-AKEEY-NGVIEEFLATG 274

  Fly   274 EDLFNSTYRQKKIDLVAL-PDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVN 337
            |.|| ..|...:.||:.: |.|.|...||..| .|....||...            |::|.::::
Human   275 EKLF-GPYVWGRYDLLFMPPSFPFGGMENPCL-TFVTPCLLAGD------------RSLADVIIH 325

  Fly   338 Q----WFGNLVSVAWWHEIWLKNVFALYLSR------FGVHSLRPEWDYQE----RHALQLYLSV 388
            :    ||||||:.|.|.|.||...|.:|..|      ||.     .:...|    |..|:.::.:
Human   326 EISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGA-----AYTCLEAATGRALLRQHMDI 385

  Fly   389 LDYDAHVN---TDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTA-LRRYLVVY 449
            ...:..:|   ..:.....||::     |||....|.......|..::|::....: |:.|:..:
Human   386 TGEENPLNKLRVKIEPGVDPDDT-----YNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEF 445

  Fly   450 ANRTATSSDFWD--------LLQLQVDRNGRLGKGLNITRIMKCWLGQPGYP 493
            ..|:..:.||.|        |.:.:||    :..|....|    ||..||:|
Human   446 KFRSILADDFLDFYLEYFPELKKKRVD----IIPGFEFDR----WLNTPGWP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	103/424 (24%)
		M1_APN_2	33..493	CDD:189008	121/505 (24%)
		ERAP1_C	579..897	CDD:288671
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	122/507 (24%)
		M1_LTA4H	24..484	CDD:189006	118/500 (24%)
		Substrate binding. /evidence=ECO:0000250	298..302		0/3 (0%)
		Leuk-A4-hydro_C	504..644	CDD:286244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740