Protein Alignment CG2111 and RNPEPL1

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 756
• Identity: 151/756 - (19%)
• Similarity: 241/756 - (31%)
• Gaps: 292/756 - (38%)

  Fly    32 PLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGNSVPVSS 96
            ||::|||       |:..:|.::.:.|..|       |.||
Human   134 PLAFRVD-------PFTDYGSSLTVTLPPE-------LQAH------------------------ 160

  Fly    97 IQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAAT-QFEP 160
                           :|.:|            :||..:|...:..::|  ..||...|.. .|..
Human   161 ---------------QPFQV------------ILRYTSTDAPAIWWLD--PELTYGCAKPFVFTQ 196

  Fly   161 NHA---REAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFVESHPMQT 222
            .|:   |..|||||.|..:..:...:..|...:.|.:     ..|.|.:::.....|...||:..
Human   197 GHSVCNRSFFPCFDTPAVKCTYSAVVKAPSGVQVLMS-----ATRSAYMEEEGVFHFHMEHPVPA 256

  Fly   223 YLVAFMISKFDRPGFTSSERSDCPISTWARPDAL-SQTEFANMVVAPLLSFYEDLFNSTYRQKKI 286
            ||||.:.............|      .||.|..| :.|...:..|...||..|.|: ..|...:.
Human   257 YLVALVAGDLKPADIGPRSR------VWAEPCLLPTATSKLSGAVEQWLSAAERLY-GPYMWGRY 314

  Fly   287 DLVAL-PDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWH 350
            |:|.| |.|...:.||..| .|...|:|...:...||        |...|.:.||||.|:.|.|.
Human   315 DIVFLPPSFPIVAMENPCL-TFIISSILESDEFLVID--------VIHEVAHSWFGNAVTNATWE 370

  Fly   351 EIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYN 415
            |:||....|.|.              |.|...:.|                         .||:.
Human   371 EMWLSEGLATYA--------------QRRITTETY-------------------------GAAFT 396

  Fly   416 EIGERKAAVLFEMLHR---VMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGL 477
            .:   :.|...:.|||   ::||::                       .:.:|||    :|..|:
Human   397 CL---ETAFRLDALHRQMKLLGEDS-----------------------PVSKLQV----KLEPGV 431

  Fly   478 NITRIMKCWLGQPGYPLV--------------TVTRNYDHR---TAIVSQQ------RFFITPQF 519
            |.:.:|..:..:.||..|              ...|.|..:   |::|:|.      .||  |:.
Human   432 NPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFF--PEL 494

  Fly   520 RNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTC---PTSKPSSKSNTVLLEKLE-------AE 574
            :.:           |..|.:.     :.|.|||..   |.::|.....:.|...:|       ||
Human   495 KEQ-----------SVDCRAG-----LEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAE 543

  Fly   575 PTD-------------WILFNVQHTAPF---------------------------RVNYDLR-NW 598
            |.|             |..|   .||.|                           .:|.::| .|
Human   544 PLDQAAASASAIDISKWRTF---QTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIRIRW 605

  Fly   599 -QLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEIS 662
             |::.:....|:    :|||.|  .::...|..::..:..|:..|.|...          |.|:.
Human   606 LQIVVRNDYYPD----LHRVRR--FLESQMSRMYTIPLYEDLCTGALKSF----------ALEVF 654

  Fly   663 FERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSS 703
            ::   ...:.:||           |.|..::::|..|.||:
Human   655 YQ---TQGRLHPN-----------LRRAIQQILSQGLGSST 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	97/462 (21%)
		ERAP1_C	578..897	CDD:463368	28/155 (18%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	114/552 (21%)
		Leuk-A4-hydro_C	560..673	CDD:462686	24/145 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699		3/6 (50%)