Protein Alignment CG2111 and erap1a

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: XP_692516.3
• Gene: erap1a / 564068
• ZFINID: ZDB-GENE-091113-7
• Length: 933
• Species: Danio rerio
• Alignment Length: 995
• Identity: 266/995 - (26%)
• Similarity: 434/995 - (43%)
• Gaps: 152/995 - (15%)

  Fly     2 HLSYLTILTALF-----FHLEANKTAVG------RLPKWLVPLSYRVDIVTRINQPYQPFGGTVV 55
            |.:.:.:..|||     ..:..|||.:.      |||:.:.|..|  |::...|.....|.|.|.
Zfish     9 HFTLVALFCALFAGNHAMTVNKNKTVLPFPWDKMRLPEIVKPQHY--DLLIHPNLTSLTFTGEVQ 71

  Fly    56 IDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPL-KVNVT 119
            |.:..::.|:.|:|::.:|.:.|  |:.|..:..:.      ..|:::|....:.:..| ....|
Zfish    72 IQIEVKQDTRAIILHSKNLQVSK--ALLLGSRQHHH------HQDLQISEFEANEQIALFSEGFT 128

  Fly   120 YS-----MRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPF 179
            :.     :.:.|.:.|.:...|||...|.. |:...:.||:|||||.|||.||||||:|.|:..|
Zfish   129 FEKGSHVVHLEFYANLSDSFHGFYKGQYTT-NSGEVRMLASTQFEPTHARAAFPCFDEPAFKANF 192

  Fly   180 KINLAHPYLYRALSNMPVQRTIRHAS--LKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSER 242
            .|.:.....:.::||||..||:..|.  |:|    ||.....|.||||||:|..|.  ..:...:
Zfish   193 TIRVRRESRHISISNMPKLRTVELADGILED----QFDTMVKMSTYLVAFIICDFH--SISKKSQ 251

  Fly   243 SDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAF 307
            ....||.:..|:.:||.|:|......:|.||::.|:..|...|.||.|:|||...:.|||||..:
Zfish   252 HGVEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTY 316

  Fly   308 AEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRP 372
            .|..||:|.::||..|:.|:.:.:|..:.:|||||||::.||:::||...||.::....|:...|
Zfish   317 RESGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHP 381

  Fly   373 EWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEA 437
            |....: :.|:...:.|..|:..::..|:..|.:.:.|...::::..||.|.:..||...:..|.
Zfish   382 ELQVND-YFLEKCFTALSVDSLSSSHPVSTPVENPAEISEMFDDVSYRKGACILNMLRDFLTPEV 445

  Fly   438 WLTALRRYLVVYANRTATSSDFWDLL------------QLQVDRNGRLGK--------------G 476
            :...:..||..::.:...:|..|:.|            :|::|  |...|              .
Zfish   446 FKYGIINYLKKHSYQNTVNSHLWESLTNICTSDGLDSGRLKLD--GFCSKHTAETPASKWFKEDS 508

  Fly   477 LNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPSCQ 541
            :::..||..|..|.|:||:||  ....:...:.|:||....:..|  :.:..|.|||:|.
Zfish   509 VDVGAIMDTWTLQEGFPLITV--EVKGQEVTLKQERFLKGAESSN--SSSFLWQVPLTYI----- 564

  Fly   542 HSEIISFSRWLTCPTSKPSSKSNTV--LLEKLE------AEPTDWILFNVQHTAPFRVNYDLRNW 598
                              :|.||.|  .|.|.|      .|..:||.|||.....:.|:|:...|
Zfish   565 ------------------TSGSNAVQRFLLKTERDVFYLPEKVEWIKFNVDLRGYYIVHYESGGW 611

  Fly   599 QLLNKTLADPNKFRLIHRV----NRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEF--VVWV 657
            ..|.|.|      |:.|.|    :||.|:.|:|.|.....:..|.||.:..||..|.|.  |...
Zfish   612 DCLIKQL------RMNHTVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVTQG 670

  Fly   658 ATEI----------SFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTHRPV- 711
            .:|:          ..:.:.|..||:             |.:.|:.:|.....|.:|:::.|.:
Zfish   671 FSELVPLYKLMEKRDMQELENQLKSH-------------LVKLFQPLIDRQSWSDNGSVSERMLR 722

  Fly   712 --IIRLACEYELPACVSLARREFMKGTPEKGG-WMTIRERETVVCTAVKFGTEGDR-----DMVE 768
              ::..||....|:|||.|.:.|.|.....|. |:     .|.|...|.  |||.|     |.:.
Zfish   723 NYLLLFACVRRYPSCVSTATQLFHKWKESDGKMWL-----PTDVSLVVY--TEGARTDDGWDFLL 780

  Fly   769 SMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKK 833
            ..||||...:||..:..||:.|.....||.:|..:.|...::.|:......:|..|..|::||..
Zfish   781 EKYKRSVSPSEKWMIKAALSYSPLAHKLQWLLERSSEGEIMKTQDLPSMLISVSKNPKGFKLAWD 845

  Fly   834 YVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERG 898
            ::..|...:.......:..:..::..:.:..||.:.|.....||..:.:|.....|.|:..||:.
Zfish   846 FLKSNWGKLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSIQQALEKI 910

  Fly   899 NDNIHWQRTKFRPMLQAIRD 918
            ..||.|..... |:|:|..|
Zfish   911 QQNILWMDRNV-PLLKAWLD 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	137/487 (28%)
		ERAP1_C	578..897	CDD:463368	86/343 (25%)
erap1a	XP_692516.3	M1_APN-Q_like	52..520	CDD:341064	138/487 (28%)
		ERAP1_C	591..911	CDD:463368	87/345 (25%)