DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Lvrn

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	255/902 - (28%)
Similarity:	400/902 - (44%)	Gaps:	135/902 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTR-----INQPYQPFGGTVVIDLRSERSTKRIVLNAH-----------D 73
            |||.|||||.|.:::..|     ::.|...|.|.|.|.:|...:|..::|::.           .
  Rat    94 RLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFFLNYKQVEVWGP 158

  Fly    74 LAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFT-SVLRNDNTGF 137
            ||...|.|..      ..||:.::...:.:..:.:.|.:.|....:|.:...|: .||:..:.|.
  Rat   159 LAPDTRNATV------GRVPLENVWFALDMQYVVLDLGQSLDPGSSYELNFDFSGQVLQEGSEGL 217

  Fly   138 YSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIR 202
            :.:.|.|.:.  .:.|.|||.||..||..|||||:|..:..|.|.:.|...|.||||||......
  Rat   218 FLNLYTDEDQ--LRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSNMPQLGQSH 280

  Fly   203 HASLKDYVW--TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQ--TEFAN 263
            ...:....|  |.|..:..|.|||||.:|..||   :.|.......|..|||.|.::.  .:||.
  Rat   281 RIDVNGSRWTVTSFHTTPRMPTYLVALVICDFD---YVSRTERGKEIRVWARKDDIADGYLDFAA 342

  Fly   264 MVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVA 328
            ....|:.||.|||||.:|...|.|::|||.|...:.|||||..| :.|||.:     :||.....
  Rat   343 NHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-DASLLLE-----LDDDLPEK 401

  Fly   329 RAVAMMVV-----NQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSV 388
            ||:.:.::     :|||||||:::||:.|||...||.|......:...|:........|.:...:
  Rat   402 RAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKVPRNMIFFLTVLHDI 466

  Fly   389 LDYDAHVNTDLVTASVPDESHIWAAYNEIGE-------RKAAVLFEMLHRVMGEEAWLTALRRYL 446
            |:.|..:.:..|  |.|.|:  :....||..       :|.|.:..||...:.:..::.||:.||
  Rat   467 LEDDHSLESRAV--STPVEN--FTETREINRLFDIYTYKKGACMAWMLAGFLSQHLFINALKSYL 527

  Fly   447 VVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQ 511
            ..::...|...|.|..:|:.:|....:.....:.|||..|..|.|:|::|:..:    |.:|.|:
  Rat   528 ETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITLNAS----TGVVKQE 588

  Fly   512 RFFI------TPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLL-E 569
            .|::      |....|.|. .|.:|:....|.|..          ||        .||:.:.. .
  Rat   589 PFYLERVENQTLLSHNTWI-VPIFWMKNGITQPLV----------WL--------DKSSMIFPGM 634

  Fly   570 KLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTL-ADPNKFRLIHRVNRAQLVDDLFSLAWSG 633
            ||....:||::.|...|..:|||||...|:.||:.| .||   :.|..:||.|||.|.|:|:.:.
  Rat   635 KLSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQLEKDP---KAIPVINRLQLVSDAFALSKNN 696

  Fly   634 DIEYDMALGILGYLEHEDEFVVWVATEISFERIN-NVAKSNPNYLIFKTYMRLLLERQ------F 691
            .||.:.||.:..|:..|||.:||.  |:....|| .|.....||.::....:..|:|.      :
  Rat   697 YIEIETALDLTKYIAKEDEILVWF--EVLVNLINREVVYDVKNYYLYPLLKKYFLKRLNSIWTIY 759

  Fly   692 KRVISSDLTSSSGN-MTHRPV--IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE------ 747
            ..:|..::.|...| ::..|:  ....||...|..|:.|:|..|.|       ||...|
  Rat   760 SAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRK-------WMAHPETAIPPQ 817

  Fly   748 -RETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKES---LLTALACSRNVFALQRVL---IWTFE 805
             .:.|:|.|:..|:..|.|.:.::|  .|...|:|.   |:.|:.||::...|.|.:   |..|.
  Rat   818 IEKVVLCNAIALGSNKDWDFLFNLY--INKTEEQEDLFHLVHAMGCSKDPRTLNRFMEYDITVFP 880

  Fly   806 SSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIE 862
            |    :.|.....:.|..:.:|..:||.::..|.  :..|.|.|       ::||::
  Rat   881 S----RFNETNLIEVVAESEVGRYVAKDFLINNW--VAVYESPS-------LSPLLQ 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	130/428 (30%)
		M1_APN_2	33..493	CDD:189008	142/492 (29%)
		ERAP1_C	579..897	CDD:288671	85/308 (28%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	140/487 (29%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	81/291 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950