DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG11951

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	307/912 - (33%)
Similarity:	495/912 - (54%)	Gaps:	37/912 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQ-PFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKN 88
            |||..|.|.||.|.|:|::..|.. .|.|||.|.:...::|..|.|::.||.|.... :|||...
  Fly    26 RLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTE-ITLSQIG 89

  Fly    89 GNSVP---VSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLT 150
            |....   ::|..::.......::..:.|.....|.:.:.|::.|::...|:|.|:||:.....|
  Fly    90 GEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANET 154

  Fly   151 QWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFV 215
            :|::.|||||..||.||||||:|.::..|.|.|.:...|..||||||..|..|.|:.|||||.|.
  Fly   155 RWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYVWTSFE 219

  Fly   216 ESHPMQTYLVAFMISKFDRPGFTSSERSDCP----ISTWARPDALSQTEFANMVVAPLLSFYEDL 276
            ||.||.|||||:.::.|      |.:.|..|    ..|||||:|:.|.::|..:...:|.:||:|
  Fly   220 ESLPMSTYLVAYSLNDF------SHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEEL 278

  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341
            |...:...|:|.:|:|||:..:.|||||..|||.:|||..:.||.:.:|..|..||..:.:||||
  Fly   279 FGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFG 343

  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPD 406
            |||::.||.::||...||.|::...|..:.|:|...:..::...|::...|:..::..::..:..
  Fly   344 NLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPIEM 408

  Fly   407 ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNG 471
            .|.|..:::||..:|.:.:..|:|..:||||:.|.|:.||..|..:.|...:.|:.|.....:.|
  Fly   409 TSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTG 473

  Fly   472 RLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYT 536
            .|.|..||..||..|..|.|||::.|||:|..|||.:||:|:.:......  |...|||||||||
  Fly   474 SLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSR--AHKGCWWVPLSYT 536

  Fly   537 CPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLL 601
            ....:.....:...|:.| |....|...|:  ..|.. |..|::||.|.:||::||||.:||:||
  Fly   537 NQEEKDFNNTAPKEWMEC-TETGESVPKTI--HDLPG-PDQWVIFNNQLSAPYKVNYDAQNWKLL 597

  Fly   602 NKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERI 666
            .:|| :...:..||.||||||:||:...||:|:.:|::||.::.|||.|.|.:.|.:...:.:.:
  Fly   598 IETL-NSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFV 661

  Fly   667 NNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTHRPVIIRL----ACEYELPACVSL 727
            :.:.:..||:..||.:.|.|:...::.:...:.|.:|.....:.::..:    ||.:|:..||:.
  Fly   662 SGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVADWACSFEVSDCVTQ 726

  Fly   728 A----RREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALA 788
            |    |....:..|::...:.:..|..|.|||:|.|.:.|.|.:.:.|:::|.|.||:.:|.:|.
  Fly   727 ALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLG 791

  Fly   789 CSRNVFALQRVLIWTFESSG-VRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDK 852
            ||:.|:.|||.|...|:..| :|||::...|:|:..:.:|:.|||||:..|:.:|..:....::.
  Fly   792 CSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSES 856

  Fly   853 VVNLMTPLIECLSTPKELLYFSKFF---KEILRDMNGSERLIKILLERGNDNIHWQRTKFRPMLQ 914
            :..|:.||.|.:.|.::...|..|.   |:.|:|:   |:.|...||....|:.|:...:....:
  Fly   857 MSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDI---EQTISQSLETMLINVQWKERNYERFTR 918

  Fly   915 AI 916
            ||
  Fly   919 AI 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	143/403 (35%)
		M1_APN_2	33..493	CDD:189008	163/467 (35%)
		ERAP1_C	579..897	CDD:288671	104/329 (32%)
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	161/461 (35%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	106/331 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020