DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG14516

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	269/911 - (29%)
Similarity:	443/911 - (48%)	Gaps:	44/911 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGK-----RRAVTL 84
            |||..:.||.|.:.|..:::..: .|.|:|.|.:|.......|.::|.:|.|.:     .|....
  Fly   113 RLPHSIRPLKYNITIEPQLSGNF-TFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNN 176

  Fly    85 SDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTL 149
            .:..|:.:.:....:........:.|...|..:|.|.:.:.|..::.:...|||.|:|..||.
  Fly   177 GEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYEVHNE-- 239

  Fly   150 TQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQF 214
            |:|:|:|||:...||.||||||:|..:..|.:::|.|.....:||||:..:..||::..|||..|
  Fly   240 TRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHF 304

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNS 279
            .||.||.|||||:.||.|       :..|....:.|||.||:...|:|..|...:|:|.:|.||.
  Fly   305 AESLPMSTYLVAYAISDF-------THISSGNFAVWARADAIKSAEYALSVGPRILTFLQDFFNV 362

  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344
            |:...|||::|||:|...:.|||||..|.|.::|||...::.:::|.||..|...:.:|||||||
  Fly   363 TFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLV 427

  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESH 409
            :.:||.:|||...||.|:......::.|||...::..:....:|...||...:..::..|.:...
  Fly   428 TPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQE 492

  Fly   410 IWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLG 474
            |...::.|...|.:.:..|:...:....:...|.:||...|..:||..|.|..|.::...:|.|.
  Fly   493 ISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLD 557

  Fly   475 KGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPS 539
            ...::..||..|..|.|||:|.|:|:.:.....:.|.||..|...|.  ..:..|::|:::|..|
  Fly   558 DSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTRE--DESLLWYIPITFTTDS 620

  Fly   540 CQHSEIISFSRWLTCPTS-KPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNK 603
                 .::|:.  |.||: .|.:|  ...||..|.....|.:||||.|..:||||||.||..:.:
  Fly   621 -----ELNFAN--TRPTTWMPRTK--LYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITE 676

  Fly   604 TLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERINN 668
            .|.|.:.|..|...|||||:||:.:||....:.|:.|:.:..||.||...|.|.|...:|..|::
  Fly   677 HLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDS 741

  Fly   669 VAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNM---THRPVIIRLACEYELPACVSLARR 730
            :..::.:|.:.|.|:...|::.:.:|...|....|.::   ..|..|:.:||......|::.|.|
  Fly   742 MFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKRADILSMACHLGHQECIAEASR 806

  Fly   731 EFMK----GTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSR 791
            .|..    ..|:....:....|..|.|:|:::|||.:.|.....:.::|...||:.||.||.||:
  Fly   807 HFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSK 871

  Fly   792 NVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNL 856
            ..:.|.|.|........:|||:..|.|.||.:..:|..:|..::..|.|.|:.|..:....:..|
  Fly   872 EPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTL 936

  Fly   857 MTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHWQRTKFRPMLQAIRDIIL 921
            .....:..::..:|..|..|.|:...|.   :|.::.::|....::.|....:       :.|:.
  Fly   937 FKFATKGFNSKFQLGEFENFVKDAHWDY---DRPVQQIVEHIETSVDWMNKNY-------KSIVR 991

  Fly   922 W 922
            |
  Fly   992 W 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	130/400 (33%)
		M1_APN_2	33..493	CDD:189008	144/464 (31%)
		ERAP1_C	579..897	CDD:288671	93/324 (29%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	130/401 (32%)
		M1_APN_2	121..576	CDD:189008	144/464 (31%)
		ERAP1_C	652..974	CDD:288671	93/324 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462071
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850