DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG4467

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001036747.1	Gene:	CG4467 / 42747	FlyBaseID:	FBgn0039064	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	990	Identity:	219/990 - (22%)
Similarity:	385/990 - (38%)	Gaps:	220/990 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LPKWLVPLSYRVDI---VTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDK 87
            ||..:.||.|.|.|   :|.::     ..|.|.|||..|:.|..|||:..||.:.::..||...|
  Fly   138 LPTSVRPLRYMVTIHPNLTTLD-----VKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGPK 197

  Fly    88 NGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQW 152
             |.::.:..:.......:|.:.:|..||....|::.:.:.|.|..:..|||...|...| .:.:.
  Fly   198 -GYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESSN-GVERL 260

  Fly   153 LAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRT------IRHASLKDYVW 211
            ||||.|.||.||.||||||:|..|.||:|::.....:..|||..|..|      :....|:|
  Fly   261 LAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRD--- 322

  Fly   212 TQFVESHPMQTYLVAFMISKFDR----------------PG-------------FTSSERSDCPI 247
             .|:|:.|:....||:::|.|.|                ||             :|..:..:.|:
  Fly   323 -DFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPV 386

  Fly   248 ----------------------------STW-------ARPD---ALSQTEFANMVVAPLLSFY- 273
                                        :.|       .:|.   :|||:..:::..||..:||
  Fly   387 RNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYA 451

  Fly   274 -EDL---------------------FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDS 316
             .||                     .:.:|...|:|.||||........:.||... :.|.|.|.
  Fly   452 PRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTL-KTSFLTDP 515

  Fly   317 QRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRP---EWDYQE 378
            ...:.:..|..|..:|..:|.|:||.:.|.....::||......||   |:|:|.|   .|..:|
  Fly   516 SSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYL---GIHALAPLQETWPLRE 577

  Fly   379 RHALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALR 443
            .:.|::..:.||.||....|.:......:.:    ..|...:|.|.:|.|||..:||:.:...|.
  Fly   578 MYLLKMATAALDIDAIQGWDSIMNGTSHDGN----NEEFFVQKTAAIFSMLHTAIGEDRFRGCLG 638

  Fly   444 RYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTR--------- 499
            .:|.|...|||..:|.|.:...:.  ||    ..||..:|..|..|||:||:|||:
  Fly   639 SFLKVNRFRTAEPTDLWTICTKKA--NG----SKNIKDMMTLWTHQPGFPLLTVTKMGNSISISQ 697

  Fly   500 -------------------NYDHRTAIVSQQRFFI---TPQFRNRWARNPCWWVPLSYTCPSCQH 542
                               ||:..|...:.....:   |...:::.|.:..|..|::|.
  Fly   698 RPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYV------ 756

  Fly   543 SEIISFSRWLTCPTSKPSSKSNTVLLEKLEA-----EPTDWILFNVQHTAPFRVNYDLRNW-QLL 601
            ::|              ::.|.|:.::.::.     |...||..|......:||.|:..|| .|:
  Fly   757 TDI--------------NNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLI 807

  Fly   602 NKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERI 666
            .:..|:||:|.   ..:|..::.|.|:|..:..:..::.:.::.||..|..:..........|:.
  Fly   808 EELAANPNRFT---SEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKW 869

  Fly   667 NNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTH---RPVIIRLACEYELPACVSLA 728
            ..:.|.:..:|:...::::.:....::|..||    .|::..   ||.::..:..:|....::.|
  Fly   870 RRILKYSECFLMLSEFIKMKISTVMEKVGWSD----DGDVATRLLRPEVLLASVLWEDIDSITKA 930

  Fly   729 RREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMY------------KRSNFAAEKE 781
            :....:.....|..:....||.|...::..|        |.:|            :.|....|:.
  Fly   931 KNMLNQYLYYNGTAIPPNLREVVYTGSILSG--------EYIYWQHCWERFVNLQRTSETFVERM 987

  Fly   782 SLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYC 846
            .||.||..:::.:...|:|   ...:.:..:...:..||:.....|..:|.:::......:....
  Fly   988 QLLRALGRTKDAWLQNRLL---SHVTMLPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKRL 1049

  Fly   847 SNST---DKVVNLMT 858
            ...|   .||::.:|
  Fly  1050 GPGTISFAKVISAIT 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	123/496 (25%)
		M1_APN_2	33..493	CDD:189008	145/561 (26%)
		ERAP1_C	579..897	CDD:288671	53/299 (18%)
CG4467	NP_001036747.1	Peptidase_M1	138..593	CDD:279741	120/469 (26%)
		GluZincin	145..682	CDD:301352	145/561 (26%)
		ERAP1_C	784..1078	CDD:288671	53/299 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920