DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG31233

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	265/927 - (28%)
Similarity:	417/927 - (44%)	Gaps:	99/927 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||...:|..|.|.:.|.::.....|.|||.|.|....:|.:||::|..|   :....::..:..
  Fly    57 RLPYDTIPSHYAVSLSTNVHTGDTVFNGTVAITLSVLNTTTKIVVHARQL---ENFTASIIQQGV 118

  Fly    90 NSVPVSSIQMDIKLSR--LTVS---LKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTL 149
            .......:..:.:..|  ||.|   |..|  .:.|:.:.:.:...||.||.|||.|.|.|....
  Fly   119 TEAVAQELVYEYEAEREFLTFSKTGLTFP--EDTTWILTINYQGHLRTDNGGFYLSTYTDEEGN- 180

  Fly   150 TQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQF 214
            |::||.||||...||.||||:|:|..|..|.|.:.|...|.|:|||||..:.....      |.|
  Fly   181 TKYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAISNMPVDSSSTSGV------TVF 239

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFA---NMVVAPLLSFYEDL 276
            .::..|.:|||||::|:|   .|:..|.:..|...::|.....:.|:|   .|:|...||.|
  Fly   240 QKTVNMPSYLVAFIVSEF---VFSEGELNGLPQRVFSRNGTEHEQEWALTTGMLVEKRLSGY--- 298

  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341
            |:..:...|:|...:|||...:.|||||..:.||.|||:::.|:...|..:|...|....:.|||
  Fly   299 FDVPFALPKLDQAGIPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFG 363

  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWD-YQERHALQLYLSVLDYDAHVNTDLVTASVP 405
            :||::.||..:|||..||.......|....|||| :|..|| ..|.|.|..||..|...::..|.
  Fly   364 DLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDIFQTFHA-GSYQSALVNDASANARPMSHFVQ 427

  Fly   406 DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWD-LLQLQVDR 469
            ..|.|...|:.:...||..:.:|....:....:...|..|||......|..|..:: :.:..|:.
  Fly   428 KPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFEAIAKAAVEE 492

  Fly   470 NGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLS 534
            |..:  ...:..:|..|..|.|.||:|||||||:.:..|.|..:.....:.|    :..|:||::
  Fly   493 NYEV--KATVPDMMGSWTNQGGVPLLTVTRNYDNGSFTVKQSVYTNDKDYTN----DKLWYVPIN 551

  Fly   535 YTCPSCQHSEIISFSRWLTCPTSKPSSKSNT----VLLEKLE------AEPTDWILFNVQHTAPF 589
            |.                   .||.....||    .||.:.|      .:.|:|::.|.:.|..:
  Fly   552 YA-------------------ESKNPDFRNTEATHYLLNQSEITIYSDLDQTNWLILNKKSTGYY 597

  Fly   590 RVNYDLRNWQLLNKTL-ADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEF 653
            ||.||.:|:||:...| ..|:|   |...|||||::||:..|.||.:.:...|.:|.||..||::
  Fly   598 RVLYDAQNYQLITSALITRPHK---IDPRNRAQLINDLYRFATSGRVPHATLLELLTYLPQEDQY 659

  Fly   654 VVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTH------RPVI 712
            ..|.||......:|.....:.:|..|:.|:|.|:..||.:...:|   :.|:  |      |.|:
  Fly   660 SPWSATNTVITLLNRYLSGDADYGNFQFYVRELVSLQFDKFGVND---NKGD--HHLVPFTRNVL 719

  Fly   713 IRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFA 777
            |.|||...|..|::....: :....|:|..:....:..|.|..:|...:...|.|.:....|...
  Fly   720 INLACLAGLENCLTETTAK-LTALVEEGTKIEPNLQSQVYCNGLKQADDKTFDFVFNKLLNSTDQ 783

  Fly   778 AEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVS-NSMGYRLAKKYVSVNMQN 841
            ||:..|::||.||:|...|::.:..:.|..|:|.|........|.| ..:|..:|.:::..|.:.
  Fly   784 AERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRGEVGLLVAIEFLQKNWEK 848

  Fly   842 IRNYCSNSTDKVVNLMTPLIECLST------PKELLYFSKFFKEILRDMNGSERLIKILLERGND 900
            ....  ||....||.:...|..:|.      .|:.|      :|::..:.|||.:...|.:..:.
  Fly   849 YGQL--NSGFGGVNPLYSDIVGISAYTVNDKQKDAL------QELVDTVKGSEYVPSTLQDSVDS 905

  Fly   901 NIH----WQRTKFRPML 913
            |::    |..:...|::
  Fly   906 NVNANYAWLASNRDPLM 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	132/404 (33%)
		M1_APN_2	33..493	CDD:189008	143/469 (30%)
		ERAP1_C	579..897	CDD:288671	90/331 (27%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	132/404 (33%)
		M1_APN_2	65..514	CDD:189008	143/469 (30%)
		ERAP1_C	587..905	CDD:288671	90/334 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462084
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940