DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG32473

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	256/913 - (28%)
Similarity:	416/913 - (45%)	Gaps:	89/913 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            ||||.:.|..||:.:  |.:...:.:.|.:.|.|:.......|.::...|.:.......| |::|
  Fly   143 RLPKQIKPSKYRLHL--RPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRL-DESG 204

  Fly    90 NSVPVSSIQMDIKLSR-----LTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTL 149
              .|:..|...:..:.     .....::||:.. .||:.:.||..|.:..||.|.|:|:|.....
  Fly   205 --APLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFTGSLVDRITGMYQSSYLDKLKNR 266

  Fly   150 TQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPY--LYRALSNMPVQRTIRHASLKDYVWT 212
            ::.:.:|:|||.:||:||||||:|..:..|.|.:|.|.  .|..||||||........:.:   .
  Fly   267 SRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITE---V 328

  Fly   213 QFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLF 277
            .|.|:.||.|||.||::|.|.... |:.|.:...:..:|.|..:.:|::|....|.::::|.:.|
  Fly   329 TFAETVPMSTYLAAFVVSDFQYKE-TTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYF 392

  Fly   278 NSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGN 342
            |.:|...|:||||:|||...:.|||||..|.|.:||||...||..::|.||..||..:.:|||||
  Fly   393 NVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGN 457

  Fly   343 LVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDE 407
            ||::.||:::||...||.:|...||..:.||||...:..::....||..||.:.:..:..|:...
  Fly   458 LVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESP 522

  Fly   408 SHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGR 472
            :.|...::.|...|.|.|..||..::|||....|..||||.:...|||:.|:...::.:.
  Fly   523 AEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEE----- 582

  Fly   473 LGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI----------TPQFRNRWARNP 527
             |...::.:||:.|..|.|.|:|.|.::  ..|..::|:||..          ...|..||:
  Fly   583 -GLEFDVKQIMQTWTEQMGLPVVEVEKS--GSTYKLTQKRFLANEDDYAAEAEASSFNYRWS--- 641

  Fly   528 CWWVPLSYTCPSCQHSEIIS--FSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFR 590
               :|::||  |..:||:.|  |:.         :....|:.|    .|...||..|......:|
  Fly   642 ---IPITYT--SSINSEVQSLIFNH---------NDNEATITL----PEEASWIKINTNQVGYYR 688

  Fly   591 VNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVV 655
            |||....|..|...|  .|........:||.|::|..:||.:|.:.|.:||.::.|||.|.::|.
  Fly   689 VNYGSEQWAELISAL--KNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVP 751

  Fly   656 WVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTH--RPVIIRLAC- 717
            |.....:...:.|.......|..:.||.|.||....::|   ..|.::.::.:  |..::..||
  Fly   752 WSVGTSALATLRNRVYYTDLYTNYTTYARKLLTPIVEKV---TFTVAADHLENRLRIKVLSSACS 813

  Fly   718 ---EYELPACVSLARREFMKGTPEKGGWMTIRE-------RETVVCTAV-KFGTEGDRDMVESMY 771
               |..|...|:|..:           |:...|       |:.|....: :..||...|.|..:|
  Fly   814 LGHESSLQQAVTLFNQ-----------WLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLY 867

  Fly   772 KRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVS 836
            ...:.|.||..|:..|...:..:.|||.:.|.::.|.||:|:.......:.:|.:|..|...||.
  Fly   868 LDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVR 932

  Fly   837 VNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDN 901
            .|.:.:.:....:...:..|:..:....||..:|....:||.: ..:........:..||....|
  Fly   933 ENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAK-YPEAGAGTAARQQALEAVKAN 996

  Fly   902 IHW 904
            |.|
  Fly   997 IKW 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	130/402 (32%)
		M1_APN_2	33..493	CDD:189008	148/466 (32%)
		ERAP1_C	579..897	CDD:288671	77/331 (23%)
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	130/403 (32%)
		M1_APN_2	151..602	CDD:189008	148/466 (32%)
		ERAP1_C	677..992	CDD:288671	77/331 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462019
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850