DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG8773

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	256/926 - (27%)
Similarity:	421/926 - (45%)	Gaps:	116/926 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||..|.|..|  |:....|.....|.|...|.:..|.:|.:|||::.:|.|.   :|::.:...
  Fly   122 RLPGTLKPTHY--DLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNIS---SVSIMNTGS 181

  Fly    90 NSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLA 154
            :::.:....:|.....|...|..||....|..:.:.|...:.|...|.|||:||..:.| .:|:|
  Fly   182 DTLEILETTVDAVREFLIFQLNEPLTKGRTVRLHIGFEGSMANKIVGLYSSSYVKEDET-RKWIA 245

  Fly   155 ATQFEPNHAREAFPCFDDPIFRTPFKINLAHP--YLYRALSNMPVQRTIRHASLKDYVWTQFVES 217
            .::|||.:||:||||||:|..:..|.|.|.||  ..|.|||||.|..::...:.::   ..|.:|
  Fly   246 TSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNVDSSVSQGAFQE---VTFAKS 307

  Fly   218 HPMQTYLVAFMISKF-------DRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYED 275
            .||.|||..|::|.|       |..|...:    ..:|.:|.|:.|.:.:.|..:...::.:|.|
  Fly   308 VPMSTYLACFIVSDFAYKQVSIDTKGIGET----FSMSVYATPEQLDKVDLAVTIGKGVIEYYID 368

  Fly   276 LFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWF 340
            .|...|...|:|:.|:|||...:.|:|||..:.|.|||||...||..::|.:|..:|....:.||
  Fly   369 YFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWF 433

  Fly   341 GNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVP 405
            ||||::.||:::||...||.::...||.::.|||..:::..:....|||..|..:.:..:..:|.
  Fly   434 GNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVE 498

  Fly   406 DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRN 470
            :...|...::.|...|.:.|..||...:||..:..|:..||..|...||.:.:|:    .::|
  Fly   499 NPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFF----TEID-- 557

  Fly   471 GRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITP----------QFRNRWAR 525
             :|..|.|:|.||..|..|.|.|:||:.:..|....: :|:||...|          :|..||:
  Fly   558 -KLELGYNVTEIMLTWTVQMGLPVVTIEKVSDTEYKL-TQKRFLSNPNDYDADHEPSEFNYRWS- 619

  Fly   526 NPCWWVPLSYTCPS----------CQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWIL 580
                 :|::|...|          ...|||.     :|.|.:                  .:||.
  Fly   620 -----IPITYFTSSDSVVQRLWFYHDQSEIT-----VTVPAA------------------VEWIK 656

  Fly   581 FNVQHTAPFRVNYDLRNW-QLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGIL 644
            ||......:|||||...| .|.::.:..|:.|   ..|:||.|::|.|:||.|..:.|..|..:.
  Fly   657 FNADQVGYYRVNYDTDLWNDLADQLVVQPSAF---GSVDRAHLLNDAFALADSTQLPYATAFELT 718

  Fly   645 GYLEHEDEFVVWVATEISFERINNVAKS---NPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNM 706
            .||:.|.::|.|   .::..|:.::.::   ...|..:|.|...|:|     .|.:.||.:.|.
  Fly   719 RYLDKETDYVPW---SVAASRLTSLKRTLYYTSTYAKYKKYATALIE-----PIYTALTWTVGE- 774

  Fly   707 TH-----RPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE-------RETVVCTAVK-F 758
            .|     |...:..||...|.:|::.|..:|       ..|:...|       ||||....:: .
  Fly   775 DHLDNRLRVTALSAACSLGLESCLTEAGEQF-------NAWLAKPEDRPKADVRETVYYYGIQSV 832

  Fly   759 GTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVS 823
            |::.|.|.|..::...:.|:||..|:..|:..:..:.|||.:...:....||.|:.......:.:
  Fly   833 GSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQDYFTCLTYISA 897

  Fly   824 NSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSE 888
            |.:|..|...||..|.|.:.:....:...:.||:..:....||..:|....:||.:......|:.
  Fly   898 NPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFAKYPEAGAGTA 962

  Fly   889 RLIKILLERGNDNIHW 904
            ..:: .||...:||.|
  Fly   963 ARVR-ALETVKNNIVW 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	126/404 (31%)
		M1_APN_2	33..493	CDD:189008	144/468 (31%)
		ERAP1_C	579..897	CDD:288671	83/334 (25%)
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	126/405 (31%)
		M1_APN_2	130..579	CDD:189008	144/468 (31%)
		ERAP1_C	655..969	CDD:288671	82/333 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462026
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850