DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2111 and npepps

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	924	Identity:	236/924 - (25%)
Similarity:	384/924 - (41%)	Gaps:	116/924 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSY----RVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLS 85
            |||..:.|::|    :.|:|.      ..|.|.:...:...:.|.:||:|..|:.|     :|.|
Zfish     9 RLPTDVYPVNYGLRLKPDLVD------FTFEGKLEAAVEVTQGTNQIVMNCADIDI-----ITAS 62

  Fly    86 --DKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTT 148
              ...|..:..:......:..::|:.....|:.. :.|:::.|...|.:...|||.|.|  .::.
Zfish    63 FVPDGGEEINATGFNYQNEDEKVTLCFPSTLQKG-SGSLKIDFVGELNDKMKGFYRSKY--SSSG 124

  Fly   149 LTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQ 213
            ..::.|.||||...||.||||:|:|..:..|.|.|..|....|||||.|.....:|..:..|..:
Zfish   125 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSLVEVK 189

  Fly   214 FVESHPMQTYLVAFMISKFDRPGFTSSERSD-CPISTWARPDALSQTEFANMVVAPLLSFYEDLF 277
            |..:..|.||||||:|.::|   |..|:.|| ..:..:.......|.:||..|....|.||:|.|
Zfish   190 FATTPIMSTYLVAFVIGEYD---FVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDYF 251

  Fly   278 NSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGN 342
            :..|...||||:|:.||...:.|||||..:.|.:||.|.:.|....:|.||..|...:.:|||||
Zfish   252 SVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFGN 316

  Fly   343 LVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDE 407
            ||::.||..:||...||.::....|....||:|...:.....|...||.||..|:..:...|...
Zfish   317 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGHP 381

  Fly   408 SHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGR 472
            |.:...::.|...|.|.:..|||..:|:|.:...:..||:.:.::.|::.|.|:.|:
Zfish   382 SEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLE-------- 438

  Fly   473 LGKGLNITRIMKCWLGQPGYPLVTVTRNY--DHRTAIVSQQRFFITPQFRNRWARN----PCWWV 531
            ...|..|..:|..|..|.|:|::.|.:..  ..|...:||::|..:      ..||    |.|.|
Zfish   439 QASGKPIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCAS------GPRNDEDCPNWMV 497

  Fly   532 PLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLE-------AEPTDWILFNVQHTAPF 589
            |:|                  .|.:..||.....:||::.|       ..|..||..|......:
Zfish   498 PIS------------------ICTSEDPSCTKTKILLDQPETTVNITNVAPDHWIKINPGTVGFY 544

  Fly   590 RVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFV 654
            |:.|   :..:|...|.......|: .|:|..|.:||||||.:|.|.....|.::....:|..:.
Zfish   545 RIQY---SSAMLESLLPGIRDLTLL-PVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYT 605

  Fly   655 VWVATEISFERINNVAKSNPNYLIFKTYMRLLL--------------ERQFKRVISSDLTSSSGN 705
            ||.....:...::::......:...:.::|.|.              |.....::...:....|.
Zfish   606 VWSDLSCNLGVLSSLLSHTDFHEDIQEFIRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGK 670

  Fly   706 MTHRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESM 770
            ..|:             |.:..|||.|.:....| ..::...|..|..|.:|.|.....|.:..:
Zfish   671 AGHK-------------ATLEEARRRFREHVEGK-QILSADLRSPVYLTVLKHGDSTTLDTMLKL 721

  Fly   771 YKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVV-SNSMGYRLAKKY 834
            :|:::...||..:...|........:||||.:.. |..||.|:.......|. |:..|.:.|.|:
Zfish   722 HKQADMQEEKNRIERVLGAIPAPDLIQRVLNFAL-SEEVRPQDTVSVIGGVAGSSKQGRKAAWKF 785

  Fly   835 VSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIK-----IL 894
            |..|.:.:.|...... .:..|:...::..:..|.......||:.  .....:||.::     ||
Zfish   786 VKDNWEELHNRYQGGF-LISRLIKLTVDGFAIDKMAAEVKSFFES--HHAPAAERTVQQCCENIL 847

  Fly   895 -----LERGNDNIH 903
                 |:|..|:||
Zfish   848 LNAAWLKRDADDIH 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	124/402 (31%)
		M1_APN_2	33..493	CDD:189008	139/466 (30%)
		ERAP1_C	579..897	CDD:288671	68/342 (20%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	124/403 (31%)
		M1_APN_2	17..459	CDD:189008	139/466 (30%)
		ERAP1_C	534..845	CDD:288671	65/332 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820