Protein Alignment CG2111 and LTA4H

DIOPT Version :9

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_000886.1
• Gene: LTA4H / 4048
• HGNCID: 6710
• Length: 611
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 142/662 - (21%)
• Similarity: 234/662 - (35%)
• Gaps: 168/662 - (25%)

  Fly    52 GTVVIDLRSERSTKR-IVLNAHDLAIGKRRAVTLSDKNGNSVPVS-SIQMDIKLSRLTVSLKRPL 114
            ||..:.::|:....| :||:..||.|.|   |.:   ||..|..: ..:...|.|.:.:||...|
Human    37 GTAALTVQSQEDNLRSLVLDTKDLTIEK---VVI---NGQEVKYALGERQSYKGSPMEISLPIAL 95

  Fly   115 KVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAA------------TQFEPNHAREAF 167
            ..|....:.::|.:               ...::..|||..            :|.:..|.|...
Human    96 SKNQEIVIEISFET---------------SPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAIL 145

  Fly   168 PCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHA--------SLKDYVWTQFVESHPMQTYL 224
            ||.|.|..:..:...::.|....||.:     .||..        |.|.|   :|::..|:..||
Human   146 PCQDTPSVKLTYTAEVSVPKELVALMS-----AIRDGETPDPEDPSRKIY---KFIQKVPIPCYL 202

  Fly   225 VAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLV 289
            :|.::      |...|.:.......|:..:.:.::.:.......:|...||| ...|...:.||:
Human   203 IALVV------GALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDL-GGPYVWGQYDLL 260

  Fly   290 AL-PDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIW 353
            .| |.|.:...||..|.......|..|...|::         :|..:.:.|.||||:...|...|
Human   261 VLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNV---------IAHEISHSWTGNLVTNKTWDHFW 316

  Fly   354 LKNVFALYLSRFGVHSLRPEWDYQERHAL----QLYLSVLDY-DAHVNTDLV---TASVPDESHI 410
            |.....:||.|.....|..| .::..:||    :|..||..: :.|..|.||   |...||
Human   317 LNEGHTVYLERHICGRLFGE-KFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPD---- 376

  Fly   411 WAAYNEIG-ERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQL--------- 465
             .||:.:. |:..|:||.:...:.|.|.:|..|:.|:..::.::.|:.|:.|.|..
Human   377 -VAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVL 440

  Fly   466 -QVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCW 529
             |||.|              .||..||.|  .:..|||
Human   441 NQVDWN--------------AWLYSPGLP--PIKPNYD--------------------------- 462

  Fly   530 WVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNY- 593
             :.|:..|       |....||:|......:| .|...|:.|.:...:..|......||..:.:
Human   463 -MTLTNAC-------IALSQRWITAKEDDLNS-FNATDLKDLSSHQLNEFLAQTLQRAPLPLGHI 518

  Fly   594 ----DLRNWQLLNKTL----------------ADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYD 638
                ::.|:..:|.:.                |.|...::.....|.:....||....:.|..:|
Human   519 KRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHD 583

  Fly   639 MALGILGYLEHE 650
            .|  :..|.||:
Human   584 QA--VRTYQEHK 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	92/400 (23%)
		M1_APN_2	33..493	CDD:189008	112/482 (23%)
		ERAP1_C	579..897	CDD:288671	16/93 (17%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	142/662 (21%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	267..272		0/4 (0%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641	362..365		0/2 (0%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	564..566		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810