DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and LNPEP

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	931	Identity:	253/931 - (27%)
Similarity:	419/931 - (45%)	Gaps:	119/931 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNA--HDLAIGKRRAVTLSDK 87
            |||..:|||.|.:.:  ..|.....|.|:|.|.:::.:.|..|:|::  |:::    |...:|
Human   167 RLPTAVVPLRYELSL--HPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNIS----RVTFMS-- 223

  Fly    88 NGNSVPVSSIQMDIKL------SRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHN 146
                 .|||.:...::      .::.:.....|.....|::::.:::.:.:...|||..:|.|.:
Human   224 -----AVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDES 283

  Fly   147 TTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKD-YV 210
            .. .::.|||||||..||.||||||:|.|:..|.|.:.....|.||||||.:.::   .|.| .|
Human   284 NE-KKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSV---VLDDGLV 344

  Fly   211 WTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYED 275
            ..:|.||..|.||||||::.:...   .|.:.:...:|.:|.|:.:.|..:|......||.|:::
Human   345 QDEFSESVKMSTYLVAFIVGEMKN---LSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQN 406

  Fly   276 LFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWF 340
            .|...|..||:||||:|||...:.|||||..|.||:|||||..||:.|::.|.:.:|..:.:|||
Human   407 YFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWF 471

  Fly   341 GNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVP 405
            ||||::.||:::||...||.::..|.:..:..|....| ..|......:..|:..::..:::||.
Human   472 GNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE-DFLDARFKTMKKDSLNSSHPISSSVQ 535

  Fly   406 DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRN 470
            ....|...::.:...|.:.|..||...:.|:.:..|:..||..::..:..|.|.||..      |
Human   536 SSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSF------N 594

  Fly   471 GRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFIT--PQFRNRWARNP-----C 528
            ....:.|::.|:||.|..|.|:|||||.:.  .:...:.|:|||:.  |:.:      |     .
Human   595 EVTNQTLDVKRMMKTWTLQKGFPLVTVQKK--GKELFIQQERFFLNMKPEIQ------PSDTSYL 651

  Fly   529 WWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNY 593
            |.:||||......:|:..|        .|....||..:.|    .|...|:..|:.....:.|:|
Human   652 WHIPLSYVTEGRNYSKYQS--------VSLLDKKSGVINL----TEEVLWVKVNINMNGYYIVHY 704

  Fly   594 DLRNWQ-LLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWV 657
            ...:|: |:::...:|   .::...:||.|::::|.||..|.:....|..::.||.:|:...  .
Human   705 ADDDWEALIHQLKINP---YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTA--P 764

  Fly   658 ATEISFER--INNVAKSNPNYLIFKTYMRL---LLERQFKRV---ISSDLTSSSGNMTHRPV--- 711
            .||..|:.  |.|:.:.       ..||.|   |:.|.||.:   |.....:..|..:.|.:
Human   765 ITEALFQTDLIYNLLEK-------LGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA 822

  Fly   712 IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERET----VVCTAVKFGTEGDR--DMVESM 770
            ::..||.:.|..|.:.|.:.|       ..||.....::    |:.|..|.|.:.|:  ..:...
Human   823 LLEFACTHNLGNCSTTAMKLF-------DDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGK 880

  Fly   771 YKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESS----GVRKQNARRTFKAVVSNSMGYRLA 831
            |......|||..:|.|||.|.:|    |.|.|..:||    ..|.|......:.|..:..|:.||
Human   881 YISIGSEAEKNKILEALASSEDV----RKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLA 941

  Fly   832 KKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSE-----RLI 891
            ..:|..|...:.......:..:.|::.......||...|.....||:      |.||     |.:
Human   942 WDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFE------NQSEATFRLRCV 1000

  Fly   892 KILLERGNDNIHWQRTKFRPM 912
            :..||....||.|.....:.:
Human  1001 QEALEVIQLNIQWMEKNLKSL 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	126/404 (31%)
		M1_APN_2	33..493	CDD:189008	141/468 (30%)
		ERAP1_C	579..897	CDD:288671	79/344 (23%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101
		M1_APN_2	175..617	CDD:189008	141/468 (30%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	689..1009	CDD:314669	81/348 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850