DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and erap1b

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	970	Identity:	261/970 - (26%)
Similarity:	432/970 - (44%)	Gaps:	131/970 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKN- 88
            |||..:.||.|  :::...|.....|.|:|.|.:...:.||.|:|::.:|.|...|   |.|.|
Zfish    46 RLPDTISPLHY--NLLIHPNLTSLDFTGSVQIQIEVLQDTKTIILHSKNLQISSAR---LLDANI 105

  Fly    89 GNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWL 153
            ....|:..::.........||.|..||....||:.:.|.:.|.....|||.|.|......: :.:
Zfish   106 AQQQPLKVLEYPYFQQIALVSDKALLKRGHVYSVELHFAANLSESFHGFYKSTYRTSKGDV-RVV 169

  Fly   154 AATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVW-TQFVES 217
            |:||||...||.||||||:|.|:..|.:.:.....:.||||||..||:   .||:.:: .||..|
Zfish   170 ASTQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMPKLRTL---ELKNGLFEDQFDVS 231

  Fly   218 HPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNSTY- 281
            ..|.|||||:::|.|  ...:.:.:....||.:|.|:.:.|.|||......||.||:|.|:..|
Zfish   232 VKMSTYLVAYIVSDF--LSISKTSQHGVQISVYAVPEKIDQAEFALDAAVKLLDFYDDYFDIPYP 294

  Fly   282 --RQKK-----------------IDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGV 327
              :|:|                 :||.|:|||...:.|||||..:.|.:||:|..:||..|:.|:
Zfish   295 LPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLFDPHKSSASDKLGI 359

  Fly   328 ARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYD 392
            ...:|..:.:|||||||::.||:::||...||.::....|:...||...:: :.|......::.|
Zfish   360 TMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQVED-YFLGKCFEAMEVD 423

  Fly   393 AHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSS 457
            :..::..|:..|.:.:.|...::::...|.|.:..||...:..:.:...:.:||..|:.:...:|
Zfish   424 SLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKYLKHYSYQNTVNS 488

  Fly   458 DFWDLLQLQVDRN----GRLGKG---------------------LNITRIMKCWLGQPGYPLVTV 497
            :.|:.|....|.:    ||| ||                     |::..:|:.|..|.|:||:|:
Zfish   489 NLWESLTNVCDSDGLDEGRL-KGDESCRHSASNTGASKWHSEDELDVKAMMETWTLQEGFPLITI 552

  Fly   498 TRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSK 562
            .  ...|...:||:|:..:.....  ..:..|.|||:|..     |:..:..|:|.      .:|
Zfish   553 A--VKGREVRLSQERYLKSDDLSQ--TSSFLWQVPLTYIT-----SDSTTVHRFLL------KTK 602

  Fly   563 SNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLL------NKTLADPNKFRLIHRVNRAQ 621
            ::.:.|    .|..|||.|||..:..:.|:|:...|..|      |.|....|        :||.
Zfish   603 TDVLYL----PEEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSN--------DRAS 655

  Fly   622 LVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLL 686
            |:::.|.|...|.:..|.||.:..||..|.|  :...|:...|.:       |.|.:.:....:.
Zfish   656 LINNAFQLVSVGKLPLDKALDLTLYLSKETE--IMPVTQGFNELV-------PLYKLMEKRDMVE 711

  Fly   687 LERQ--------FKRVISSDLTSSSGNMTHRPV---IIRLACEYELPACVSLARREFMKGTPEKG 740
            ||.|        |:::|...|.:..|:::.|.:   ::...|....|.|||.|.:.|.......|
Zfish   712 LENQMKGYILQLFQKLIEQQLWTDEGSVSERMLRSYLLLFGCVRGHPPCVSNATQLFNLWRDSDG 776

  Fly   741 GWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFE 805
            . |::....|:...:|...||...|.:...||.|.:.:.|..:..||..|    .|...|.|..|
Zfish   777 N-MSLPNDVTMAVFSVGARTEDGWDFLFEKYKESMYVSMKSRIKQALMTS----PLDHKLKWMME 836

  Fly   806 SS--G--VRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLST 866
            .|  |  ::.|:......:|..|...|:.|..::..|..::.......:..:.:::..:....||
Zfish   837 QSLEGELIKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSIAHMVVGVTNQYST 901

  Fly   867 PKELLYFSKFFKEILRDMNGSE-RLIKILLERGNDNIHWQRTKFRPMLQAIRDIILWRSR 925
             :|:|...:.|..:|:...|:| |.|:..:|...:||.|. .|..|:|:|      |..|
Zfish   902 -REMLAEVRNFFSLLQPETGAELRCIQQAVENIEENIRWM-DKNLPLLKA------WLHR 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	131/417 (31%)
		M1_APN_2	33..493	CDD:189008	148/506 (29%)
		ERAP1_C	579..897	CDD:288671	79/339 (23%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	131/418 (31%)
		M1_APN_2	54..548	CDD:189008	148/506 (29%)
		ERAP1_C	615..932	CDD:288671	79/339 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850