DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG31445

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	307/920 - (33%)
Similarity:	503/920 - (54%)	Gaps:	50/920 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQ-PFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKN 88
            |||..|.|..|.:.|:|.:..|.. .|.|.|.|.:::.::|:.|.|::.:|.|.:.| :||...:
  Fly    28 RLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESR-ITLRQIS 91

  Fly    89 GNSVPVSSIQMDIKLSRLTV----------SLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYV 143
            |..      .||..:|..:|          :.|..|..|| |.:.:.|::.|.....|:|.|:|.
  Fly    92 GAG------NMDNCVSSTSVNPTHDYYIFHTCKELLAGNV-YKLFLPFSADLTPQLFGYYRSSYK 149

  Fly   144 DHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKD 208
            |..|..|:||:||||||:.||:||||||:|.|:..|.:.|.:...:.|||||||:....|.||.:
  Fly   150 DPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVREIRPHESLAN 214

  Fly   209 YVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCP----ISTWARPDALSQTEFANMVVAPL 269
            |:|.:|.||.||.|||||:.::.|      |.:.|..|    ..|||||:|:.|.::|......:
  Fly   215 YIWCEFQESVPMSTYLVAYSVNDF------SFKPSTLPNGALFRTWARPNAIDQCDYAAEFGPKV 273

  Fly   270 LSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMM 334
            |.:||:.|...|...|||.:|:|||:..:.|||||..:.|.:|||....||:.|:|.:|..:|..
  Fly   274 LQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSLADKQDLANVIAHE 338

  Fly   335 VVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDL 399
            :.:|||||||::.||.::||...||.|::..||..:.|||..:::.:|...::....|:.|::..
  Fly   339 LAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALMTAFRLDSLVSSHP 403

  Fly   400 VTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQ 464
            ::..:...:.|..:::.|..:|.:.:..|:|..||||::.|.||.||.:||.:.|..::.|:.|.
  Fly   404 ISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAYKNAEQNNLWESLT 468

  Fly   465 LQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCW 529
            ....:||.|....:|..||..|..|.|:|::.:||:|...||.::|:|:....|.... .|..||
  Fly   469 TAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRNSQIPQA-DRVGCW 532

  Fly   530 WVPLSYTCPSCQHSEIISFSRWLTCPTSK---PSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRV 591
            |||||||..........|...|:.|.::.   |::..::       |.|.:|::.|:|.:.|::.
  Fly   533 WVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHS-------AGPEEWLILNIQLSTPYKA 590

  Fly   592 NYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVW 656
            |||.|||:||..|| :...|:.||.:|||||:||:...||:|:.:|:.||.:..||..|.:.:.|
  Fly   591 NYDARNWKLLIDTL-NSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERDLIPW 654

  Fly   657 VATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSD----LTSSSGNMTHRPVIIRLAC 717
            .:...:.:.:|.:.:..||:..||.||:.||...::.:...:    |.:....:..:..::.:||
  Fly   655 KSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVVNVAC 719

  Fly   718 EYELPACVSLARREFMK----GTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFAA 778
            :|::..||:.|:..|.:    ..|::...:.:..|.||.|||:..|||.|.:.:.|.|::||.|:
  Fly   720 QYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVAS 784

  Fly   779 EKESLLTALACSRNVFALQRVLIWTFE-SSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNI 842
            |::::|:.|.||:.|:.|||.:..:|. .|.:|||::...|:||.|..:|:.|||:|...|::.|
  Fly   785 ERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELI 849

  Fly   843 RNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHWQRT 907
            ..|....|..:..|:|||.|.:||..:|..|..|..:....:.|..:.::..||....|:.|...
  Fly   850 HKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQWMDW 914

  Fly   908 KFRPMLQAIR 917
            .:....:.||
  Fly   915 NYHKFSRTIR 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	145/410 (35%)
		M1_APN_2	33..493	CDD:189008	166/474 (35%)
		ERAP1_C	579..897	CDD:288671	105/326 (32%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	145/411 (35%)
		M1_APN_2	43..497	CDD:189008	164/467 (35%)
		ERAP1_C	578..904	CDD:288671	105/326 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449991
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850