DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG31343

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	977	Identity:	246/977 - (25%)
Similarity:	432/977 - (44%)	Gaps:	122/977 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALFFHLEANKTAVG--RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHD 73
            |||.....:..:.|  |||....|.||.|::.|.::.....|.|||.||:|....|..|.|:...
  Fly    41 ALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQ 105

  Fly    74 LAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKV------------NVTYSMRVAF 126
            .:..:...::.......::|::          :|..|:|...|            |..:::.:.:
  Fly   106 TSNFEATIISRDVATPTAIPLT----------VTPELQREFLVLTQTTAGEAFGANTNWTITINY 160

  Fly   127 TSVLRNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRA 191
            |.:.|:|..|||.|:|.|.:.. ..:||.||||..:||.||||:|:|..|..|.|.:.|...|.|
  Fly   161 TGIHRSDMGGFYISSYTDDDGE-QHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTA 224

  Fly   192 LSNMPVQRTIRHASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDAL 256
            :|||||......:.:     |.|..:..|.||||||::|.|:.   |:.|.:......::|....
  Fly   225 ISNMPVNTAATSSGV-----TAFQTTPKMSTYLVAFIVSDFES---TTGELNGIRQRVFSRKGKQ 281

  Fly   257 SQTEFA---NMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQR 318
            .|.|:|   .::|...|:.|   |...:...|:|...:|||:..:.|||||..:.|:.:.::.|.
  Fly   282 DQQEWALWSGLLVESSLASY---FGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQN 343

  Fly   319 SSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWD-YQERHAL 382
            |:|:.:..:|..:.....:.|||:|||:.||..:|||..||...|........|.|| ||..|
  Fly   344 STINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFH-- 406

  Fly   383 QLYLSVLDYDAHVNTDLVTASVP------DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTA 441
                 |.||::.:..|.:.::||      ..|.|...||.....|.|.:..|......::.:.|.
  Fly   407 -----VNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTG 466

  Fly   442 LRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGL--NITRIMKCWLGQPGYPLVTVTRNYDHR 504
            |.:||   .....||.|.|||.....:....||..|  ::..|...|..|.||||:||||||:..
  Fly   467 LNKYL---TKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAG 528

  Fly   505 TAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLE 569
            |..::|:|:.......|    :..|:|||::...:.......|.:.:|...|.        .::.
  Fly   529 TITITQKRYVANKTDTN----SATWYVPLNFATANKYDYRDTSATHYLLNVTE--------TVIS 581

  Fly   570 KLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTL-ADPNKFRLIHRVNRAQLVDDLFSLAWSG 633
            .:||...|||:.|:|::..:|..||.:|:.|:...| :.|.:|   |..|||||:.|.:....:.
  Fly   582 DVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRF---HPRNRAQLLYDTYIFVSTD 643

  Fly   634 DIEYDMALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSD 698
            .:.:.:.|.:||||.:|.::..|..........:...:.:.:|..|:.:::.|::..|.::..::
  Fly   644 RLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNE 708

  Fly   699 LTSSSG-NMTHRPVIIRLACEYELPACVSLARREFMK----GTPEKGGWMTIRERETVVCTAVKF 758
            :..... |...|.|::.|||:.....|.:.:..:..:    ||..:.   |::.:  ..|..::.
  Fly   709 IPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTAIEA---TLKTQ--AYCAGLRS 768

  Fly   759 GTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTF--KAV 821
            .|......|:|....|:.:.::...:::|.||.:...|...|..:.:::.....:.|.:.  .|.
  Fly   769 TTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAY 833

  Fly   822 VSNSMGYRLAKKYVSVN-----------------MQNIRNYCSNSTDKV-VNLMTPLIEC----- 863
            ..:.:|...:.:::..|                 ::.|..|..:...|. :|.:..::|.
  Fly   834 SRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSY 898

  Fly   864 ----LSTPKELLYFSKF-FKEILRD--MNGSERLIKILLERGNDNIHWQRTKFRPMLQAIRDIIL 921
                |||..:....|.| :.|:.||  :|..|..:|   |.|:.::   .:....:|.:...::|
  Fly   899 INDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLK---ENGSPSL---TSSITTILVSAMALLL 957

  Fly   922 WR 923
            :|
  Fly   958 FR 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	124/417 (30%)
		M1_APN_2	33..493	CDD:189008	140/483 (29%)
		ERAP1_C	579..897	CDD:288671	69/355 (19%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	124/417 (30%)
		M1_APN_2	65..517	CDD:189008	140/483 (29%)
		ERAP1_C	591..886	CDD:288671	56/302 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462082
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850