DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG9806

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	312/933 - (33%)
Similarity:	495/933 - (53%)	Gaps:	56/933 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YLTILTALFFHLEANKTAVGRLPKWLVPLSYRVDIVTRINQPYQ---PFGGTVVIDLRSERSTKR 66
            ||.:|     ||.......|.....|.||.|.:.::|.: :|.:   .|.|.|:|.||..|.|:.
  Fly     7 YLIVL-----HLCLPIGGTGATASNLRPLHYNLSLLTEV-EPLKLSGNFSGEVIIRLRVWRETRT 65

  Fly    67 IVLNAHDLAIGKRRAVTLSDKN-GNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVL 130
            |:|:.:.|.:|:.  |.|..:| |..|.|..:.....:.:|.:.....|.:...|::.|.|:..|
  Fly    66 IILSNNGLQVGEN--VLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQL 128

  Fly   131 RNDNTGFYSSNYVD--HNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALS 193
             :..:|::...|:|  |:   .||:|.||..||.|...||||::..|..||.:|||||....|:|
  Fly   129 -SRASGYFVGGYMDSKHH---PQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVS 189

  Fly   194 NMPVQRTIRHASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCP-ISTWARPDALS 257
            ||.|.:|..|.. .|||||.|.::..|....:||.|::|...  ||:|....| ::||.||....
  Fly   190 NMRVLKTSDHEK-DDYVWTTFQQTPAMSVQKLAFSINRFTNR--TSAEIPKGPALTTWLRPKIAD 251

  Fly   258 QTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSID 322
            |.::|..:...::.|:..||...|...|||.:.|||..::|.|:.||.::.|.:.||.:|||:..
  Fly   252 QGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTR 316

  Fly   323 DQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLS 387
            .:|.||..||....:.|..:|.:.|.:   ||.|..:.|:|.|.|.::.|.|.:.|...::..|:
  Fly   317 AKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALA 378

  Fly   388 VLDYDAHVNT---DLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVY 449
            ||..|:..:.   .|..||...::.        ..:|:|:||.|||.::|.:|:|.|||.||...
  Fly   379 VLVEDSKSSAYPMSLAYASKSSDTQ--------ANQKSALLFRMLHSLIGTQAFLNALRLYLQRS 435

  Fly   450 ANRTATSSDF-WDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRF 513
            ...::::..| |..||.:.|....|.:.:.::::|..|..||||||:.|.||||.....|:|:||
  Fly   436 HKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERF 500

  Fly   514 FITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISF-----SRWLTCPTSKPSSKSNTVLLEKLEA 573
            ...|. :....|..||||||::..     :.|.||     |.||||...:.:|   .::|.:: |
  Fly   501 LRNPG-KLMQKRQQCWWVPLTFAT-----AGIDSFVSTLPSEWLTCQGRQTAS---PLILNEV-A 555

  Fly   574 EPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYD 638
            :|..|::||::...|.|:.||.|||||:...|:..|. ..|.|..||||:.|:.:||.:|.:.||
  Fly   556 QPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNA-SSIDRFTRAQLISDVLNLAGAGVVTYD 619

  Fly   639 MALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSD-LTSS 702
            :||..||:|.:||||:||.|.:...|.::...:.......||.:||.||:.:|..:...| ..:.
  Fly   620 LALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAE 684

  Fly   703 SGNMTHRPVII-RLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDM 766
            :.|:|...||: :|:|..:|.:|...|.:||...|.|... :.:...||:.|||::||||.|..:
  Fly   685 NANITELMVIVLQLSCRTDLESCADFALKEFAGLTLETNR-IPVDLSETIYCTAIQFGTEADWTL 748

  Fly   767 VESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLA 831
            :..:|.|||.:.|:..||:|:||||..:||.::|...|....:.|.:....|.||..|.:||.:|
  Fly   749 LRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIA 813

  Fly   832 KKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLE 896
            |||:..|::.|.....::||::..|:|.|::.::|.:||.....|.:..|:::.|.|...:.:||
  Fly   814 KKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILE 878

  Fly   897 RGNDNIHWQRTKFRPMLQAIRDI 919
            .|.|||.|...::..:|.|:.:|
  Fly   879 LGEDNISWHNRQYHNLLAAVCNI 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	127/405 (31%)
		M1_APN_2	33..493	CDD:189008	151/470 (32%)
		ERAP1_C	579..897	CDD:288671	111/319 (35%)
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	110/318 (35%)
		Peptidase_M1	25..392	CDD:279741	124/379 (33%)
		GluZincin	30..480	CDD:301352	151/470 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449973
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850