DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and CG31198

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	243/948 - (25%)
Similarity:	419/948 - (44%)	Gaps:	129/948 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQ---------PFGGTVVIDLRSERSTKRIVLNAHDLAIGKR- 79
            ||.:.:.|::|.:.:     :||.         .|.|.|.|::.|.::|..|.|::.:|....|
  Fly    42 RLAEHITPVNYNITL-----RPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVRE 101

  Fly    80 --RAVTLSDKNGNSVPVS---SIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYS 139
              :..|....|...:.:|   :...|..:.:||.|  ..|..|.||.:...:|.::.:|..|||.
  Fly   102 YWQKPTTEVANPTVIQISATNTTNYDTDIVKLTAS--TALTANTTYILHFVYTGLMEDDMHGFYR 164

  Fly   140 SNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTI-RH 203
            |:|||.| .:|:||.:|||:.:|||.|||.||:|.|:..|.:.|.....:.::||   .|.| .:
  Fly   165 SSYVDDN-NVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSN---TRLISSY 225

  Fly   204 ASLKDYVWTQFVESHP-MQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVA 267
            .|.::.:::...::.| |.|||:||:||:|       ..|.|.....:|||:..:||::...|..
  Fly   226 PSTEEGIFSDVYKTTPKMSTYLLAFIISEF-------VARKDDDFGVYARPEYYAQTQYPYNVGI 283

  Fly   268 PLLSFYEDLFNSTY---RQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVAR 329
            .:|.......:..|   ...|:|:.|:|||:..:.|||||..:.|.|||.|...:::..:|.:|.
  Fly   284 QILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAA 348

  Fly   330 AVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDA- 393
            .||....:.|||:||:..||...||...||.|...||...:..:|:.:::..:....||:..|:
  Fly   349 VVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDST 413

  Fly   394 HVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSD 458
            :....|...:....:|:...:|.|...|.|....|:...|||:.:..:|:.||..|..:::....
  Fly   414 NATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEY 478

  Fly   459 FWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRW 523
            .....|.....:.......:   |.|.:..|.||||:.||  ..:.....:|:||.:.....:..
  Fly   479 LLGAWQANWPNSSYNESSKD---IFKSFTEQVGYPLINVT--VGNSQVSFTQKRFLLKESDGSDS 538

  Fly   524 ARNPCWWVPLSYTCPSCQHSEIISF----SRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQ 584
            :..  :.||:|||.     ||..:|    .:::..|....:.:.|:.:         .||:.|:|
  Fly   539 SLK--YTVPISYTT-----SETNNFLNTTPKFILKPNVTTTVQFNSTI---------KWIVVNIQ 587

  Fly   585 HTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEH 649
            .|..:||.|...||..::..|...| :..||..||||:|||||:||.:|.:.|::.|.::.||:.
  Fly   588 QTGYYRVTYSDDNWHAIHHALITAN-WGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQT 651

  Fly   650 EDEFVVWVATEISFERINNVAKSNPNYLI---------FKTYMRLLLERQFKRVISSDLTSSSG- 704
            |..::.|.:....|           |||.         |..|::.|..:.:.::..::.::.:.
  Fly   652 ETNYIPWTSAFNGF-----------NYLTIRLGNDTADFNYYIQTLTNKAYNQLGFNEASNDTAL 705

  Fly   705 NMTHRPVIIRLACEYELPACVSLARREFMK-GTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVE 768
            ::..|..|:..||.|....|:|.|:..|.. .|..|      ..|.||.|..::.|.|.:...:.
  Fly   706 DIYLRTKILSWACRYGSSDCISQAQGYFQSLATVPK------NIRATVYCVGLREGGEAEFQALY 764

  Fly   769 SMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFE---SSGVRKQNARRTFKAVVSNSMGYRL 830
            :.:|....|.|:..|..:..|.:....:::|    |:   |..:|:|:     |:.|       |
  Fly   765 NKFKNETVATEETLLQNSFGCVKTQSLIEKV----FDLIISDEIRRQD-----KSSV-------L 813

  Fly   831 AKKYVSVNMQNIRNYCSNSTDK-------------VVNLMTPLIECLSTPKELLYFSKFFKEILR 882
            |..|.. |.:|:....:..|.|             |..:::.:....:|.::|.....|.|....
  Fly   814 ATLYTE-NNENVSPVFALVTQKYEELAEAMGGYSAVATVISNIAARFTTNQQLTDLENFNKANGA 877

  Fly   883 DMNGSERLIKILLERGNDNIHWQRTK---FRPMLQAIR 917
            ....|:..:........:|:.|...|   ||..|...|
  Fly   878 KFGSSQATLTAAEATVKENLEWATAKLGVFRSYLANYR 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	122/416 (29%)
		M1_APN_2	33..493	CDD:189008	134/480 (28%)
		ERAP1_C	579..897	CDD:288671	80/344 (23%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	122/417 (29%)
		M1_APN_2	50..510	CDD:189008	134/480 (28%)
		ERAP1_C	582..898	CDD:288671	81/350 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920