DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and TRHDE

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	938	Identity:	270/938 - (28%)
Similarity:	434/938 - (46%)	Gaps:	88/938 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLS-DKN 88
            ||...|.||.|.: ::|...:.: .|.|.|.:::....:|:.:||:|..:|:.|   |.|: |:.
Human   185 RLSGHLKPLHYNL-MLTAFMENF-TFSGEVNVEIACRNATRYVVLHASRVAVEK---VQLAEDRA 244

  Fly    89 GNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWL 153
            ..:|||:...:..:...|.|.|.|.|.....|::::.:.:::.|:..||:.|:||.|..  .::|
Human   245 FGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGE--RRFL 307

  Fly   154 AATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFVESH 218
            ..|||.|.|||:||||||:||::..|||::.|...|.:||||||:.::....  .:|...|.::.
Human   308 GVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEED--GWVTDHFSQTP 370

  Fly   219 PMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDAL--SQTEFANMVVAPLLSFYEDLFNSTY 281
            .|.||.:|:.|..|.....|:  :|...:..:|||||:  ...::|..:...|:.||||.|...|
Human   371 LMSTYYLAWAICNFTYRETTT--KSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPY 433

  Fly   282 RQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSV 346
            ...|:||:|:|...:.:.|||||..|.|:.:|.|...|||.....|...:...:.:||||:||:.
Human   434 SLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTP 498

  Fly   347 AWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQ------LYLSVLDYDAHVNTDLVTASVP 405
            .||.::|||..||.|....|...|.|.|:.:::..|.      :.|..|.....|:.:::.|:..
Human   499 VWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDI 563

  Fly   406 DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRN 470
            |....|.||     :|.|.|..||...||...:...|:.||.::....|..:|.|:.|...:.||
Human   564 DRVFDWIAY-----KKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRN 623

  Fly   471 GRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI--------TPQFRNRWARNP 527
               ||.:||..:|..|..|.|||::|:..|......|:..|:.||        ..:.:|   .:.
Human   624 ---GKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQN---NSY 682

  Fly   528 CWWVPLSYTCPSCQH--SEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFR 590
            .|.:||:....:..|  ||.|.   |:    |..|.......|:|     ..|:|.|:..|..||
Human   683 LWQIPLTIVVGNRSHVSSEAII---WV----SNKSEHHRITYLDK-----GSWLLGNINQTGYFR 735

  Fly   591 VNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVV 655
            ||||||||:||...|.  ....::...|||.|:||.||||.:|.:..::.|.|:.||..|.:|:.
Human   736 VNYDLRNWRLLIDQLI--RNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLP 798

  Fly   656 WVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDL------TSSSGNMTH------ 708
            |.|...:...::.:.....||.||..|:       .|:|.::.:      .:.:|::..
Human   799 WHAASRALYPLDKLLDRMENYNIFNEYI-------LKQVATTYIKLGWPKNNFNGSLVQASYQHE 856

  Fly   709 --RPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMY 771
              |..:|.|||.:....|...|..............:.:..|:.|.||.|....|...:.:...:
Human   857 ELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKF 921

  Fly   772 KRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVS 836
            ..:...:||:.||.||.||.:...|.|:|..:..|..|..|:|......|..|..|..||.|:..
Human   922 HSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFR 986

  Fly   837 VNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNG-SERLIKILLERGND 900
            ...:.:......:......|::.:.|.|:|..||    |..|..:::.:| :.......:|....
Human   987 DKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL----KELKNFMKNYDGVAAASFSRAVETVEA 1047

  Fly   901 NIHWQRTKFRPMLQAIRDIILWRSRAKR 928
            |:.|:      ||.. .::..|..:|.|
Human  1048 NVRWK------MLYQ-DELFQWLGKALR 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	130/404 (32%)
		M1_APN_2	33..493	CDD:189008	150/468 (32%)
		ERAP1_C	579..897	CDD:288671	86/332 (26%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	148/463 (32%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	88/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155375
Domainoid	1	1.000	108	1.000	Domainoid score	I6427
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850