Protein Alignment CG2111 and ANPEP

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 958
• Identity: 257/958 - (26%)
• Similarity: 418/958 - (43%)
• Gaps: 140/958 - (14%)

  Fly    25 RLPKWLVPLSYRVDIVTRINQPY--------QPFGGTVVIDLRSERSTKRIVLNAHDL--AIGKR 79
            |||..|.|.||||.:     :||        ..|.|:..:....:.:|..|::::..|  .:.:.
Human    75 RLPNTLKPDSYRVTL-----RPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQG 134

  Fly    80 RAVTLSDKNGNSVP-VSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYV 143
            ..|.|....|:..| :...::......|.|.||..|..:..|.|...|...|.:|..|||.|.|:
Human   135 HRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYM 199

  Fly   144 DHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNM-------PVQRTI 201
            :.|  :.:.:|.||.:...||::|||||:|..:..|.|.|.||....|||||       |:.
Human   200 EGN--VRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLP--- 259

  Fly   202 RHASLKDYVW--TQFVESHPMQTYLVAFMISKFDRPGFTSSERSD-CPISTWARPDALS--QTEF 261
                 :|..|  |:|..:..|.|||:||::|:||   :...:.|: ..|..||||.|::  ..::
Human   260 -----EDPNWNVTEFHTTPKMSTYLLAFIVSEFD---YVEKQASNGVLIRIWARPSAIAAGHGDY 316

  Fly   262 ANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQG 326
            |..|..|:|:|:...:::.|...|.|.:.||||...:.|||||..:.|.|||:|...||..:::.
Human   317 ALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKER 381

  Fly   327 VARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDY 391
            |...:|..:.:|||||||::.||:::||...||.|:...|.....|.|:.::...|.....|:..
Human   382 VVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAV 446

  Fly   392 DAHVNTDLVT---ASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRT 453
            ||..::..::   :.:...:.|...::.|...|.|.:..||...:.|:.:...|..||..:|.:.
Human   447 DALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQN 511

  Fly   454 ATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITP- 517
            ....:.||.||..|: |..:.....:..||..|..|.|:|::||    |..|..:||:.|.:.|
Human   512 TIYLNLWDHLQEAVN-NRSIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFLLDPD 571

  Fly   518 -------QFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKP---SSKSNTVLLEKLE 572
                   :|      |..|.||::......|..:.     ||....::.   |:..|
Human   572 SNVTRPSEF------NYVWIVPITSIRDGRQQQDY-----WLIDVRAQNDLFSTSGN-------- 617

  Fly   573 AEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEY 637
                :|:|.|:..|..:|||||..||:.:...|...:.  .|..:||||:::|.|:||.:..:..
Human   618 ----EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHS--AIPVINRAQIINDAFNLASAHKVPV 676

  Fly   638 DMALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQ-----FKRVISS 697
            .:||....:|..|.:::.|.|...|.                 :|.:|:.:|.     .|..:..
Human   677 TLALNNTLFLIEERQYMPWEAALSSL-----------------SYFKLMFDRSEVYGPMKNYLKK 724

  Fly   698 DLT-------SSSGNMTHRPV----------IIRLACEYELPACVSLARREFMKGTPEKGGWMTI 745
            .:|       :::.|....|.          .|..||...:|.|..:....|.:       ||..
Human   725 QVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQ-------WMEN 782

  Fly   746 RE--------RETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIW 802
            ..        |.||.|.|:..|.|.:.|.....::.:....|.:.|..|||||:.::.|.|.|.:
Human   783 PNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSY 847

  Fly   803 TFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTP 867
            |.....:|||:|..|..::.:|.:|..|...:|..|.:.:.|.....:....||:..:....||.
Human   848 TLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTE 912

  Fly   868 KELLYFSKFFKEILRDMNGS-ERLIKILLERGNDNIHWQRTKFRPMLQ 914
            .||....:|.|:......|| .|.::..||:...||.|.:.....:||
Human   913 YELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	139/479 (29%)
		ERAP1_C	578..897	CDD:463368	85/349 (24%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62
		Metalloprotease	69..967		257/958 (27%)
		M1_APN-Q_like	84..545	CDD:341064	140/479 (29%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		1/9 (11%)
		ERAP1_C	619..946	CDD:463368	86/352 (24%)