DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and ape2

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	864	Identity:	200/864 - (23%)
Similarity:	367/864 - (42%)	Gaps:	126/864 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGN 90
            |||.:.|:.|.:.:...:..  ..:||.||:.|.....:..|.|:..:|     |.:|.:.:.|
pombe    20 LPKNVKPIHYDLSLYPDLET--FTYGGKVVVTLDVLEDSNSITLHGINL-----RILTAALEWG- 76

  Fly    91 SVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAA 155
            |..|.:.::.....|:.:.....:..|....:.:.||:.:.:...|||.|:|||.:.. |::||.
pombe    77 SQTVWASEVSYGDERIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDGN-TKYLAT 140

  Fly   156 TQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNM-PVQRTIRHASLKDYVWT-QFVESH 218
            ||.||..||.||||:|:|..:..|.|::.....|..|||| .|:.|:     ||.:.| :|.|:.
pombe   141 TQMEPTSARRAFPCWDEPALKATFTIDITAKENYTILSNMNAVEETV-----KDGLKTARFAETC 200

  Fly   219 PMQTYLVAFMISKFD-----RPGFTSSERSDC---PISTWARPDALSQTEFANMVVAPLLSFYED 275
            .|.|||:|:::::.:     .||      ..|   |:..:..|....|.:||..:.|..|.|:..
pombe   201 RMSTYLLAWIVAELEYVEYFTPG------KHCPRLPVRVYTTPGFSEQGKFAAELGAKTLDFFSG 259

  Fly   276 LFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWF 340
            :|...|...|.|:||:|||...:.|||||..:...::|. |:.|:....:.||..|...:.:|||
pombe   260 VFGEPYPLPKCDMVAIPDFEAGAMENWGLVTYRLAAILV-SEDSAATVIERVAEVVQHELAHQWF 323

  Fly   341 GNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVP 405
            ||||::.:|..:||...||.::|.|..:...|||...|.:......|.|..||..::..:...:.
pombe   324 GNLVTMQFWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPIEVPIM 388

  Fly   406 DESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRN 470
            .:..|...::.|...|.:.:..|:.:.:||:.::..:::|:..:......:.|.|..|..:
pombe   389 HDYEINQIFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTEDLWAALSAE---- 449

  Fly   471 GRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSY 535
                .|.:|:..|..|..:.|||:::|:...|.. .::.|.||..|...:.. .....:|.||
pombe   450 ----SGQDISSTMHNWTKKTGYPVLSVSETNDGE-LLIEQHRFLSTGDVKPE-EDTVIYWAPL-- 506

  Fly   536 TCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLE-----KLEAEPTDWILFNVQHTAPFRVNYDL 595
                          :..|....|.......||.:     |::.|..:....|.:.:..:||||..
pombe   507 --------------KLKTMKDGKAVVDEKAVLSDRSKKIKVDKEALESYKLNSEQSGIYRVNYSA 557

  Fly   596 RNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVW---- 656
            .:.:.|::...:...:..:.  :||.|:.|:.||:.:|..:....|.::...:.|..|||:
pombe   558 DHLKKLSQIAVEKPDYLSVE--DRAGLIADVASLSRAGYGKVSSTLDLIKTWKDEPNFVVFAEML 620

  Fly   657 -----VATEISFERINNVA---------------------KSNPNYLIFKTYMRLLLERQFKRVI 695
                 :.:.:.||..:.:|                     |:|.:::|          ||||
pombe   621 ARLNGIKSTLRFESSDIIAAMKKLVLEVSATKAHSLGWEFKANDDHII----------RQFK--- 672

  Fly   696 SSDLTSSSGNMTHRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE--RETVVCTAVKF 758
             |.:.:.:|......|:.....:::..|               .|....|.:  |..|...|:::
pombe   673 -STVYNYAGLFGDDKVVKDALSKFDAYA---------------SGNKSAINDNLRSAVFNIAIRY 721

  Fly   759 GTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVS 823
            |.....|.:..:|.::|....:.|.|.|...:.:...:|:.|..|.:.. |::|:.......:.:
pombe   722 GGAKSWDQLLEIYTKTNDPYVRNSCLRAFGVTEDEKYIQKTLDLTLDPI-VKEQDIYLILVTLST 785

  Fly   824 NSMGYRLAKKYVSVNMQNI 842
            :..|.....|:.:.|...:
pombe   786 HKNGVLAMWKFATSNWDKL 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	118/404 (29%)
		M1_APN_2	33..493	CDD:189008	127/469 (27%)
		ERAP1_C	579..897	CDD:288671	52/296 (18%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	197/860 (23%)
		M1_APN_2	27..468	CDD:189008	127/469 (27%)
		ERAP1_C	541..857	CDD:288671	52/296 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910