DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Lnpep

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_766415.1	Gene:	Lnpep / 240028	MGIID:	2387123	Length:	1025	Species:	Mus musculus

Alignment Length:	929	Identity:	253/929 - (27%)
Similarity:	431/929 - (46%)	Gaps:	102/929 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNA--HDLAIGKRRAVTLSDK 87
            |||..::||.|.:.:  ..|.....|.|:|.|.|::.:.|:.|:|::  |:::    |...:|
Mouse   167 RLPTAIIPLCYELSL--HPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNIS----RVTFMS-- 223

  Fly    88 NGNSVPVSSIQMDIKL------SRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHN 146
                 .|||.:..:::      .::.|....||.....|::::.:::.:.|...|||...|.|.:
Mouse   224 -----AVSSQEKQVEILEYPYHEQIAVVAPEPLLTGHNYTLKIEYSANISNSYYGFYGITYTDKS 283

  Fly   147 TTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVW 211
            .. .::.|||||||..||.||||||:|.|:..|.|.:.....:.||||||.:.::  .:.:..:.
Mouse   284 NE-KKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITRNEHHTALSNMPKKSSV--PAEEGLIQ 345

  Fly   212 TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDL 276
            .:|.||..|.||||||::.:...   .|.:.:...:|.:|.|:.:.|...|......||.||:..
Mouse   346 DEFSESVKMSTYLVAFIVGEMRN---LSQDVNGTLVSVYAVPEKIGQVHHALDTTIKLLEFYQTY 407

  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341
            |...|..||:||||:|||...:.|||||..|.||:||||:..||:.|::.|.:.:|..:.:||||
Mouse   408 FEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFG 472

  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPD 406
            |||::.||:::||...||.::..|.|..:..|.:..| ..|......:..|:..::..:::||..
Mouse   473 NLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYE-DFLDARFKTMRKDSLNSSHPISSSVQS 536

  Fly   407 ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNG 471
            ...|...::.:...|.|.|..||...:.|:.:..|:..||..::.....|.|.||......|
Mouse   537 SEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVILYLHNHSYAAIQSDDLWDSFNEVTD--- 598

  Fly   472 RLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWA-RNPCWWVPLSY 535
               |.|::.::||.|..|.|:|||||.|.  ....::.|:|||:..|..::.: .:..|.:|:||
Mouse   599 ---KTLDVKKMMKTWTLQKGFPLVTVQRK--GTELLLQQERFFLRMQPESQPSDTSHLWHIPISY 658

  Fly   536 TCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNW-Q 599
            ......:||..|        .|....||:.:.|    .|...|:..|...|..:.|:|...:| .
Mouse   659 VTDGRNYSEYRS--------VSLLDKKSDVINL----TEQVQWVKVNSNMTGYYIVHYAHDDWTA 711

  Fly   600 LLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISF- 663
            |:|:...:|   .::...:||.|::::|.||..|.:...||..::.||::|....  ..||..|
Mouse   712 LINQLKRNP---YVLSDKDRANLINNIFELAGLGKVPLRMAFDLIDYLKNETHTA--PITEALFQ 771

  Fly   664 --------ERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDL-TSSSGNMTHRPVIIRLACEY 719
                    |::.::..|  :.|:.:.:.  ||:.|.::...:|. |.|...:  |..::..||.:
Mouse   772 TNLIYNLLEKLGHMDLS--SRLVARVHK--LLQNQIQQQTWTDEGTPSMREL--RSALLEFACAH 830

  Fly   720 ELPACVSLARREFMKGTPEKGGWMTIRERET----VVCTAVKFGTEGDRD--MVESMYKRSNFAA 778
            .|..|.::|...|       ..||.....::    |:.|..|.|...::.  .:.|||......|
Mouse   831 SLENCTTMATNLF-------DSWMASNGTQSLPTDVMVTVFKVGARTEKGWLFLFSMYSSMGSEA 888

  Fly   779 EKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIR 843
            ||..:|.|||.|.:|..|..::..:.:...:|.|......:.|..:..|:.||..:|..|...:.
Mouse   889 EKNKILEALASSEDVHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRHFPGHLLAWDFVKENWNKLV 953

  Fly   844 NYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKI-----LLERGNDNIH 903
            :.....:..:.:::.......||...|.....||:      |.||..:|:     .||....||.
Mouse   954 HKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQAFFE------NQSEATLKLRCVQEALEVIQLNIQ 1012

  Fly   904 WQRTKFRPMLQAIRDIILW 922
            |       |::.::.:..|
Mouse  1013 W-------MVRNLKTLSQW 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	126/403 (31%)
		M1_APN_2	33..493	CDD:189008	143/467 (31%)
		ERAP1_C	579..897	CDD:288671	76/339 (22%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	126/404 (31%)
		M1_APN_2	177..617	CDD:189008	142/465 (31%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	690..1005	CDD:288671	75/338 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850