DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and LVRN

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	941	Identity:	263/941 - (27%)
Similarity:	433/941 - (46%)	Gaps:	114/941 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQ------PFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVT 83
            |||.|||||.|.:::..:: :|.:      ||.|.|.|.:|...:|.|::|  |.|.....||..
Human    97 RLPPWLVPLHYDLELWPQL-RPDELPAGSLPFTGRVNITVRCTVATSRLLL--HSLFQDCERAEV 158

  Fly    84 ---LSDKNGNS----VPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRND-NTGFYSS 140
               ||...||:    |||..:...:....:.:.|..|||...:|.::::|:.:::.| ..|.:.:
Human   159 RGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLN 223

  Fly   141 NYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHAS 205
            .|.|...  .:.|.|:|.||..||..|||||:|..:..|.|.:.|...|.||||||.........
Human   224 VYTDQGE--RRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKED 286

  Fly   206 LKDYVW--TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALS--QTEFANMVV 266
            :....|  |.|..:..|.||||||:|..:|....|...:.   |..|||.||::  ..:||..:.
Human   287 VNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKE---IRIWARKDAIANGSADFALNIT 348

  Fly   267 APLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAV 331
            .|:.||.|||||.:|...|.|::|||.|...:.|||||..|.|..||.:.:....:.:..::..|
Human   349 GPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVV 413

  Fly   332 AMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVN 396
            :..:.:|||||||::.||:.|||...||.|.....::...|:....|.....:..::|..|..:.
Human   414 SHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALV 478

  Fly   397 TDLVTASVPD--ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDF 459
            |..|...|.:  .|.|...::.....|.|.:..||...:.|..:::||:.||..::...|...|.
Human   479 TRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDL 543

  Fly   460 WDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNR-- 522
            |...|:.:|....:.....|..||..|..|.|:|::|:..:    |.::.|:.|:: ...:||
Human   544 WRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVS----TGVMKQEPFYL-ENIKNRTL 603

  Fly   523 WARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKP---SSKSNTVLLE-KLEAEPTDWILFNV 583
            ...|..|.||:                .|:...|::|   ..:|:.|..| ::.....||::.|:
Human   604 LTSNDTWIVPI----------------LWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNL 652

  Fly   584 QHTAPFRVNYDLRNWQLLNKTL-ADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYL 647
            ..|..:|||||...|:.||:.| .||....:|||:   ||:||.|||:.:..||.:.||.:..||
Human   653 NMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRL---QLIDDAFSLSKNNYIEIETALELTKYL 714

  Fly   648 EHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQ------FKRVISSDLTSSSGNM 706
            ..|||.:||....::....:.|::.| .|.|:....|.||:|.      :..:|..::.:...:.
Human   715 AEEDEIIVWHTVLVNLVTRDLVSEVN-IYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDY 778

  Fly   707 THRPVIIRL------ACEYELPACVSLARREFMKGTPEKGGWMTIRERE-------TVVCTAVKF 758
            .   .:|.|      ||...|..|:.|::..|.|       |:...|.|       .|:|..:..
Human   779 L---ALISLEKLFVTACWLGLEDCLQLSKELFAK-------WVDHPENEIPYPIKDVVLCYGIAL 833

  Fly   759 GTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVS 823
            |::.:.|::.:.|..:....||..|..|::||::.:.|.|.:.:...:|.. ..|.....:.|.|
Human   834 GSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF-TSNETNIIEVVAS 897

  Fly   824 NSMGYRLAKKYVSVNMQNI-RNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGS 887
            :.:|..:||.::..|.|.: :.|   .|..::||:..:...::|..:::...:||..:|.:
Human   898 SEVGRYVAKDFLVNNWQAVSKRY---GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEE---- 955

  Fly   888 ERLIKILLERGNDNIHWQRTKFRPMLQAIRD 918
                           | ||.:....||.|::
Human   956 ---------------H-QRIRVHANLQTIKN 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	133/415 (32%)
		M1_APN_2	33..493	CDD:189008	146/479 (30%)
		ERAP1_C	579..897	CDD:288671	85/338 (25%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91
		Peptidase_M1	97..506	CDD:279741	133/416 (32%)
		M1_APN_2	105..577	CDD:189008	146/479 (30%)
		Substrate binding. /evidence=ECO:0000250	379..383		0/3 (0%)
		ERAP1_C	648..951	CDD:288671	84/320 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850