DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Npepps

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	938	Identity:	239/938 - (25%)
Similarity:	391/938 - (41%)	Gaps:	143/938 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQP------FGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVT 83
            |||..:.|::|.:.:        :|      |.|.:....:..::|.:||:|..|:.|     :|
Mouse    54 RLPAEVSPINYSLCL--------KPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI-----IT 105

  Fly    84 LS--DKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHN 146
            .|  .:....:..:......:..::|:|....|:.. |.::::.|...|.:...|||.|.|
Mouse   106 ASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTG-TGTLKIDFVGELNDKMKGFYRSRY---- 165

  Fly   147 TT---LTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKD 208
            ||   ..::.|.||||...||.||||:|:|..:..|.|:|..|....|||||.|.....:...::
Mouse   166 TTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDEN 230

  Fly   209 YVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSD--CPISTWARPDALSQTEFANMVVAPLLS 271
            .|..:|..:..|.||||||::.::|   |..:...|  | :..:.......|.:||..|.|..|.
Mouse   231 LVEVKFARTPVMSTYLVAFVVGEYD---FVETRSKDGVC-VRVYTPVGKAEQGKFALEVAAKTLP 291

  Fly   272 FYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVV 336
            ||:|.||..|...||||:|:.||...:.|||||..:.|.:||.|.:.|....:|.||..|...:.
Mouse   292 FYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELA 356

  Fly   337 NQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVT 401
            :|||||||::.||..:||...||.::....|....||:|...:.....|....:.||..|:..:.
Mouse   357 HQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE 421

  Fly   402 ASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQ 466
            .||...|.:...::.|...|.|.:..|||..:|::.:...:..||..:..:.|.:.|.|:.|:
Mouse   422 VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLE-- 484

  Fly   467 VDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNY--DHRTAIVSQQRFFITPQFRNRWARNPCW 529
                  ...|..|..:|..|..|.|:||:.|....  |.|...:||::|..:..:.....  |.|
Mouse   485 ------SASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDC--PQW 541

  Fly   530 WVPLSYTCPSCQHSEIISFSRWLTCPTSK-PSSKSNTVLLEKLE-------AEPTDWILFNVQHT 586
            .||                   :|..||: |:.....:|::|.|       .:|..|:..|:...
Mouse   542 MVP-------------------ITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTV 587

  Fly   587 APFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHED 651
            ..:|..|.....:.|...:.|.:    :..|:|..|.:||||||.:|.|.....|.::....:|.
Mouse   588 GFYRTQYSSAMLESLLPGIRDLS----LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEP 648

  Fly   652 EFVVW---------VATEIS----FERINNVAKSNPNYLIFKTYMRLL----------LERQFKR 693
            .:.||         ::|.:|    :|.|....|.     :|......|          |:...:.
Mouse   649 NYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKD-----VFSPIGERLGWDPKPGEGHLDALLRG 708

  Fly   694 VISSDLTSSSGNMTHRPVIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKF 758
            ::...|    |...|:             |.:..|||.| |...|....::...|..|..|.:|.
Mouse   709 LVLGKL----GKAGHK-------------ATLEEARRRF-KEHVEGKQILSADLRSPVYLTVLKH 755

  Fly   759 GTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVS 823
            |.....|::..::|:::...||..:...|..:.:...:|:||.:.. |..||.|:.......|..
Mouse   756 GDGATLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKVLTFAL-SEEVRPQDTVSVIGGVAG 819

  Fly   824 NSM-GYRLAKKYVSVNMQNIRNYCSNS--TDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMN 885
            .|. |.:.|.|::..|.:.:.|.....  ..:::.|.   :|..:..|.......||:.  ....
Mouse   820 GSKHGRKAAWKFIKDNWEELHNRYQGGFLISRLIKLS---VEGFAVDKMAGEVKAFFES--HPAP 879

  Fly   886 GSERLIK-----IL-----LERGNDNIH 903
            .:||.|:     ||     |:|..|:||
Mouse   880 SAERTIQQCCENILLNAAWLKRDADSIH 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	123/408 (30%)
		M1_APN_2	33..493	CDD:189008	137/472 (29%)
		ERAP1_C	579..897	CDD:288671	73/353 (21%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	123/409 (30%)
		M1_APN_2	62..505	CDD:189008	137/472 (29%)
		Substrate binding. /evidence=ECO:0000250	317..321		0/3 (0%)
		ERAP1_C	580..891	CDD:288671	70/343 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820