DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	732	Identity:	178/732 - (24%)
Similarity:	309/732 - (42%)	Gaps:	101/732 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTILTALFFHLEANKTAVG--RLPKWLVPLSYRVDIVTRINQPYQP------------FGGTVVI 56
            |.|:......|:|....|.  |||:.:.|..|.:.|.|     |.|            |.|.|.|
Worm    10 LAIIKPFASELDARIADVASYRLPRHVSPSHYDIHIKT-----YLPGYGWKADENKITFEGNVNI 69

  Fly    57 DLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYS 121
            .|..:.:|.::||::..|.|  ..|...||:...|:...::|.:.:.  ||..|...:||..:..
Worm    70 LLDIKETTDKLVLHSSSLNI--ISATFQSDEQNVSISHWNVQTESQF--LTFYLNNTVKVQSSAG 130

  Fly   122 MRVAFTSVLRNDNTGFYSSNYV-DHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAH 185
            :::.|...:|.|..|.:::|.. :..|.:|.:  |||||...||...||||:|.|:..:.::|.|
Worm   131 IQINFQGKVRTDGLGLFATNSTREDGTVMTNF--ATQFETIFARNMIPCFDEPEFKATWNVSLEH 193

  Fly   186 PYLYRALSN-MPVQRTIRHASLKDYVWTQFVESHPMQTYLVAFMIS--KFDRPGFTSSERSDCPI 247
            |....|||| :.|:..:.    .|:..|.:.::..|.:|::|..|.  :|......:..|    |
Worm   194 PTGSTALSNGIEVESKVN----DDWKTTTYKKTLKMSSYILALFIGDIQFKETILNNGVR----I 250

  Fly   248 STWARPDALSQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESL 312
            ..:..|..:.:.:.|..:...:|..:|..|...|..:|:|.|::.:|.|.:.||||        |
Worm   251 RVYTDPVNIDRVDHALNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFGAMENWG--------L 307

  Fly   313 LYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQ 377
            :..:..|.|.|...|...|...:.:|||||||::.:|..|||...||.|::.:|:..|.|  |||
Worm   308 VIHNAYSLIGDPMDVTEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYMTSYGLTFLDP--DYQ 370

  Fly   378 ERHALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGE--RKAAVLFEMLHRVMGEEAWLT 440
            ..   ..||: ..::..:|...|  |:....::.:..|....  .|......||..:.|.|.:..
Worm   371 RD---TFYLN-CQFNPQINDGGV--SLNFGKNLSSVMNNAATVYMKGCSFVRMLENIFGTEYFNE 429

  Fly   441 ALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRT 505
            |::.||..........:|.::..:...:.....||..:|.:..:||..|.|:|.:.|:.  |:..
Worm   430 AIKFYLEKNQYDNVDDNDLYEAFRTSSETLDTNGKPFDIEKFARCWTHQNGFPTIQVSN--DNGI 492

  Fly   506 AIVSQQRFFITPQFRNRWARNPC---WWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVL 567
            |.::|...: .||.    ..|.|   |.:|:.|..|.....::    .||        ::::|
Worm   493 ATLTQSHLY-EPQL----MLNECDYKWDIPIWYQEPGEARVQM----AWL--------NRNST-- 538

  Fly   568 LEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWS 632
              .||....|.::.|......:.|.|..:.::.:.:.:|.......::.:.|.  :.|:|..:..
Worm   539 --SLELVADDSVIINANSIGYYEVLYSDKMYEKIAEQVAINVSRYSVNSLRRT--LHDVFRYSRD 599

  Fly   633 G--------DIEYDMALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLER 689
            |        .|.|.:..|....|.||.  |:::...:    .|...||..|....:|...|:.:.
Worm   600 GLTPFHNAFIIAYVLVFGENEILRHES--VLYLVDAV----YNTNNKSIVNSKDIETVKGLVNQI 658

  Fly   690 Q----FKRVISSDLTSS 702
            :    |.:.:.|...||
Worm   659 ENFELFPKCVQSQTFSS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	113/413 (27%)
		M1_APN_2	33..493	CDD:189008	125/477 (26%)
		ERAP1_C	579..897	CDD:288671	25/136 (18%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	110/390 (28%)
		M1_APN_2	39..482	CDD:189008	125/477 (26%)
		ERAP1_C	548..>622	CDD:288671	11/75 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850