DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and pam-1

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	972	Identity:	243/972 - (25%)
Similarity:	407/972 - (41%)	Gaps:	156/972 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FHLEAN---KTAVG-----------------RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDL 58
            :|..||   :||.|                 |||.:..|..|.|.:...:||  ..|.|...||:
Worm    48 YHTTANMLHRTARGEHGMAACGNPSAAVKFERLPTFAEPTHYNVRLSPCLNQ--FSFDGHATIDV 110

  Fly    59 RSERSTKRIVLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSL---KRPLKVNVTY 120
            ..:.:|..:.::|..|.|   ::|:|..:.|::........|.||:.||:.|   .:|.||.:.:
Worm   111 TIKEATDVLKVHAQSLLI---QSVSLITQPGDASKSLETSYDDKLNILTIKLPTTMQPQKVQLDF 172

  Fly   121 SMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAH 185
            .    |...|.:...|||.|.|.|.|.| .::||:||||..:||.||||||:||::..|.:.|..
Worm   173 K----FVGELNDKMRGFYRSQYKDKNGT-EKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEV 232

  Fly   186 PYLYRALSNMPVQRTIRHASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTW 250
            .....|||||.|......|..|....| |..|..|.:|||||.:.:.:.  .::..:|...:..:
Worm   233 ENHLTALSNMNVISETPTADGKRKAVT-FATSPKMSSYLVAFAVGELEY--ISAQTKSGVEMRVY 294

  Fly   251 ARPDALSQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYD 315
            ..|....|.:::..:....:.:|.:.|:..|...|.||:|:|||:..:.|||||..:.|.:||.|
Worm   295 TVPGKKEQGQYSLDLSVKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVD 359

  Fly   316 SQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPE---WDYQ 377
            ...:|...:..||..||..:.:.||||||::.||.::|||..||.::....|.:..||   |
Worm   360 PGVTSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIW--- 421

  Fly   378 ERHALQLYL-SVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTA 441
             .|.|...| |.:..||..|:..:...:.:.:.:...|:.|...|:..:..||...:.|..:...
Worm   422 -LHFLNDELASGMGLDALRNSHPIEVEIDNPNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKG 485

  Fly   442 LRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTA 506
            ||.||..:....|.:.|.|..|.        ...|.|:..:|..|..|.|:|::.|::..|....
Worm   486 LRLYLKRFQYSNAVTQDLWTALS--------EASGQNVNELMSGWTQQMGFPVLKVSQRQDGNNR 542

  Fly   507 IVS-QQRFFITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEK 570
            |:: :||.||:....:  .:|..|.||::                  ....|.||......||::
Worm   543 ILTVEQRRFISDGGED--PKNSQWQVPIT------------------VAVGSSPSDVKARFLLKE 587

  Fly   571 LEAE-------PTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFS 628
            .:.|       |.:|:..|...|..:||.|   :.::|...|.|... |.:..::|..|::||.:
Worm   588 KQQEFTIEGVAPGEWVKLNSGTTGFYRVEY---SDEMLTAMLPDIAS-RRMPVLDRFGLINDLSA 648

  Fly   629 LAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFERINNVAK-------SNPNYLIFKTYMRLL 686
            |..:|.:.....:.:......|||:|||.|.:....::...|:       .:...|:.|.:.:..
Worm   649 LLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREMSEDTLKSAKQLVVKMFEQTG 713

  Fly   687 LERQF---------KRVISSDLTSSSGNMTHRPVIIRLACEYELPACVSLARREFM-KGTPEKGG 741
            .|..|         |.::.|.:.:......|:|.|.:....:          .:|: ||||
Worm   714 AELGFAEQAGEDSQKMMLRSLVQARLARAGHQPTIDKFTQMF----------NDFLEKGTP---- 764

  Fly   742 WMTIRE--RETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTF 804
               |..  |........::|.:...|.:.::.:.:.|...:...:.|::.:.....|.::..:.|
Worm   765 ---IHPDIRLATFGVVARYGGKEGFDKLMNLRETTTFQEIERQTMVAMSQTPEESLLAQLFEYGF 826

  Fly   805 ESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIE-CL---- 864
            |.:.||.|:....|....:..||.:.|.||.   .::|:.:    .||.....:.|.: ||
Worm   827 EKNKVRPQDQLYLFLGTGATHMGQQYAWKYF---CEHIKEF----LDKYGGANSSLFQRCLKFAG 884

  Fly   865 ---STPKELLYFSKFF--KEILRDMNGSERLIKILLERGNDNIHWQRTKFRPMLQAIRDIIL 921
               ...|..:.|..||  ..:|.|.:                   ::|..||:.|.:..|.|
Worm   885 ESFGNEKRAVEFQDFFCNCNVLSDTD-------------------RQTLARPIGQTVEAIRL 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	126/402 (31%)
		M1_APN_2	33..493	CDD:189008	140/466 (30%)
		ERAP1_C	579..897	CDD:288671	67/346 (19%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	140/466 (30%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	73/371 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020