DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Y67D8C.9

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001122826.1	Gene:	Y67D8C.9 / 177088	WormBaseID:	WBGene00022073	Length:	1144	Species:	Caenorhabditis elegans

Alignment Length:	1058	Identity:	252/1058 - (23%)
Similarity:	416/1058 - (39%)	Gaps:	248/1058 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LEANKTAVGR----LPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAI 76
            :.|||.:...    ||.:::|..|.:.:.......:......:.|.|.|..::....:..|   :
Worm   168 VRANKLSTDALLVPLPLYILPYHYDLQLDFSQFDTHLFIRANISIHLESYGNSTEDEIQFH---L 229

  Fly    77 G---KRRAVTLSDKNGNSVPVSSIQMD--IKLSRLTVSLKRPLK-----VNVTYSMRVAFTSVLR 131
            |   |...:.|. |:|......:.:.:  .||.|  :||:.||:     :.:||:|     ::..
Worm   230 GPNIKMERMRLR-KDGKKFYAKTFKREESKKLGR--ISLRDPLQKGKYILEMTYNM-----TICD 286

  Fly   132 NDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMP 196
            .|..|...|.....|::|......|:|||..||..|||:|:|..:..|.|::.|...|..|||||
Worm   287 EDVDGVRCSLDNQTNSSLKATSFTTKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTVLSNMP 351

  Fly   197 VQRTIRHASLKD-YVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTE 260
            ...:..|.|.:| :..|.|..:.||.|||:||.|.:|.:  ..|......|::.|..|:.:...:
Worm   352 PVESHDHKSWEDQFKTTVFQTTPPMSTYLLAFAIGEFVK--LESRTERGIPVTVWTYPEDVMSMK 414

  Fly   261 FANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLY-----DSQRSS 320
            |.......:....||.....|...|:||:|..:|.....|||||..|...|:.|     |....:
Worm   415 FTLEYAPVIFDRLEDALEIPYPLPKVDLIAARNFHVGGMENWGLVVFEFASIAYTPPITDHVNET 479

  Fly   321 ID---DQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRP---EWDYQER 379
            :|   ::..:.:.:|....:|||||||::..|.|::|...||.:.....:.:.||   :::|.:.
Worm   480 VDRMYNEFRIGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPVTAQFEYYDS 544

  Fly   380 HA-LQLYLSVLDYDAHVNTDLVTASVPDES-HIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTAL 442
            .| |.|..|..|:...:..:|.|.|..:.| |....|.     |..||..||..::.:..:..|:
Worm   545 LASLILAQSEEDHRLSLVRELATESQVESSFHPTNLYT-----KGCVLIRMLRDLVSDFDFKAAV 604

  Fly   443 RRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAI 507
            ||||...|.|:.:..|.:..|....|......|   ::.:::.|....|.|.:|:.||||:....
Worm   605 RRYLRKNAYRSVSRDDLFASLPAYADHGAEQEK---LSHVLEGWFVNEGIPEITLIRNYDNEMMT 666

  Fly   508 VSQQ-------RFF--------------------------------------------------- 514
            :||:       |.|
Worm   667 ISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKKDRRRKHRPIRRKT 731

  Fly   515 -----ITPQFRNRWARNP--------CWWVPLSYTCPSCQHSE---IISFSRWLTCPTSKPSSKS 563
                 |:|..|....|.|        .|.:|::|...|.:.||   |..|  ||         |:
Worm   732 STPPSISPISRRDELRKPRRVGASQDLWTIPITYMFGSLKTSEGQVIREF--WL---------KN 785

  Fly   564 NTVLLEKLEAEPTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFS 628
            .||.....|..|...:|.|.:...|:||||||.||:||.:|| ..|... |:..:|.||:.|. .
Worm   786 RTVSFGDAEISPNQAVLVNPEWKYPYRVNYDLLNWKLLARTL-HQNHLE-INEKSRMQLILDA-E 847

  Fly   629 LAWSGDIEYDMALGILGYLEHEDEFVVW---VATEISFERINNVAKSNPNYLIFKTYMRLLLERQ 690
            ...|..:...:.|.:||||.||.:..|.   :.....|..:....:.|...|::
Worm   848 YFLSNSVNPHLYLYLLGYLAHETKMEVMLFGIDAVYKFIDVYKATQLNKAILVY----------- 901

  Fly   691 FKRVIS--------SDLTSSSGNM-THRP----VIIRLACEYELPACVSLARREFMKGTPEKGGW 742
            |:.|||        |.:.:.:.:: ..||    .:.::.|...|.:|.:....:....:|::  |
Worm   902 FEPVISQMDHLLNESQVDAETASLWLVRPERLAKLYQMRCAAGLSSCKNDYYTQRWSRSPDE--W 964

  Fly   743 M-TIRERETVVCTAVKFGTEGD----RDMVESMYKRSNFAAEKESLLTAL-ACSRNVFALQRVLI 801
            . .:.::.|.||..:...|..:    :|:::|   |...:..|.:|...| |||.:    |::|
Worm   965 TEDVHKQVTAVCHQLFTNTPDEVKTVQDLLDS---RLQSSGAKWALTVQLAACSHD----QKLL- 1021

  Fly   802 WTFESSGVRKQNARRTFKAVVS--NSMGYRLA-------------KKYVSVNMQNIRN------Y 845
                         |||.:|:||  |::.|..|             :||:...:..:..      :
Worm  1022 -------------RRTARAIVSTKNAVVYASALQSDFSLHYNPTFRKYLWAEIAKMSTFEKTALF 1073

  Fly   846 CSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHWQRTKFR 910
            .:||||           .|...:.||:..|...|:        :.|:.||           |.:.
Worm  1074 STNSTD-----------ILPASRILLHSVKTIDEL--------QQIRGLL-----------TNWG 1108

  Fly   911 PML----QAIRDIILWRS 924
            |:|    :.:...:||.|
Worm  1109 PLLSLHFEYLERYLLWVS 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	112/423 (26%)
		M1_APN_2	33..493	CDD:189008	127/483 (26%)
		ERAP1_C	579..897	CDD:288671	83/360 (23%)
Y67D8C.9	NP_001122826.1	Peptidase_M1	182..584	CDD:279741	112/419 (27%)
Y67D8C.9	NP_001122826.1	M1_APN_2	190..652	CDD:189008	127/482 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020