DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Y53F4B.20

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_497105.3	Gene:	Y53F4B.20 / 175160	WormBaseID:	WBGene00013166	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	740	Identity:	144/740 - (19%)
Similarity:	271/740 - (36%)	Gaps:	163/740 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDI---VTRINQPYQP-FGGTVVI----------------DLRSERSTKR--- 66
            |||..|.||||.:.:   ::.::.|..| |.|..|:                |..|.|:..:
Worm    31 RLPPILKPLSYDLQLQLPLSEVSDPDVPLFTGRCVMHFEINQQIGPESAFISDSTSNRARIKFDI 95

  Fly    67 ----------IVLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYS 121
                      :|:|.|:|.|..   |.|:|   :|:.:|..|..:...|.|:::.|
Worm    96 IMLDHFENVSLVMNGHELEIFN---VQLTD---DSMELSVDQPVLFPGRYTLTIHR--------- 145

  Fly   122 MRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHP 186
                :..::   .:..|..:..:|.      :..:...||.|...||.:.....:..|.|.:.||
Worm   146 ----YKGLI---GSAIYYRDAGEHA------VFGSNLFPNRAPAVFPSYLASTEKVTFSITMVHP 197

  Fly   187 YLYRAL---SNMPVQRTIRHASLKDYVW--TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCP 246
            ....||   ||....|.|      |..|  |.|..:..:...::.|::...:   :|..|.:...
Worm   198 VGTLALTSGSNEGAPRKI------DENWQMTTFSTTPSITPSMLCFLLLPHE---YTHIESTYTG 253

  Fly   247 ISTWARPDAL----SQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAF 307
            ::.....:..    .||:........:|:..:|:|:|.....|||::.:.:.:  |...:|
Worm   254 VNISVHYNRFRVQKEQTKHLLHTATQVLALLKDIFSSLIPVPKIDIITMNEVS--STACFG---- 312

  Fly   308 AEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRP 372
               |::....:....|.....:.:|..:..||.|...:::...|:.|:.....:::...:..:..
Worm   313 ---SIVVSEVQFFSADYANQVKMLATWLAKQWIGGYAAISEGSELCLQEDLVAFIADKVIKRMTN 374

  Fly   373 EWDYQERHALQLYLS--------VLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEML 429
            :...:..|..::|||        .|..|.|          |:|..|   :.:.|.:..|:| |.:
Worm   375 DEFTRLGHLAKIYLSETIFTAGDTLKLDEH----------PNEFEI---FEKCGLKGVAML-ESI 425

  Fly   430 HRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPL 494
            ..::||::.::.:...:......:.:|...:.||...||.:      :.:::::..|....|.|.
Worm   426 ESLIGEKSMISKINEMIYNSKKGSYSSRTLYGLLNSTVDED------IYVSQLLHYWHEHGGLPY 484

  Fly   495 VTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKP 559
            :.|.| ..:...|...............|.|.|.|.:||.:|........::|..
Worm   485 MNVDR-LANSIKITQNGSNMTVKNGAGTWERMPLWPLPLKFTEFKLPIQIMVSHG---------- 538

  Fly   560 SSKSNTVLLEKLEAEP-TDWILF-NVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQL 622
                       :...| .|.::| |:..|..:|||||:..|:.: ||:...|......| .|.||
Worm   539 -----------IHLSPIRDGLIFSNLGFTNYYRVNYDIDTWREI-KTVLTENATSYTLR-ERFQL 590

  Fly   623 VDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEIS---------FERINNVAKSNPNYLI 678
            |.| |...:|.....:.|..:|     .:|||..|....:         |:.:.....:.|.:|.
Worm   591 VSD-FCYFYSIKSLPEPAASVL-----RNEFVQLVRLRPTSFPICDAAIFQCVVTHEHTKPRHLD 649

  Fly   679 FKTYMRLLLERQFKRVISSDLTSSS 703
            ..|.:      |.:|.:.....:||
Worm   650 KSTMV------QLRRKVFDSFANSS 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	84/445 (19%)
		M1_APN_2	33..493	CDD:189008	91/509 (18%)
		ERAP1_C	579..897	CDD:288671	34/135 (25%)
Y53F4B.20	NP_497105.3	GluZincin	39..>300	CDD:301352	58/297 (20%)
Y53F4B.20	NP_497105.3	ERAP1_C	552..>593	CDD:288671	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910