DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and F49B2.6

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_493503.2	Gene:	F49B2.6 / 173297	WormBaseID:	WBGene00009865	Length:	1082	Species:	Caenorhabditis elegans

Alignment Length:	929	Identity:	224/929 - (24%)
Similarity:	413/929 - (44%)	Gaps:	104/929 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LEANKTAV------GRLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDL 74
            ::|||...      .|||:...|:.|  |:....|........:|.|.:..:..||.::|||.:|
Worm   184 VKANKECTNITWYSSRLPRTAEPIDY--DLTLHPNLTNGEVEASVSIRILIKNDTKLLILNAENL 246

  Fly    75 AIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYS 139
            .: |...:|   |.|..|....::..: :::....|.:.|.......:.:.:::.:::|..|.|.
Worm   247 EM-KSFDIT---KKGAKVKADFVKCAV-MTQWAWKLAKRLHKGDHIVLTIYYSAQMKSDLQGLYF 306

  Fly   140 SNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKIN-LAHP-YLYRALSNMPVQRTIR 202
            |.::..:...|: .|||||||..||:..||||:|.|:..|::. :.:| ::.|:..|:.:.:..:
Worm   307 STHLGTDGKKTK-SAATQFEPTFARKMLPCFDEPNFKATFQVAIIRNPHHIARSNMNILISKEYK 370

  Fly   203 HASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGF----TSSERSDCPISTWARPDALS-QTEFA 262
            :..:||.    |.:|..|.|||:|  ::..|..|:    |.:.:....:..:|..|.|: |:||.
Worm   371 NGLIKDV----FEKSVKMSTYLLA--VAVLDGYGYIKRLTRNTQKAIEVRLYAPQDMLTGQSEFG 429

  Fly   263 NMVVAPLLSFYEDLFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGV 327
            .......|.|:||.||.:|...||||:||.||:..:.|||||..|.:.:||::.:::|:..::.:
Worm   430 LDTTIRALEFFEDYFNISYPLDKIDLLALDDFSEGAMENWGLVTFRDSALLFNERKASVVAKEHI 494

  Fly   328 ARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYD 392
            |..:...:.:|||||||::.||:|::|...||.|:....|..|.|:|....|    .|...|.:.
Worm   495 ALIICHEIAHQWFGNLVTMDWWNEVFLNEGFANYMEYKCVEHLFPDWSIMSR----FYAENLAFS 555

  Fly   393 AHVNTDLVTASV--PDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTAT 455
            ...:..|.:.::  .|:..:...::.|...|||.:..|:..:.|::.:..||..||..||...|.
Worm   556 QEPDGFLSSRAIESDDDDSLLNLFDAINYHKAAAIIHMIAEMAGQKNFQNALVEYLNKYAYSNAI 620

  Fly   456 SSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI----- 515
            ..|.|.:    |:::..|...::|..:.|.:..|.||||:||.|. |....:.:|.||..
Worm   621 GVDLWKI----VEKHANLQGTVSIPDLAKAYTTQVGYPLLTVERT-DEGVLVHNQTRFLFAEGDK 680

  Fly   516 TPQFRNRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWIL 580
            ..:.|..|.    |.:|:||.  ..:|..  ....|:     :...|:.|     .|....||::
Worm   681 AEEKRGDWK----WPIPISYR--DSEHRR--KKQHWI-----QADDKNVT-----WETTSNDWLI 727

  Fly   581 FNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILG 645
            .|......|:|.||...::.|.|.|  ......|..::|:.::.|.|.|:.:..:...:...:|.
Worm   728 LNTGGVGYFKVLYDPETYRKLVKQL--QRNHTTISPIDRSMILVDSFDLSKTSLLNISVYFDLLE 790

  Fly   646 YLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTHRP 710
            |:|.|.:.:.|.........|..:.:.:....|::.:.|.|:.|.::   |.|......|...:.
Worm   791 YVEKETDKMTWSIVGKQLRTIEALIEESDYLDIYQDFQRSLIMRLYE---SLDWDEQGANPNQKR 852

  Fly   711 V---IIRLACEYELPACVSLARREFMKGTPEKGGWMT--IRERE---TVVCTAVKFGTEGDRDMV 767
            :   |..:||..::..|...|.:.:::       |::  :|..|   ..:...||.|.....:.:
Worm   853 LQVDIFAVACRLQIKDCTKQAYQRYLQ-------WVSSGVRNPEHHMIALMEGVKQGETTAWERI 910

  Fly   768 ESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAK 832
            ...||.:...:||.:::.||..:::...:.|:|.:..:.. ::.....|.|.....|.....:..
Worm   911 WKAYKTATSPSEKNNIIGALTSTKDASLINRLLKYCLDGK-IKANLIPRVFSYFSLNQSTRNIVW 974

  Fly   833 KYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTP----------KELLYFSKFFKEILRDMNGS 887
            |:...:.:.........     :||...::||:.|          ||.|...||.::.|..|..:
Worm   975 KFFKTHFEQFHGILGKG-----SLMASCVKCLAEPLSTETELEEVKEFLKSQKFAEDGLIKMEMT 1034

  Fly   888 ERLIKILLERGNDNIHWQR 906
            ...|::       ||.|::
Worm  1035 YEQIEL-------NIQWRK 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	113/404 (28%)
		M1_APN_2	33..493	CDD:189008	129/468 (28%)
		ERAP1_C	579..897	CDD:288671	62/335 (19%)
F49B2.6	NP_493503.2	Peptidase_M1	199..586	CDD:279741	113/404 (28%)
		M1_APN_2	207..654	CDD:189008	129/468 (28%)
		ERAP1_C	726..1037	CDD:288671	61/328 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920