Protein Alignment CG2111 and Lta4h

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 671
• Identity: 149/671 - (22%)
• Similarity: 234/671 - (34%)
• Gaps: 186/671 - (27%)

  Fly    52 GTVVIDLRS-ERSTKRIVLNAHDLAI------GKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVS 109
            ||..:.::| |.:.:.:.|:..||.|      |:....||.:..|           .|.|.:.:|
Mouse    37 GTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQG-----------YKGSPMEIS 90

  Fly   110 LKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAA------------TQFEPNH 162
            |...|..|....:.::|.:               ...::..|||..            :|.:..|
Mouse    91 LPIALSKNQEIVIEISFET---------------SPKSSALQWLTPEQTSGKQHPYLFSQCQAIH 140

  Fly   163 AREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHA--------SLKDYVWTQFVESHP 219
            .|...||.|.|..:..:...::.|....||.:     .||..        |.|.|.:.|.|   |
Mouse   141 CRAILPCQDTPSVKLTYTAEVSVPKELVALMS-----AIRDGEAPDPEDPSRKIYRFNQRV---P 197

  Fly   220 MQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDAL--SQTEFANMVVAPLLSFYEDLFNSTYR 282
            :..||:|.::      |...|.:.......|:..:.:  |..||:.  ...:|...||| ...|.
Mouse   198 IPCYLIALVV------GALESRQIGPRTLVWSEKEQVEKSANEFSE--TESMLKIAEDL-GGPYV 253

  Fly   283 QKKIDLVAL-PDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSV 346
            ..:.||:.| |.|.:...||..|.......|..|...|::         :|..:.:.|.||||:.
Mouse   254 WGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNV---------IAHEISHSWTGNLVTN 309

  Fly   347 AWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHAL----QLYLSVLDY-DAHVNTDLVTASV-- 404
            ..|...||.....:||.|.....|..| .::..|||    :|..::..: ::|..|.||....
Mouse   310 KTWDHFWLNEGHTVYLERHICGRLFGE-KFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDV 373

  Fly   405 -PDESHIWAAYNEIG-ERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFW------- 460
             ||     .||:.|. |:..|:||.:...:.|.|.:|..|:.|:..::.::.|:.| |
Mouse   374 DPD-----VAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDD-WKSFLYSH 432

  Fly   461 -----DLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFR 520
                 |||. |||.|              .||..||.|  .|..|||
Mouse   433 FKDKVDLLN-QVDWN--------------TWLYAPGLP--PVKPNYD------------------ 462

  Fly   521 NRWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQH 585
                      |.|:..|       |....||:|......||.| ...|:.|.:...:..|..|..
Mouse   463 ----------VTLTNAC-------IALSQRWVTAKEEDLSSFS-IADLKDLSSHQLNEFLAQVLQ 509

  Fly   586 TAPFRVNY-----DLRNWQLLNKT----------------LADPNKFRLIHRVNRAQLVDDLFSL 629
            .||..:.:     ::.|:..:|.:                .|.|...::.....|.:....||..
Mouse   510 KAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKD 574

  Fly   630 AWSGDIEYDMALGILGYLEHE 650
            ..:.|..:|.|  :..|.||:
Mouse   575 LAAFDKSHDQA--VHTYQEHK 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	111/485 (23%)
		ERAP1_C	578..897	CDD:463368	17/94 (18%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	149/671 (22%)