DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Anpep

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	930	Identity:	266/930 - (28%)
Similarity:	421/930 - (45%)	Gaps:	105/930 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDI---VTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAI---GKRRAVT 83
            ||||.|:|.||||.:   :|..||....|.|...:.....::|..|::::..|..   |..| |.
Mouse    75 RLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHR-VV 138

  Fly    84 LSDKNGNSVP-VSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNT 147
            |...:|...| :...::..:...|.|.|:..|.....|.|...|...|.:|..|||.|.|::.:
Mouse   139 LRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGD- 202

  Fly   148 TLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWT 212
             :.:.:|.||.:...||::|||||:|..:..|.|.|.:|....|||||..:.:..:........|
Mouse   203 -VKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMT 266

  Fly   213 QFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDAL--SQTEFANMVVAPLLSFYED 275
            :|..:..|.|||:|:::|:|  ...:|...:...|..||||.|:  .|.::|..|..|:|:|:..
Mouse   267 EFHSTPKMSTYLLAYIVSEF--KNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQ 329

  Fly   276 LFNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWF 340
            .:|::|...|.|.:|||||...:.|||||..:.|.||::|||.|||.:::.|...:|..:.:|||
Mouse   330 HYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWF 394

  Fly   341 GNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTA--- 402
            ||||:||||:::||...||.|:...|.....|.|:.::...|.....|:..||..::..:::
Mouse   395 GNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPAD 459

  Fly   403 --SVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQL 465
              ..||:  |...::.|...|.|.:..||...:.|:.:...|..||..|........|.|:.||.
Mouse   460 EIKTPDQ--IMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQK 522

  Fly   466 QVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWAR----N 526
            .|::...:.....:..||..|:.|.|:|::||..|    |..:||:.|.:  ..::...|    |
Mouse   523 AVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTN----TGEISQKHFLL--DSKSNVTRPSEFN 581

  Fly   527 PCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRV 591
            ..|..|:.: ..|.|....     ||....::.:         |.:....:|||.|:..|..:.|
Mouse   582 YIWIAPIPF-LKSGQEDHY-----WLDVEKNQSA---------KFQTSSNEWILLNINVTGYYLV 631

  Fly   592 NYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVW 656
            |||..||:.|...|  .....:|..:||||::.|.|:||.:..|...:||....:|..|.|::.|
Mouse   632 NYDENNWKKLQNQL--QTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPW 694

  Fly   657 VATEISFERINNVAKSNPNYLIFKTYMRLLLERQ-----FKRVISSDLT-------SSSGNMTHR 709
            .|           |.|:.|      |..|:.:|.     .||.:...:|       :.:.|..:|
Mouse   695 QA-----------ALSSLN------YFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNR 742

  Fly   710 PV----------IIRLACEYELPACVSLARREFMKGTPEKGGWM------TIRE--RETVVCTAV 756
            |.          .|..||...|..|..|....:.:       ||      ||..  |.||.|.|:
Mouse   743 PPTLMEQYNEINAISTACSSGLKECRDLVVELYSQ-------WMKNPNNNTIHPNLRSTVYCNAI 800

  Fly   757 KFGTEGDRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAV 821
            .||.|.:.:.....::.:....|.:.|.:|||||::|:.|.|.|.:|.....:|||:...|..::
Mouse   801 AFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISI 865

  Fly   822 VSNSMGYRLAKKYVSVNMQNI-RNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMN 885
            .||..|:.|...:|..|.:.: .||...|. ...||:..:....|:..||....:|..:......
Mouse   866 ASNVAGHPLVWDFVRSNWKKLFENYGGGSF-SFANLIQGVTRRFSSEFELQQLEQFKADNSATGF 929

  Fly   886 GS-ERLIKILLERGNDNIHW 904
            |: .|.::..||:...||.|
Mouse   930 GTGTRALEQALEKTRANIDW 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	132/409 (32%)
		M1_APN_2	33..493	CDD:189008	145/473 (31%)
		ERAP1_C	579..897	CDD:288671	93/349 (27%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64
		Metalloprotease	69..966		266/930 (29%)
		M1_APN-Q_like	84..545	CDD:341064	143/467 (31%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		0/3 (0%)
		ERAP1_C	618..945	CDD:403137	95/353 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850