DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and Enpep

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	926	Identity:	240/926 - (25%)
Similarity:	411/926 - (44%)	Gaps:	102/926 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||.::.|:.|.:::...:.:  ..:.|.|.|.:...:.|:.:.|:..:..|.|  ...|...:|
Mouse    84 RLPDFINPVHYDLEVKALMEE--DRYTGIVTISVNLSKPTRDLWLHIRETKITK--LPELRRPSG 144

  Fly    90 NSVPVSSIQMDIKLSRLTVSLKRPLKV---NVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQ 151
            ..||:.......|...:.:.....|..   :..|.:.:.|...|.....|||.:.|::.....:
Mouse   145 EQVPIRRCFEYKKQEYVVIQAAEDLAATSGDSVYRLTMEFKGWLNGSLVGFYKTTYMEDGQIRS- 208

  Fly   152 WLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVW--TQF 214
             :|||..||..||::|||||:|..::.:.|::.||..|.||||||.::    :.:.|..|  |.|
Mouse   209 -IAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPKEYSALSNMPEEK----SEMVDDNWKKTTF 268

  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNS 279
            |:|.||.||||.|.:.:|  .......||..|:..:.:|:.....|:|..:...:..::||.|..
Mouse   269 VKSVPMSTYLVCFAVHRF--TAIERKSRSGKPLKVYVQPNQKETAEYAANITQAVFDYFEDYFAM 331

  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344
            .|...|:|.:|:|||...:.|||||..:.|.:||||...|:..:||.||..||..:|:|||||.|
Mouse   332 EYALPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNTV 396

  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESH 409
            ::.||.::||...||.:....||:....:|....:..|:....|.:.|:.:::..|..:|...:.
Mouse   397 TMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQEDDSLMSSHPVVVTVSTPAE 461

  Fly   410 IWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGRLG 474
            |.:.::.|...|.|.:..||...:..|.:....:.||..:....|.:|||||.||        ..
Mouse   462 ITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAKTSDFWDSLQ--------EA 518

  Fly   475 KGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI---------------TPQFRNRWA 524
            ..|.:..:|..|..|.|||:|||:...:     ::|:||.:               |.....|||
Mouse   519 SNLPVKEVMDTWTSQMGYPVVTVSGRQN-----ITQKRFLLDSKADPSQPPSELGYTWNIPVRWA 578

  Fly   525 RNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPF 589
            .|              .:|.|..::|         ..|....|...|..:.  ::..|..|...:
Mouse   579 DN--------------DNSRITVYNR---------LDKGGITLNANLSGDA--FLKINPDHIGFY 618

  Fly   590 RVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFV 654
            ||||:...|..:.:.|:. |..| ....:|:..:||.|:||.:..:.|.:||.:..||:.|::|:
Mouse   619 RVNYEGGTWDWIAEALSS-NHTR-FSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDFL 681

  Fly   655 VW--VATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTH-----RPVI 712
            .|  |.:.:|: .|:........|.:.:||    .:.|.|.|  :||.......:|     |..|
Mouse   682 PWERVISSVSY-IISMFEDDRELYPMIETY----FQGQVKPV--ADLLGWQDTGSHITKLLRASI 739

  Fly   713 IRLACEYELPACVSLARREF---MKGTPEKGGWMTIRERETVVCTAVK-FGTEGDRDMVESMYKR 773
            :..||:......:..|.:.|   :||:..    :.:..|..|....:: .|.|...:.....|::
Mouse   740 LGFACKMGDREALGNASQLFDSWLKGSAS----IPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQK 800

  Fly   774 SNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVN 838
            ::.|.|||.||..||..::|..|.|.|....:.:.::.|:.....:.:..||.|..:|..::.:|
Mouse   801 TSLAQEKEKLLYGLASVKDVKLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKTMAWNWIQLN 865

  Fly   839 MQN-IRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNI 902
            ... :..:..|  |:.:..:..:.|..:|..:|.....||.:......|::...:: ||...:||
Mouse   866 WDYLVSRFTIN--DRYLGRIVTIAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQV-LETVKNNI 927

  Fly   903 HWQRTKFRPMLQAIRD 918
            .|....    .|:||:
Mouse   928 EWLNVN----RQSIRE 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	118/400 (30%)
		M1_APN_2	33..493	CDD:189008	134/464 (29%)
		ERAP1_C	579..897	CDD:288671	76/329 (23%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77
		Peptidase_M1	84..474	CDD:279741	118/401 (29%)
		M1_APN_2	92..537	CDD:189008	134/464 (29%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		0/3 (0%)
		ERAP1_C	608..922	CDD:288671	76/329 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910