DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2111 and erap1

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_002933475.2	Gene:	erap1 / 100496768	XenbaseID:	XB-GENE-983344	Length:	932	Species:	Xenopus tropicalis

Alignment Length:	926	Identity:	248/926 - (26%)
Similarity:	412/926 - (44%)	Gaps:	107/926 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||.:..||.|  |::...|.....|.|...:.:...:.|..:||::..|.|.|   .|:..|.|
Frog    52 RLPTFAAPLHY--DLLIHPNLTTLTFSGLTKVTVTVTQKTSFLVLHSKHLEITK---TTIKRKLG 111

  Fly    90 NSVPVSSIQMDIKL------SRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTT 148
            .    ..:..|:.|      .::.:....||.....|::.:.:.:.|..:..|||.|.|...:..
Frog   112 K----DPVLQDLLLREHPVNEQIALLAADPLIPGENYTIYIEYNANLSKNFRGFYKSTYKTKDGE 172

  Fly   149 LTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHAS--LKDYVW 211
            : :.||:|||||..||.||||||:|.|:..|.|.:.....:.|:|||||.:|:....  |:|:
Frog   173 V-RVLASTQFEPTAARTAFPCFDEPAFKASFSIQIRREPKHHAVSNMPVVKTVNIGGGLLEDH-- 234

  Fly   212 TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDL 276
              |..|..|.||||||::|.|  ...:........||.:|.|:.:.|.|:|......||.||||.
Frog   235 --FAASVKMSTYLVAFIVSDF--KSISQVTNHGVRISVYATPEKIDQAEYALKAAVKLLDFYEDY 295

  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341
            ||.:|...|.||.|:|||...:.|||||..:.|.:||:|.:.|:...:..|...:|..:.:||||
Frog   296 FNISYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLHDPKTSTASHKLWVTMIIAHELAHQWFG 360

  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPD 406
            |||::.||:::||...||.::....|....||...:: :.|......:|.|:..::..|:..|.:
Frog   361 NLVTMEWWNDLWLNEGFAKFMEYVSVRVTYPELQVED-YFLDKCFRAMDVDSLNSSHAVSTPVEN 424

  Fly   407 ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFW----DLLQLQV 467
            ...|...::|:...|.|.:..||...||.|::...:..||..|:.|.|.:.|.|    |:.....
Frog   425 PEEIQEMFDEVSYDKGACILNMLMDYMGAESFEAGIVDYLRRYSYRNARNEDLWNSMTDVCPSDE 489

  Fly   468 DRNGRL-----------GKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRN 521
            ..:|..           |:.:::..:|..|..|.|:||||||....:   :...|..::... .:
Frog   490 TNSGYCTKTRQTSHWSEGEIIDVKSMMNTWTLQKGFPLVTVTVKGKY---VYLHQEHYLKGS-TD 550

  Fly   522 RWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTV----LLEKLE----AEPTDW 578
            ..|....|.:||:|.                       :||||||    |:.|.:    ||..:|
Frog   551 TEASGLLWHIPLTYI-----------------------TSKSNTVQRFLLMSKTDVLVLAEEVEW 592

  Fly   579 ILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGI 643
            |.|||.....:.|:|:...|..|.|.|.:  ....|...:||.|::..|.|...|.:..|.||.:
Frog   593 IKFNVGMNGYYIVHYEGEGWDALIKLLQE--NHTAISSNDRANLINSAFQLVSIGRLPIDKALSL 655

  Fly   644 LGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIF--------KTYMRLLLERQFKRVISSDLT 700
            ..||::||:.:.      .|:.::.:.   |.|.:.        ::.|:..:....:::|.:...
Frog   656 SLYLKNEDKIMP------VFQGMDELI---PIYKLMEKRDMQEVESQMKKYILNLLRKLIDAQSW 711

  Fly   701 SSSGNMTHRPV---IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEG 762
            :..|:::.|.:   ::..||..:...||..| .::.|...|..|.:::.........||...|..
Frog   712 TDEGSVSERMLRSSLLLFACVRQYQPCVQRA-EQYFKRWQESNGTISLPRDVASAVYAVGAQTPE 775

  Fly   763 DRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFE----SSGVRKQNARRTFKAVVS 823
            ..|.:...||.:...:||..:..|||    :.:|:..|.|..|    ...||.|:.......|..
Frog   776 GWDFLFEKYKTTLSGSEKNQIELALA----ITSLKHKLQWLMEEGMKGDHVRTQDLPHIVLYVSR 836

  Fly   824 NSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSE 888
            |.:||.|:.:::..|..|:.......:..|.:::..:.:..||.:.|...:.|| :.|::|....
Frog   837 NPVGYPLSWEFLKNNWGNLVQKFELGSRTVGDMVVGITKQYSTKEWLEEVTGFF-DSLKEMGSQL 900

  Fly   889 RLIKILLERGNDNIHW 904
            |.::...|...:||.|
Frog   901 RCVQQARETIEENIRW 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	127/403 (32%)
		M1_APN_2	33..493	CDD:189008	144/482 (30%)
		ERAP1_C	579..897	CDD:288671	73/332 (22%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	142/477 (30%)
erap1	XP_002933475.2	ERAP1_C	592..911	CDD:378732	75/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020