Protein Alignment CG2111 and erap1

DIOPT Version :10

• Sequence 1: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Sequence 2: XP_002933475.2
• Gene: erap1 / 100496768
• XenbaseID: XB-GENE-983344
• Length: 932
• Species: Xenopus tropicalis
• Alignment Length: 926
• Identity: 248/926 - (26%)
• Similarity: 412/926 - (44%)
• Gaps: 107/926 - (11%)

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||.:..||.|  |::...|.....|.|...:.:...:.|..:||::..|.|.|   .|:..|.|
 Frog    52 RLPTFAAPLHY--DLLIHPNLTTLTFSGLTKVTVTVTQKTSFLVLHSKHLEITK---TTIKRKLG 111

  Fly    90 NSVPVSSIQMDIKL------SRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTT 148
            .    ..:..|:.|      .::.:....||.....|::.:.:.:.|..:..|||.|.|...:..
 Frog   112 K----DPVLQDLLLREHPVNEQIALLAADPLIPGENYTIYIEYNANLSKNFRGFYKSTYKTKDGE 172

  Fly   149 LTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHAS--LKDYVW 211
            : :.||:|||||..||.||||||:|.|:..|.|.:.....:.|:|||||.:|:....  |:|:
 Frog   173 V-RVLASTQFEPTAARTAFPCFDEPAFKASFSIQIRREPKHHAVSNMPVVKTVNIGGGLLEDH-- 234

  Fly   212 TQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDL 276
              |..|..|.||||||::|.|  ...:........||.:|.|:.:.|.|:|......||.||||.
 Frog   235 --FAASVKMSTYLVAFIVSDF--KSISQVTNHGVRISVYATPEKIDQAEYALKAAVKLLDFYEDY 295

  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341
            ||.:|...|.||.|:|||...:.|||||..:.|.:||:|.:.|:...:..|...:|..:.:||||
 Frog   296 FNISYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLHDPKTSTASHKLWVTMIIAHELAHQWFG 360

  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPD 406
            |||::.||:::||...||.::....|....||...:: :.|......:|.|:..::..|:..|.:
 Frog   361 NLVTMEWWNDLWLNEGFAKFMEYVSVRVTYPELQVED-YFLDKCFRAMDVDSLNSSHAVSTPVEN 424

  Fly   407 ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFW----DLLQLQV 467
            ...|...::|:...|.|.:..||...||.|::...:..||..|:.|.|.:.|.|    |:.....
 Frog   425 PEEIQEMFDEVSYDKGACILNMLMDYMGAESFEAGIVDYLRRYSYRNARNEDLWNSMTDVCPSDE 489

  Fly   468 DRNGRL-----------GKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRN 521
            ..:|..           |:.:::..:|..|..|.|:||||||....:   :...|..::... .:
 Frog   490 TNSGYCTKTRQTSHWSEGEIIDVKSMMNTWTLQKGFPLVTVTVKGKY---VYLHQEHYLKGS-TD 550

  Fly   522 RWARNPCWWVPLSYTCPSCQHSEIISFSRWLTCPTSKPSSKSNTV----LLEKLE----AEPTDW 578
            ..|....|.:||:|.                       :||||||    |:.|.:    ||..:|
 Frog   551 TEASGLLWHIPLTYI-----------------------TSKSNTVQRFLLMSKTDVLVLAEEVEW 592

  Fly   579 ILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGI 643
            |.|||.....:.|:|:...|..|.|.|.:  ....|...:||.|::..|.|...|.:..|.||.:
 Frog   593 IKFNVGMNGYYIVHYEGEGWDALIKLLQE--NHTAISSNDRANLINSAFQLVSIGRLPIDKALSL 655

  Fly   644 LGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIF--------KTYMRLLLERQFKRVISSDLT 700
            ..||::||:.:.      .|:.::.:.   |.|.:.        ::.|:..:....:::|.:...
 Frog   656 SLYLKNEDKIMP------VFQGMDELI---PIYKLMEKRDMQEVESQMKKYILNLLRKLIDAQSW 711

  Fly   701 SSSGNMTHRPV---IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEG 762
            :..|:::.|.:   ::..||..:...||..| .::.|...|..|.:::.........||...|..
 Frog   712 TDEGSVSERMLRSSLLLFACVRQYQPCVQRA-EQYFKRWQESNGTISLPRDVASAVYAVGAQTPE 775

  Fly   763 DRDMVESMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFE----SSGVRKQNARRTFKAVVS 823
            ..|.:...||.:...:||..:..|||    :.:|:..|.|..|    ...||.|:.......|..
 Frog   776 GWDFLFEKYKTTLSGSEKNQIELALA----ITSLKHKLQWLMEEGMKGDHVRTQDLPHIVLYVSR 836

  Fly   824 NSMGYRLAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSE 888
            |.:||.|:.:::..|..|:.......:..|.:::..:.:..||.:.|...:.|| :.|::|....
 Frog   837 NPVGYPLSWEFLKNNWGNLVQKFELGSRTVGDMVVGITKQYSTKEWLEEVTGFF-DSLKEMGSQL 900

  Fly   889 RLIKILLERGNDNIHW 904
            |.::...|...:||.|
 Frog   901 RCVQQARETIEENIRW 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	141/476 (30%)
		ERAP1_C	578..897	CDD:463368	74/333 (22%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	142/477 (30%)
		ERAP1_C	592..911	CDD:463368	75/335 (22%)