DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and trhde

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	934	Identity:	268/934 - (28%)
Similarity:	426/934 - (45%)	Gaps:	88/934 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89
            |||..|.||.|.:.:...:|.  ..|.|.|.:::....|::.||::||.|.:  .|.....|:..
Frog   135 RLPTHLRPLHYNLMVTAFMNN--FTFCGEVNVEIECLNSSRYIVVHAHRLTV--ERVQVAEDRVA 195

  Fly    90 NSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLA 154
            ..|.||......:...|.|.|.|.|:...:|::::.:::::.|:..||:.|:||.|....:  ||
Frog   196 GEVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAIIENELLGFFRSSYVLHGERRS--LA 258

  Fly   155 ATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFVESHP 219
            .|||.|.|||:||||||:||::..|||::.|...|.:||||||:.::....  .:|...|.::..
Frog   259 VTQFSPIHARKAFPCFDEPIYKATFKISIRHQTSYLSLSNMPVETSVFEEG--GWVTDHFSQTPL 321

  Fly   220 MQTYLVAFMISKFDRPGFTSSE---RSDCPISTWARPDAL--SQTEFANMVVAPLLSFYEDLFNS 279
            |.||.:|:.:.     .||..|   :|...:..:|||||:  ...::|..:...||.||||.|..
Frog   322 MSTYYLAWAVC-----NFTFKEAVTQSGVVVRLYARPDAIRRGSGDYALNITKRLLEFYEDYFRV 381

  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344
            .|...|:||:|:|...:.:.|||||..|.|:.:|.|...|||.....|...:...:.:||||:||
Frog   382 PYSLPKLDLLAVPKHPYAAMENWGLSVFVEQRILLDPSISSISYLLDVTMVIVHEICHQWFGDLV 446

  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQ------LYLSVLDYDAHVNTDLVTAS 403
            :..||.::|||...|.|....|...|.|.|:.:::..|.      :.|..|.....|:.:::.|:
Frog   447 TPIWWEDVWLKEGLAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLKAT 511

  Fly   404 VPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVD 468
            ..|....|.||     :|.|.|..||...||.:.:...|:.||..:....|..:|.|:.|...:.
Frog   512 DIDRVFDWIAY-----KKGAALIRMLANFMGHKVFQRGLQDYLTTHKYGNAARNDLWNTLTKVLK 571

  Fly   469 RNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI--------TPQFRNRWAR 525
            ..|:|   |||..:|..|..|.|||::|:.||......|...|..|:        ..:|||   :
Frog   572 NEGKL---LNIREVMDQWTLQMGYPVITILRNDTTDDIITITQEHFLYNIDKRTRDKEFRN---K 630

  Fly   526 NPCWWVPLSYTCPSCQH---SEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTA 587
            :..|.:||:....:..|   ..||    |:       |:||....:..|  :.::|:|.|:....
Frog   631 SSLWQIPLTIAVGNTSHISPQAII----WV-------SNKSEYHRIPSL--DESNWVLGNLDQIG 682

  Fly   588 PFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDE 652
            .||||||:|||:||...|.  ....:|...|||.|:||.|:||.:|.:..::.|.|:.||..|.:
Frog   683 YFRVNYDVRNWRLLTDQLM--RNSEVISVSNRAALIDDAFNLARAGYLTQNIPLEIIRYLSEEKD 745

  Fly   653 FVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRV-------ISSDLTSSSGNMTHRP 710
            |:.|.|...:...::.:.....:|.||..|:...:...:.|:       ..|.:.:|......|.
Frog   746 FLPWHAASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWPTNGQNGSAVPTSYQTEELRR 810

  Fly   711 VIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE-------RETVVCTAVKFGTEGDRDMVE 768
            .:|.|||.:....|       ..|.......|::...       |:.|.||.|....|...:.:.
Frog   811 EVIMLACSFGNKQC-------HQKAATMISDWISSNRNRIPPNVRDIVYCTGVSLMDEDVWEFIW 868

  Fly   769 SMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKK 833
            ..:..|...:||:.||.||.||.|...|.|:|..:..|..|..|:|......|..|..|..||.|
Frog   869 MKFHSSTAVSEKKILLEALTCSDNRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWK 933

  Fly   834 YVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKI--LLE 896
            :.....:.:......:......|::.:.|.|:|.:||    ...|:.::...|...:..:  ..|
Frog   934 FFRDKWKILNARYGEALFMNSKLISGVTEFLNTEEEL----NELKDFIQQHKGGSAVASLSRATE 994

  Fly   897 RGNDNIHWQRTKFRPMLQAIRDII 920
            ..:.|:.||......:.|.:|..:
Frog   995 TVDANVRWQHLYRDELFQWLRKTV 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	131/406 (32%)
		M1_APN_2	33..493	CDD:189008	149/470 (32%)
		ERAP1_C	579..897	CDD:288671	85/333 (26%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	147/465 (32%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	87/337 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020