DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2111 and erap2

DIOPT Version :9

Sequence 1:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	993	Identity:	264/993 - (26%)
Similarity:	432/993 - (43%)	Gaps:	149/993 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLSYLTIL---TALFFHLEANKTAVG---------------RLPKWLVPLSYRVDIVTRINQPY 47
            |||.:|.:|   :..:.....:.:..|               |||.::||:.|.  ::...|...
Zfish     2 MHLLFLILLFLESLCYVQSSESNSPTGDNLATDGLPFPWSKVRLPNYIVPVHYH--LLIHPNLTT 64

  Fly    48 QPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDIKLSRLTVS-LK 111
            ..|.|:|.|::..:.:|..:||::.:|.|   ...|:.|::           :..||..|:| |:
Zfish    65 LSFTGSVKIEIDVKNNTNWVVLHSKNLKI---YTATVLDEH-----------EAHLSEKTLSVLE 115

  Fly   112 RPLKVNVT------------YSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAR 164
            .||...:.            |.:.:.|.:.|.:...|||.|.|...:.. |:.||:|.|||..||
Zfish   116 YPLHEQIAIFSPKILTSGEKYFLYLEFGAPLSDGFHGFYKSTYRTKSGE-TRVLASTHFEPTSAR 179

  Fly   165 EAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRT--IRHASLKDYVWTQFVESHPMQTYLVAF 227
            .|.||||:|:|:..:.:.:.....:.||||||:::|  |.:...:|:    |..|..|.:||:||
Zfish   180 MALPCFDEPVFKANYTVRIRRGPSHIALSNMPLEQTVEISNGLFEDH----FEASVKMSSYLLAF 240

  Fly   228 MISKFDR-PGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNSTYRQKKIDLVAL 291
            :|..|.. .|.|:   :...||.:|.|:...||::|......||.|||..||..|...|:||:|:
Zfish   241 IICDFKSVSGLTA---TGINISIYAVPEKWHQTQYALEAALRLLEFYEQYFNILYPLPKLDLIAI 302

  Fly   292 PDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKN 356
            |||...:.|||||..:.|.|||||...||..|:..|...:...:.:|||||||::.||::|||..
Zfish   303 PDFESGAMENWGLTTYRETSLLYDPDISSASDKLWVTMVIGHELAHQWFGNLVTMDWWNDIWLNE 367

  Fly   357 VFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERK 421
            .||.|:....|.::.||...:: |.|......:..|:..::..:::.....:.|...::.:...|
Zfish   368 GFARYMESVSVEAVYPELKVED-HFLDTCFGAIGRDSLNSSRPISSLAESPTQIKEMFDTVSYEK 431

  Fly   422 AAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLL-----------------QLQVDR 469
            .|.:..||...:.:|.:.:.:.|||..::...|.:.|.||.|                 ..|..:
Zfish   432 GACILHMLRHFLTDEGFQSGIIRYLRRFSYCNARNEDLWDSLIKTCSEEDFAAGEYCYSSAQATK 496

  Fly   470 NGR--LGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRF--FITPQFRNRWARNPCW- 529
            |..  .|:.:::.::|..|..|.|.|||||.|  ..|...:.|:||  .:.|.       :|.|
Zfish   497 NAYRFAGEHVDLKKMMNTWTLQKGIPLVTVKR--QGRKLHIGQERFLKIVLPD-------DPSWH 552

  Fly   530 -------W-VPLSYTCPSCQH--SEIISFSRWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQ 584
                   | :||:|......|  ..|:             ..||:.:||:    |..||:..|..
Zfish   553 SLQDGYLWHIPLTYKTSHSDHEVKHIL-------------DKKSDVLLLD----EHVDWVKLNTD 600

  Fly   585 HTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRV----NRAQLVDDLFSLAWSGDIEYDMALGILG 645
            ....:.|:||...|..|.:.|      ::.|..    :||.|:.:.|.|..:|.:..|.||.::.
Zfish   601 MNGYYIVHYDEEGWNALTELL------KVNHTALSFKDRASLIHNAFQLVTAGRLSLDRALDLIA 659

  Fly   646 YLE---HEDEFVVWVATEISFERI---NNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSG 704
            ||:   |....:..:....||.::   ..:|....|   .|||    :.:.||.||.....|..|
Zfish   660 YLKSETHNVPLLQGLGYLQSFYKLIEKRKIADVTHN---LKTY----ILQYFKDVIDKQSWSDDG 717

  Fly   705 NMTHRPV---IIRLACEYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDM 766
            .::.|.:   ::.|||:.:.|.|:..|.|.|:......|   ||.....|..|....|.:.|...
Zfish   718 MVSDRRLREDVLSLACDLDYPPCLEKAERLFVSWVKSNG---TISLPTDVSETVYMVGAQDDSGW 779

  Fly   767 VESM--YKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYR 829
            |..:  |..|....||...|:||..|::...|.|:|....|.:.::.||.......|..|.:|:.
Zfish   780 VYLLRQYGVSMCETEKSKFLSALTSSKDSEKLSRLLQLGMEGTVIKTQNLPSLIYMVARNPVGHF 844

  Fly   830 LAKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKIL 894
            ||..:|..:...:.......:..:..::...:...|:.:||.....|||.| ::.....|:|::.
Zfish   845 LAWDFVKKHWNELVEKFPLGSFGIREIIVGTVTQFSSTEELREVESFFKSI-QEQVSQLRIIQVA 908

  Fly   895 LERGNDNIHWQRTKFRPM 912
            .|....||.|.:.....|
Zfish   909 TENVEKNIVWLKRNLETM 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	128/411 (31%)
		M1_APN_2	33..493	CDD:189008	143/494 (29%)
		ERAP1_C	579..897	CDD:288671	79/332 (24%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	128/412 (31%)
		M1_APN_2	52..522	CDD:189008	143/494 (29%)
		ERAP1_C	595..911	CDD:288671	79/332 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950