DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and LAP2

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_014353.1	Gene:	LAP2 / 855682	SGDID:	S000004990	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	836	Identity:	175/836 - (20%)
Similarity:	276/836 - (33%)	Gaps:	272/836 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATASNLRP---LHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRT----IILSNNGLQVGENV 79
            :|.||.:.   ||.:|:|....|...:||:    |..:|:...|.:.    :.|..:.|.|.| |
Yeast    59 STLSNYKDFAVLHTDLNLSVSFEKSAISGS----VTFQLKKLHEGKNKSDELHLDTSYLDVQE-V 118

  Fly    80 LLVRRNTGGRVTVRKMWQASSVHQLG--IVFNSMLWLGEEYTLVVQFSGQLSRASGYFVGGYMDS 142
            .:.......::..||       ..||  :|.|:.. ..:.:||.:||     |.:        |.
Yeast   119 HIDGSKADFQIEQRK-------EPLGSRLVINNAS-CNDNFTLNIQF-----RTT--------DK 162

  Fly   143 KHHPQWI-----------AVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKT 196
            ....||:           ..:||....|.::||||:..:..:.|..::..|... ..|.:|:..|
Yeast   163 CTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPV-VFSGIRIEDT 226

  Fly   197 SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRP-KIAD-QGDYAISI 259
            |   ||..::...|:.|..     |:.|...:...|: .|.||..|.:..| ::.| |.::...:
Yeast   227 S---KDTNIYRFEQKVPIP-----AYLIGIASGDLSS-APIGPRSTVYTEPFRLKDCQWEFENDV 282

  Fly   260 -----TPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQ 319
                 |.:.|:|       .|.....|.||..|    |:.:.|:.| |...|......:..|:..
Yeast   283 EKFIQTAEKIIF-------EYEWGTYDILVNVD----SYPYGGMES-PNMTFATPTLIAHDRSNI 335

  Fly   320 QVASHVAQEFAHHWLSDL-ENAAL--YWLHNGLSDYVSGFAVDNV--EPAWRFHEL---SMVRQA 376
            .|.:|   |.||.|..:| .|.:.  :||:.|.:.|:....:..:  ||...|..|   |.::.:
Yeast   336 DVIAH---ELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNS 397

  Fly   377 LAVLVEDSKSSAYPMSLAYASKSSD---TQANQKSALLFRMLHSLIGTQA-FLNALRLYLQRSHK 437
            :..:.:..:.|....:|...:...|   |...:|...|...|.:::|.:| |...:|.|.::..|
Yeast   398 IDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAK 462

  Fly   438 GSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLR 502
            .|.....|| .||.|....    :::|..|...::|..:||.|                     .
Yeast   463 KSLDTFQFL-DTLYEFYPE----KKEILDSVDWETWLYKPGMP---------------------P 501

  Fly   503 NPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRL 567
            .|               .|.||..|                        |.....||||    .:
Yeast   502 RP---------------HFITALAD------------------------NVYQLADKWV----EM 523

  Fly   568 ATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFL---GHLR 629
            |...:.|.|.|         |..||..|..|...||:               |.|..|   ||..
Yeast   524 AQHLKTTEDFR---------SEFNAIDIKDFNSNQLV---------------LFLETLTQNGHSN 564

  Fly   630 NEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANITELMVI 694
            .:.:...|                    :.|....|.||....|.:.|     ::||.:...|
Yeast   565 KKPKDFDW--------------------AKFPVASRALLDIYQDNIVK-----SQNAEVVFKM-- 602

  Fly   695 VLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADW--TLLRRLYTRSN 757
                           |..:.||.|..|...:                  |||  |:.|..:.|..
Yeast   603 ---------------FKFQIFAKLQEEYKHL------------------ADWLGTVGRMKFVRPG 634

  Fly   758 V----SEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLG 809
            .    |.:||:.|:         ..||     |...|.|      |..|:.:..||
Yeast   635 YRLLNSVDRRLALA---------TFDK-----FKDTYHP------ICKALVKQDLG 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	51/258 (20%)
		Peptidase_M1	25..392	CDD:279741	90/401 (22%)
		GluZincin	30..480	CDD:301352	111/485 (23%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	173/833 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810