DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and TMA108

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	1006	Identity:	217/1006 - (21%)
Similarity:	368/1006 - (36%)	Gaps:	278/1006 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRT------------------IILSNNGLQV 75
            |.||.|.|  |::|.:.|.||.|..||.|:....:.|                  |:||.:. .:
Yeast    14 PSHYELRL--EIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHA-TI 75

  Fly    76 GENV--LLVRRNTGGRVTVRKMWQASSVHQLGIVFN--SMLWLGEEYTLV--VQFSGQL------ 128
            |...  |.:.::||..::               :||  |.:.|..:..|:  ||:.|::
Yeast    76 GSTKFDLKISQDTGKHLS---------------IFNSESPIQLSNDCPLILSVQYVGKIRDIKTH 125

  Fly   129 -SRASGYFVGGYMDSK-----HHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNA 187
             .:..|.|...:||.|     :|   :..|...|..|:.:|||.:..:..:.|.||:|......|
Yeast   126 HDKTFGIFKTNFMDRKTGTANNH---VVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKA 187

  Fly   188 VSN--MRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIA 250
            |||  :.:::..|..:...|  .|.:||.|:.....|||...               .:|:.:|.
Yeast   188 VSNTPVEMVEALDSSQKHLV--KFAKTPLMTTSVFGFSIGDL---------------EFLKTEIK 235

  Fly   251 DQGDYAISIT-----------------PQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGL 298
            .:||..|.::                 .:.:....|.|..|||..|:|.::||..:..:.|:.|:
Yeast   236 LEGDRTIPVSIYAPWDIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGM 300

  Fly   299 VSY--------PEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSD-----------LENAALYW 344
            ::.        |.|.    |..:.....||:..|   |..|.|:.:           ...:...|
Yeast   301 ITIQLNHLLIPPNAL----ANETVREQAQQLIVH---ELVHQWMGNYISFDSWESLWFNESFATW 358

  Fly   345 L------HNG-LSDYVSG--FAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSL------A 394
            |      .|| ||.|.:.  :.:..|||       :|.|.|..|    :..|.:.::.      :
Yeast   359 LACHILEQNGDLSHYWTSEPYLLQQVEP-------TMCRDAADV----NGRSIFQIAQRNTGIDS 412

  Fly   395 YASKSSDTQANQKSALLFRML-------HSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQE 452
            ..|...|.:|..|..::.|.|       |...|.::.....:.:..||.|...     :|:.:.:
Yeast   413 QTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMD-----IWNHIGK 472

  Fly   453 ESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRV-VRNYD-TNEVTVTQERFLRNPGKLMQKRQQCW 515
            ...:|       .::..:.|||..||.|:::| |...| ..:..:||.||:....  .:::.|..
Yeast   473 FLKSQ-------NITNFVSSWTRTPGLPVVKVEVEEKDGKTQTKLTQHRFINQLS--TEEKDQLE 528

  Fly   516 WVPLTFATAGI--DSFVSTLPSEWLTCQGRQTASP-LILNEVAQPDKWVVFNLRLATPCRITYD- 576
            .||......|:  |..:.| .:..||.:..:...| |::|.:||            ...|::|:
Yeast   529 DVPYQVPLFGVLPDGKMDT-KNVLLTDRTLKFDYPILVINHLAQ------------GYYRVSYES 580

  Fly   577 ERNWQLIGNALSGTNASSIDR----FTRAQLISD-----VLNLAGAGVVTYDLALNFLGHLRNED 632
            |..:.||.:.::....|.||.    ...:|.|.|     .::|.|        ....|.|:.:..
Yeast   581 EECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHG--------LFKILNHIASPS 637

  Fly   633 EFIV---WQAADTYLEWLHRTLRQTTIISTFKGFM-RDLLQTKFDELFKRDGSAAENANITELMV 693
            ..|.   |......||.|....|.:...|..:.|: :.::...|:::....|...::.|..||.|
Yeast   638 TKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKV 702

  Fly   694 IVLQLSCRTDLESCADFALKEFAGLTLETNR--IPVDLSETI------YCTAIQFGTEADWTLLR 750
            :...|....:...||:.....|..| |:..|  :|::|..:|      :|..|:     .|..:.
Yeast   703 MSQVLFLNKNSAKCAELCQIYFKHL-LQGPRSSVPLELVNSILVVVSQHCANIK-----QWKKIF 761

  Fly   751 RLYTRSNV--------------SEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFS 801
            .|..||:.              |.|..:|:       :|.|::.|      |..:..|.|....:
Yeast   762 DLVKRSSCTGITNHVINMYDQNSSETAMLI-------QNGAIESL------GFCLDSDIVKKTLN 813

  Fly   802 AVAQN-----------PLGYNIAKKYLVDNIK--------AIIKLYGSNTDELAQLVTVLMKEVT 847
            .:..|           ...||. ||.|..|.|        .|.:.|..|.|:.|:..|  .|..|
Yeast   814 FITSNIESEGMELALFGFNYNF-KKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKAT--RKGTT 875

  Fly   848 TEEELN-ALR--------MFMRTDLQNLPGF 869
            |.:.|: |||        ||:..:.|.:..|
Yeast   876 TGDHLHKALRSISLIIFQMFVADEPQKIEKF 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	79/373 (21%)
		Peptidase_M1	25..392	CDD:279741	99/445 (22%)
		GluZincin	30..480	CDD:301352	116/545 (21%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	217/1006 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910