DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and Anpep

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_112274.1	Gene:	Anpep / 81641	RGDID:	2991	Length:	965	Species:	Rattus norvegicus

Alignment Length:	942	Identity:	260/942 - (27%)
Similarity:	409/942 - (43%)	Gaps:	112/942 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPIGGTGATASNLRPL--------HYNL-------SLLTEVEPLKLSGN------FSGEVIIRLR 58
            || |.|.||.|...|.        .|.|       |....:.|. |:.|      |.|...:|..
  Rat    50 LP-GSTSATTSTTNPAIDESKPWNQYRLPKTLIPDSYQVTLRPY-LTPNEQGLYIFKGSSTVRFT 112

  Fly    59 VWRETRTIILSNNGLQVGENVLLVRRNTGG-RVTVRKMWQASS-----------VHQLGIVFNSM 111
            ....|..||:.:..|..        .|.|. ||.:|.:....:           ...|.:.....
  Rat   113 CNETTNVIIIHSKKLNY--------TNKGNHRVALRALGDTPAPNIDTTELVERTEYLVVHLQGS 169

  Fly   112 LWLGEEYTLVVQFSGQLS-RASGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPF 175
            |..|.:|.:..:|.|:|: ..:|::...||:. .:.:.:|.||:....|...||||:.....|.|
  Rat   170 LVKGHQYEMDSEFQGELADDLAGFYRSEYMEG-GNKKVVATTQMQAADARKSFPCFDEPAMKASF 233

  Fly   176 ILNLAHPRGTNAVSNMRVLKTSDHEKDDYVW--TTFQQTPAMSVQKLAFSINRFTNRTSAEIPKG 238
            .:.|.||....|:||| :.|.|...::|..|  |.|..||.||...||:.::.| ....|..|..
  Rat   234 NITLIHPNNLTALSNM-LPKDSRTLQEDPSWNVTEFHPTPKMSTYLLAYIVSEF-KYVEAVSPNR 296

  Fly   239 PALTTWLRPKIADQ--GDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSY 301
            ..:..|.||...|:  ||||:.:|..|:.||...:...||..|.||:.|||....:.|:.|||:|
  Rat   297 VQIRIWARPSAIDEGHGDYALQVTGPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTY 361

  Fly   302 PEAAFLYSAQRSTTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEP 363
            .|:|.::..|.|:...|::|.:.:|.|.||.|..:|.....:   ||:.|.:.||.....|..||
  Rat   362 RESALVFDPQSSSISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEP 426

  Fly   364 AWRFHELSMVRQALAVLVEDSKSSAYPMSL--------AYASKSSDTQANQKSALLFRMLHSLIG 420
            .|...:|.::.....|:..|:.:|::|:|.        |..|:..|:....|.|.:.|||.|.:.
  Rat   427 TWNLKDLIVLNDVYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLT 491

  Fly   421 TQAFLNALRLYLQRSHKGSSSNQAF--LWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIR 483
            ...|...|..||   |....||..:  ||..||:..|:|.:::....||.:||.|.:|.|:|:|.
  Rat   492 EDLFKKGLSSYL---HTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVIT 553

  Fly   484 VVRNYDTNEVTVTQERFLRNPGKLMQKRQQ---CWWVPLTFATAGIDSFVSTLPSEWLTCQGRQT 545
            |  |..|.|  :.||.||.:|.....:...   .|.||:.:...|.:...      ||..:..|:
  Rat   554 V--NTSTGE--IYQEHFLLDPTSKPTRPSDFNYLWIVPIPYLKNGKEDHY------WLETEKNQS 608

  Fly   546 ASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNL 610
            |     ......::|::.|:.:....::.|||.||:.|.|.|. |:.|.|....|||:|.|..||
  Rat   609 A-----EFQTSSNEWLLLNINVTGYYQVNYDENNWRKIQNQLQ-TDLSVIPVINRAQIIHDSFNL 667

  Fly   611 AGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRD-------LL 668
            |.||.::..|.|:....|.:|.|::.|:||.:.|.:......::.:....|.:::.       ..
  Rat   668 ASAGKLSITLPLSNTLFLASETEYMPWEAALSSLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYF 732

  Fly   669 QTKFDELFKRDGSAAENANITELMVIVLQLSCRTDLESCADFALKEFAGL------TLETNRIPV 727
            :.|.:....|..:..|..|    .:..:..:|.:.||.|.|..:    ||      ..:.|.|..
  Rat   733 KIKTNNWLDRPPTLMEQYN----EINAISTACSSGLEECRDLVV----GLYSQWMNNSDNNPIHP 789

  Fly   728 DLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMP 792
            :|..|:||.||.||.|.:|......:.::.:..|...|.||:|||.|.|.|::.|:......|:.
  Rat   790 NLRSTVYCNAIAFGGEEEWNFAWEQFRKATLVNEADKLRSALACSNEVWILNRYLSYTLNPDYIR 854

  Fly   793 KDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRM 857
            |.|......::|.|.:|..:...::..|.|.:.:.||..:...|.|:..:.:..::|.||..|..
  Rat   855 KQDATSTIVSIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVTRRFSSEFELQQLEQ 919

  Fly   858 FMRTDLQNLPGF---EIAFRRILELGEDNISW 886
            |...:  :..||   ..|..:.||..:.||.|
  Rat   920 FKEDN--SATGFGSGTRALEQALEKTKANIKW 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	86/332 (26%)
		Peptidase_M1	25..392	CDD:279741	113/407 (28%)
		GluZincin	30..480	CDD:301352	141/500 (28%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68		8/18 (44%)
		Metalloprotease	69..965		252/922 (27%)
		Peptidase_M1	75..479	CDD:279741	114/415 (27%)
		M1_APN_2	84..550	CDD:189008	139/480 (29%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		0/3 (0%)
		ERAP1_C	619..942	CDD:288671	87/333 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940