DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and npepps

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	924	Identity:	210/924 - (22%)
Similarity:	379/924 - (41%)	Gaps:	122/924 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGR 89
            :::||::|.|.|    :|..:...|.|::...:.|...|..|:::...:.:
Frog    12 TDVRPVNYGLCL----KPDLIDFTFEGKLEATVEVQNATNQIVMNCADIDI-------------- 58

  Fly    90 VTVRKMWQA-SSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSRASGY----FVG-------GYMDS 142
            :|.....:. ..:|..|  ||   :..|:..:.:.|...|.:.:|.    |||       |:..|
Frog    59 ITASYAPEGDEEIHATG--FN---YQNEDEKVTLSFPSTLQKGAGMLKIDFVGELNDKMKGFYRS 118

  Fly   143 KH-----HPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDHEKD 202
            |:     ..::.||||.....|...|||::.....|.|.:.|..|:...|:|||.::....:..|
Frog   119 KYATATGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDVILIVPKDRVALSNMNLIDRKPYPDD 183

  Fly   203 D-YVWTTFQQTPAMSVQKLAFSINR--FTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQII 264
            : .|...|.:||.||...:||.:..  |....|::   |..:..:.....|:||.:|:.:..:.:
Frog   184 ENLVEVKFARTPIMSTYLVAFVVGEYDFVETRSSD---GVLVRVYTPVGKAEQGKFALEVAAKTL 245

  Fly   265 VFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEF 329
            .|:...|..|||..|||.:.:.|.|..:.|:.|||:|.|.|.|...:.|.:.::|.||..|..|.
Frog   246 PFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHEL 310

  Fly   330 AHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAW----RFHELSMVR-QALAVLVEDSKS 386
            ||.|..:|.....:   ||:.|.:.::....||:..|.:    :|......| |.|     |:..
Frog   311 AHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQEL-----DALE 370

  Fly   387 SAYPMSLAYASKSS-----DTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFL 446
            :::|:.::....|.     |..:..|.|.:.||||..||.:.|...:..||.:..:.:::.:. |
Frog   371 NSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATED-L 434

  Fly   447 WHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKR 511
            |.:|::.|..        .::.:|::||.|.|:|||.|......:.|.:          ||.||:
Frog   435 WESLEQASGK--------PIAAVMNTWTKQMGFPLICVESEQKEDSVVL----------KLSQKK 481

  Fly   512 QQCWWVPLTFATAGI----DSFVSTLPSEWLTCQGRQTASPLILN---------EVAQPDKWVVF 563
                     |..:|.    ||:...:|....|.:...:|:..||.         |..:|.:||..
Frog   482 ---------FCASGAPNSDDSYQWMVPISICTSESPASATVKILMDKPEMTVVLEGVKPHQWVKL 537

  Fly   564 NLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHL 628
            |.......|..|   :..::.:.|.|....|:....|..|.:|:.:||.||::.....|..:...
Frog   538 NPGTVGFYRTQY---STTMLESLLPGIRDLSLQPVDRLGLQNDLFSLARAGMINTAEVLKVMEAF 599

  Fly   629 RNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKR---DGSAAENANITE 690
            .||..:.||......|..|...|..|......:.|:||:    |..:.:|   |....|......
Frog   600 VNEPNYTVWSDLSCNLGILSTLLSHTDFHEEIQCFVRDV----FSPIGQRLGWDPKPGEGHLDAL 660

  Fly   691 LMVIVLQLSCRTDLESCADFALKEFAGLTLETNRIPVDLSETIYCTAIQFGTEADWTLLRRLYTR 755
            |..:||....:...:...:.|.:.|.......|.:..||...:|.|.::.|..:....:.:|:.:
Frog   661 LRGLVLGKLGKAGHQPTLEEARRRFKEHVDGRNVLSADLRSPVYVTVLKHGDNSTLETMMKLHKQ 725

  Fly   756 SNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDN 820
            :::.||:..:...:....|...:.|:|:.:.:....|:|.|.:|......:.||...|..::.||
Frog   726 ADMQEEKNRIERVLGAIAEQDLIKKVLSFSLSEDVRPQDTVCVIGGVAGGSKLGRKCAWNFVKDN 790

  Fly   821 IKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQNLPGFEIAFRRILELGEDNIS 885
            .:.:...|.... .:::|:.:.:....:::....::.|.  |....|..|...::..|....|..
Frog   791 WEELYNRYQGGF-LISRLIKLSLDGFASDKMAAEIKAFF--DAHPAPSAERTVQQCCENILLNAG 852

  Fly   886 WHNRQ----YHNLL 895
            |..|.    :|.||
Frog   853 WLKRDAEAIHHYLL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	62/319 (19%)
		Peptidase_M1	25..392	CDD:279741	98/394 (25%)
		GluZincin	30..480	CDD:301352	118/482 (24%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	100/415 (24%)
		M1_APN_2	17..460	CDD:189008	118/482 (24%)
		ERAP1_C	535..846	CDD:288671	62/320 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010