DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9806 and Lvrn

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	907	Identity:	245/907 - (27%)
Similarity:	393/907 - (43%)	Gaps:	87/907 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PWYLIVLHLCLPIGGTGATASNLRPLHYNLSLLTEVEPLKLSG---NFSGEVIIRLRVWRETRTI 66
            ||.    ||.||        ..|.||||:|.|...::|.|||.   .|:|.|.|.:|....:..:
Mouse    89 PWD----HLRLP--------PWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRL 141

  Fly    67 ILSN---NGLQV---GENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFS 125
            :|.:   |..||   |......|..|.|||.|.|:|.|..:..:.:.....|..|..|.|...||
Mouse   142 LLHSFLLNYKQVEVWGPLAQDTRNATVGRVQVEKVWFAPDMQFVVLDLGQSLEPGSRYELSFHFS 206

  Fly   126 GQLSRA--SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAV 188
            ||:.:.  .|.|:..|.|.......:| ||:.|..|..|||||:.....|.|.:.:.|..|..|:
Mouse   207 GQVLQVGLEGLFLNLYHDEDELRALVA-TQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAAL 270

  Fly   189 SNMRVLKTSDH-EKDDYVW--TTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIA 250
            |||..|..|:. :.:...|  |||..||.|....:|..:....:.:..|  :|..:..|.|....
Mouse   271 SNMPQLGQSERIDVNGSRWTVTTFHTTPRMPTYLVALVVCDLDHISRTE--RGKEIRVWARKDDI 333

  Fly   251 DQG--DYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRS 313
            ..|  |:|.:||..|..|...||...|...|.|.:.||..|..:.|:.||:.:.|::.|...:..
Mouse   334 ASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDE 398

  Fly   314 TTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQ 375
            .|..:..:.|.:|.|..|.|..:|...:.:   ||:.|.:.|......:...|....:.:.....
Mouse   399 LTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTV 463

  Fly   376 ALAVLVEDSKSSAYPMSLAYASKSSDTQAN--------QKSALLFRMLHSLIGTQAFLNALRLYL 432
            ...:|.||....:..:|.|..:.:..::.|        :|.|.:..||.|.:....|:|||:.||
Mouse   464 LHGILGEDHALESRAVSTAVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYL 528

  Fly   433 QRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQ 497
            : :...|::.|..||..:|.....|........|..:|||||.:.|:|:|.|  |..|.  .|.|
Mouse   529 E-TFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV--NVSTG--VVKQ 588

  Fly   498 ERFL--RNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDK- 559
            |.|.  :...:.:......|.||:.:...||..     |..||      ..|.::...:...|.
Mouse   589 EPFYLDKVENQTLLSHNSTWIVPIFWMKNGIPQ-----PLVWL------DKSNMMFPGMKLSDSD 642

  Fly   560 --WVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLAL 622
              ||:.|..:....|:.|||..|:.:...|. .:..:|....|.||:||...|.....:..:.||
Mouse   643 SDWVILNFNVTGYYRVNYDELGWKKLSEQLE-KDPKAIPVINRLQLVSDAFALTKNNYIEIETAL 706

  Fly   623 NFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFK------RDGS 681
            :...::..|||.:||  .:..|..::|.:............::..|..:|:.::.      |:..
Mouse   707 DLTKYIAEEDEILVW--FEVLLNLINREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAIIRENV 769

  Fly   682 AAENANITELMVI--VLQLSCRTDLESCADFALKEFAGLTL--ETNRIPVDLSETIYCTAIQFGT 742
            |:...|...|..:  :.:.:|...||.|...:.:.|...|.  || .||..:...:.|:|:..|:
Mouse   770 ASLQDNYLSLFSLERIFETACWLGLEDCLQLSRELFKKWTAHPET-AIPPQIENAVLCSAVALGS 833

  Fly   743 EADWTLLRRLYTRSNVSEE---RRILLSAMACSRENWALDKLLNLAF--AGRYMPKDDVLLIFSA 802
            :.||..|..||..:...|:   ||.|:.||:||::.|.|::.:..|.  ......:.:::::
Mouse   834 DKDWDFLFNLYINTTEEEDESRRRRLVHAMSCSKDPWILNRFMEYAITAVSSNFSETNIIVV--- 895

  Fly   803 VAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRMFMRTDLQ 864
            ||.:.:|..|||.:|:||..|:.:.||  .|.|..||.||.:.|:|::::..|:.|..|.|:
Mouse   896 VATSEVGRYIAKDFLMDNWVAVTERYG--MDWLDALVPVLGRTVSTDQQVTELQHFFSTVLE 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	83/319 (26%)
		Peptidase_M1	25..392	CDD:279741	109/385 (28%)
		GluZincin	30..480	CDD:301352	134/476 (28%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	114/420 (27%)
		M1_APN_2	102..575	CDD:189008	134/476 (28%)
		Substrate binding. /evidence=ECO:0000250	376..380		0/3 (0%)
		ERAP1_C	646..964	CDD:288671	83/319 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840