DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9806 and erap1a

DIOPT Version :9

Sequence 1:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	942	Identity:	231/942 - (24%)
Similarity:	405/942 - (42%)	Gaps:	91/942 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YLIVLHLCLPIGGTGATASN------------------LRPLHYNLSLLTEVEPLKLSGNFSGEV 53
            :.:|...|....|..|...|                  ::|.||:|.    :.|...|..|:|||
Zfish    10 FTLVALFCALFAGNHAMTVNKNKTVLPFPWDKMRLPEIVKPQHYDLL----IHPNLTSLTFTGEV 70

  Fly    54 IIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEY 118
            .|::.|.::||.|||.:..|||.:.:||..|.......: ::.:..:..|:.:......:....:
Zfish    71 QIQIEVKQDTRAIILHSKNLQVSKALLLGSRQHHHHQDL-QISEFEANEQIALFSEGFTFEKGSH 134

  Fly   119 TLVVQFSGQLSRA-SGYFVGGYMDSKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHP 182
            .:.::|...||.: .|::.|.|..:....:.:|.||..|..|...||||:...|.|.|.:.:...
Zfish   135 VVHLEFYANLSDSFHGFYKGQYTTNSGEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRE 199

  Fly   183 RGTNAVSNMRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRP 247
            ....::|||..|:|.: ..|..:...|.....||...:||.|..| :..|.:...|..::.:..|
Zfish   200 SRHISISNMPKLRTVE-LADGILEDQFDTMVKMSTYLVAFIICDF-HSISKKSQHGVEISVYTVP 262

  Fly   248 KIADQGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQR 312
            :...|.:||:.....::.|:...|..|||..|.|...:||....:.|:.||.:|.|:..|:..::
Zfish   263 EKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTYRESGLLFDPEK 327

  Fly   313 STTRAKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAWRFHELSMVR 374
            |::..|..:...:|.|.||.|..:|.....:   ||:.|.:.::...:|:...|..:.::. .:.
Zfish   328 SSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPELQVNDY-FLE 391

  Fly   375 QALAVLVEDSKSSAYPMSL-----AYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQR 434
            :....|..||.||::|:|.     |..|:..|..:.:|.|.:..||...:..:.|...:..||::
Zfish   392 KCFTALSVDSLSSSHPVSTPVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKK 456

  Fly   435 SHKGSSSNQAFLWHTLQE--ESDNQMSLR----------------------QDIKVSQLMDSWTM 475
             |...::..:.||.:|..  .||...|.|                      ..:.|..:||:||:
Zfish   457 -HSYQNTVNSHLWESLTNICTSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTL 520

  Fly   476 QPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTC 540
            |.|:|||.|  .....|||:.|||||:. .:........|.||||:.|:|     |.....:|..
Zfish   521 QEGFPLITV--EVKGQEVTLKQERFLKG-AESSNSSSFLWQVPLTYITSG-----SNAVQRFLLK 577

  Fly   541 QGRQTASPLILNEVAQPDK--WVVFNLRLATPCRITYDERNWQLIGNAL--SGTNASSIDRFTRA 601
            ..|..        ...|:|  |:.||:.|.....:.|:...|..:...|  :.|..||.|   ||
Zfish   578 TERDV--------FYLPEKVEWIKFNVDLRGYYIVHYESGGWDCLIKQLRMNHTVFSSND---RA 631

  Fly   602 QLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRD 666
            .||.|:..|.....|..|.|||...:|..|.|.:......:.|..|:: |.:...:...:..::.
Zfish   632 SLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVTQGFSELVPLYK-LMEKRDMQELENQLKS 695

  Fly   667 LLQTKFDELFKRDGSAAENANITELMV--IVLQLSCRTDLESCADFALKEFAGLTLETNR--IPV 727
            .|...|..|..|. |.::|.:::|.|:  .:|..:|.....||...|.:.|........:  :|.
Zfish   696 HLVKLFQPLIDRQ-SWSDNGSVSERMLRNYLLLFACVRRYPSCVSTATQLFHKWKESDGKMWLPT 759

  Fly   728 DLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMP 792
            |:|..:|....:  |:..|..|...|.||....|:.::.:|::.|.....|..||..:..|..|.
Zfish   760 DVSLVVYTEGAR--TDDGWDFLLEKYKRSVSPSEKWMIKAALSYSPLAHKLQWLLERSSEGEIMK 822

  Fly   793 KDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEELNALRM 857
            ..|:..:..:|::||.|:.:|..:|..|...::|.:...:..::::|..:..:.:|:|.|:.:.:
Zfish   823 TQDLPSMLISVSKNPKGFKLAWDFLKSNWGKLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVEL 887

  Fly   858 FMRTDLQNLPGFEIAFRRILELGEDNISWHNR 889
            |..:..|:......:.::.||..:.||.|.:|
Zfish   888 FFGSLAQDQGSGLRSIQQALEKIQQNILWMDR 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	74/322 (23%)
		Peptidase_M1	25..392	CDD:279741	96/388 (25%)
		GluZincin	30..480	CDD:301352	120/482 (25%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	99/394 (25%)
		M1_APN_2	52..525	CDD:189008	120/481 (25%)
		ERAP1_C	592..909	CDD:288671	75/323 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850